[PDF] Top 20 MicroRNA-mediated drug resistance in breast cancer

... with resistance to DNA-damaging agents (Chen et ...of breast cancer cases, sensitized drug-resistant cell populations to stress-induced apoptosis (Neal et ...paclitaxel resistance (Zhou ... See full document

... As mention above, each of the substrate conditions in this study prompt us to examine the proliferation and drug responsiveness of both breast cancer cells cultured on different substrates with ... See full document

... colorectal cancer progression, improve quality of life, and prolong survival ...reverse drug-resistance cancer [12,13] and sup- press the nuclear translocation of p50/p65 NF-κB proteins and ... See full document

... AKT/mTOR and MAPK signaling pathways and their cross- talk and feedback loops in gemcitabine resistance in breast cancer cells is still unknown. To receive highly effective clini- cal benefit, dual ... See full document

... promoting drug resistance; therefore, the observation that ETV7 can be differently activated by cytotoxic drugs used in chemotherapy (based on their mechanism of action) with respect to the patient- and ... See full document

... human breast cancer (in particular, miR-10b, miR-17-5p, miR-21, miR-27a, miR-27b, miR-125a, miR-125b, miR-126, miR-145, miR-155, miR- 200c, miR-206, miR-336 and the let-7 family) ...chemotherapy ... See full document

... aberrant microRNA expression is strongly implicated in the development of drug ...be drug transporters, drug targets or cell apoptosis and cell-cycle- related components, resulting in ... See full document

... Expression data was median centered such that tumor expression profiles reflected the expression of a given miRNA relative to the average expression of the miRNA across all tumors. The value of the cyclin ... See full document

... multi-drug resistance 1 (MDR1) in human and is expressed widely in epithelial cells of many organs ...of breast cancer, paclitaxel (PTX, a microtubule-stabilizing drug) and doxorubicin ... See full document

... to resistance to cellular ionizing radiation ...suppressed cancer cell ...was mediated in part by miR-125b- mediated down-regulation of proto-oncogene ERBB2 ... See full document

... of cancer glucose ...three breast cancer cells, BT474, SKBR3 and MCF7 ...human breast can- cer patient samples compared with their adjacent normal tissues ... See full document

... women, breast carcinoma is the leading cause of cancer death ...females, breast cancer has ranked number one cancer with mortality ...national cancer registries were compared for ... See full document

... Breast cancer (BC) is the second most commonly diagnosed malignant cancer and the fi fth most common cause of cancer-related death ...total cancer deaths) ...of resistance to ... See full document

... Multi-drug resistance to chemotherapeutic agents is a major cause of treatment failure in breast cancer, because chemotherapy plays ever increasing role in the systemic treatment modalities of ... See full document

... Breast cancer-associated macrophages express high levels of insulin-like growth factors 1 and 2 (IGFs) and are the main source of IGFs within both primary and metastatic tumors ...of breast ... See full document

... and cancer cells plays an important role in transfer of drug resistance through exosomal ...damage resistance signature includ- ing STAT1, MX1, ISG15, OAS1, IFIT1, IFIT3, and IFI44, which has ... See full document

... the drug into the vesicles or into the PLC. Once inside the drug would be trapped until the vesicles fused with the plasma membrane and effluxed out of the ...on drug-trapping in the acidic endosomal ... See full document

... with resistance to chemotherapy in lung cancer recently ...of cancer metastases. Drug resistance has been correlated with the presence of the molecular “pump” in tumor cell membranes ... See full document

... Fig 2 ABCG2/BCRP is up-regulated by tamoxifen in ER-positive breast cancer cells. (A-C) T47D cells were treated with 1µM or 5µM tamoxifen or vehicle control (100% ethanol) for the indicated lengths of time ... See full document

... liver cancer by downregulating EZH2 and increased the sensitivity of drugs that inhibited cell ...in breast cancer was rare, and its expression regulation and speci fi c mechanism of action were still ... See full document