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[PDF] Top 20 The microRNA miR 29a is associated with human immunodeficiency virus latency

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The microRNA miR 29a is associated with human immunodeficiency virus latency

The microRNA miR 29a is associated with human immunodeficiency virus latency

... J1.1 latency models we observed miR-29a levels to reduce following PMA activation and HIV-1 replication, and this correlated with expression of the Nef ...of miR-29a in the PBMCs and ... See full document

5

Herpes Simplex Virus 2 MicroRNA miR-H6 Is a Novel Latency-Associated Transcript-Associated MicroRNA, but Reduction of Its Expression Does Not Influence the Establishment of Viral Latency or the Recurrence Phenotype

Herpes Simplex Virus 2 MicroRNA miR-H6 Is a Novel Latency-Associated Transcript-Associated MicroRNA, but Reduction of Its Expression Does Not Influence the Establishment of Viral Latency or the Recurrence Phenotype

... HSV-2 miR-H6 contributes elements essential for viral species-specific reactivation of HSV-2, the viruses were evaluated in the guinea pig genital ...mutant virus, NotPolyA, expresses a significant lower ... See full document

9

Feline immunodeficiency virus latency

Feline immunodeficiency virus latency

... viral latency is established and maintained, and perhaps even more im- portantly, how it can be manipulated, is of great import- ance to viral eradication ...viral latency (so-called anti-latency ... See full document

8

HUMAN IMMUNODEFICIENCY VIRUS ASSOCIATED TUBERCULOSIS

HUMAN IMMUNODEFICIENCY VIRUS ASSOCIATED TUBERCULOSIS

... ≥75% of TB patients had documented HIV test in which 23 achieved levels of ≥90% (Fig.1). [8] The 2016 United Nations Political Declaration on Ending AIDS, targeted to reduce TB- related deaths among people living with ... See full document

17

Determinants of the Establishment of Human Immunodeficiency Virus Type 1 Latency

Determinants of the Establishment of Human Immunodeficiency Virus Type 1 Latency

... been associated with HIV-1 latency (23, 60, 61), and HDAC inhibitors have been reported to reactivate latent HIV-1 infec- tion (49, 52, ...that latency establish- ment would be regulated by HDAC ... See full document

16

Human cellular microRNA hsa miR 29a interferes with viral nef protein expression and HIV 1 replication

Human cellular microRNA hsa miR 29a interferes with viral nef protein expression and HIV 1 replication

... miRNAs are nodal molecules in an intricate network of host-virus interactions that form a chain of strategies and counter strategies developed by the virus and the host[26]. Taken together, the range of ... See full document

10

Latency in Human Immunodeficiency Virus Type 1 Infection: No Easy Answers

Latency in Human Immunodeficiency Virus Type 1 Infection: No Easy Answers

... the virus is persisting as genetic information in a stably integrated form in rare memory cells that cannot be distinguished from their uninfected ...the virus, with its attendant damage to the im- mune ... See full document

7

Effects of Prostratin on T-Cell Activation and Human Immunodeficiency Virus Latency

Effects of Prostratin on T-Cell Activation and Human Immunodeficiency Virus Latency

... context of HAART may allow clearance of the infected cell either by immune-mediated mechanisms or by direct viral cy- topathic effects while at the same time preventing de novo infection of additional T cells. Because ... See full document

6

Human Immunodeficiency Virus (HIV) Latency: The Major Hurdle in HIV Eradication

Human Immunodeficiency Virus (HIV) Latency: The Major Hurdle in HIV Eradication

... the human immunodeficiency virus (HIV), even in patients who sup- press the virus to undetectable levels for many years, underscores the problems associated with fighting this ...HIV ... See full document

13

MicroRNA miR-155 Is Necessary for Efficient Gammaherpesvirus Reactivation from Latency, but Not for Establishment of Latency

MicroRNA miR-155 Is Necessary for Efficient Gammaherpesvirus Reactivation from Latency, but Not for Establishment of Latency

... maintaining latency. However, it has been shown that the different stages of latency seen in EBV infection are associated with differing levels of miR-155 ...nine ... See full document

11

Estimating Initial Viral Levels during Simian Immunodeficiency Virus/Human Immunodeficiency Virus Reactivation from Latency

Estimating Initial Viral Levels during Simian Immunodeficiency Virus/Human Immunodeficiency Virus Reactivation from Latency

... of virus produced by a reactivating latent cell may affect the ease with which it may be neutralized by ...of virus and the random timing of reactivation ... See full document

10

MicroRNA miR-BART20-5p Stabilizes Epstein-Barr Virus Latency by Directly Targeting BZLF1 and BRLF1

MicroRNA miR-BART20-5p Stabilizes Epstein-Barr Virus Latency by Directly Targeting BZLF1 and BRLF1

... maintain latency using various mechanisms and establish lifelong infection in the ...by miR- BART20-5p to suppress the lytic cycle and progeny virus ...in latency maintenance in ... See full document

11

Molecular Characterization of Preintegration Latency in Human Immunodeficiency Virus Type 1 Infection

Molecular Characterization of Preintegration Latency in Human Immunodeficiency Virus Type 1 Infection

... preintegration latency (1, 12, ...the virus in the pre- integration state and the kinetics of reverse transcription in resting CD4 ⫹ T cells, we infected purified resting CD4 ⫹ T cells with a recombinant ... See full document

14

Human immunodeficiency virus-associated vasculopathy in transgenic mice.

Human immunodeficiency virus-associated vasculopathy in transgenic mice.

... There is substantial clinical evidence for the development of vascular disorders in human immunodeficiency virus (HIV)-infected individuals, particularly in the form of vasculitis. Transgenic mice ... See full document

6

Latency and reactivation of JC virus in peripheral blood of human immunodeficiency virus type 1 infected patients

Latency and reactivation of JC virus in peripheral blood of human immunodeficiency virus type 1 infected patients

... In our HIV-1-infected patients, whether or not they were affected by PML, JCV DNA was frequently present in periph- eral blood. It was also found in healthy blood donors, although significantly less frequently. Moreover, ... See full document

5

Intestinal Epithelial Barrier Disruption through Altered Mucosal MicroRNA Expression in Human Immunodeficiency Virus and Simian Immunodeficiency Virus Infections

Intestinal Epithelial Barrier Disruption through Altered Mucosal MicroRNA Expression in Human Immunodeficiency Virus and Simian Immunodeficiency Virus Infections

... during human immunodeficiency virus (HIV) infection has largely been attributed to the rapid and severe depletion of CD4 ⴙ T cells in the gastrointestinal (GI) ...specifically microRNA ... See full document

14

Latency-Associated Nuclear Antigen Encoded by Kaposi's Sarcoma-Associated Herpesvirus Interacts with Tat and Activates the Long Terminal Repeat of Human Immunodeficiency Virus Type 1 in Human Cells

Latency-Associated Nuclear Antigen Encoded by Kaposi's Sarcoma-Associated Herpesvirus Interacts with Tat and Activates the Long Terminal Repeat of Human Immunodeficiency Virus Type 1 in Human Cells

... GST-Tat was incubated with the amino-terminal and central domains of LANA. LANA induces expression of the HIV-1 p24 gag gene product when cotransfected with an infectious HIV-1 clone in 293T cells. Based on the results ... See full document

11

Extracellular Vpr protein increases cellular permissiveness to human immunodeficiency virus replication and reactivates virus from latency.

Extracellular Vpr protein increases cellular permissiveness to human immunodeficiency virus replication and reactivates virus from latency.

... of human immunodeficiency virus (HIV) and simian immunodeficiency virus is a virion-associated regulatory protein that has been shown using vpr mutant viruses to increase ... See full document

12

Proteasome inhibitors act as bifunctional antagonists of human immunodeficiency virus type 1 latency and replication

Proteasome inhibitors act as bifunctional antagonists of human immunodeficiency virus type 1 latency and replication

... accordance with our preliminary results, led us to formu- late the hypothesis that the proteasome is involved in maintaining HIV-1 latency. Indeed, as shown in Figures 1, 2, and 3, inhibiting the proteasome ... See full document

15

Efficiency of Cell-Free and Cell-Associated Virus in Mucosal Transmission of Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus

Efficiency of Cell-Free and Cell-Associated Virus in Mucosal Transmission of Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus

... cell-associated virus, PBMCs from an SIV-naive do- nor monkey were isolated by Ficoll gradient centrifugation, washed re- peatedly, and then exposed to a low dose (MOI ⬍ ...free virus and infected ... See full document

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