[PDF] Top 20 MITOCHONDRIA: INSIGHT TARGET OF DRUG DEVELOPMENT IN CANCER CELLS
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MITOCHONDRIA: INSIGHT TARGET OF DRUG DEVELOPMENT IN CANCER CELLS
... the development of novel and specific therapeutic agents targeted to the mitochondria 7 ...the mitochondria under certain pathological conditions such as traumatic brain injury and ...second ... See full document
9
New HSP27 inhibitors efficiently suppress drug resistance development in cancer cells
... as cancer target, there are – to the best of our knowledge – currently only two cancer therapy approaches targeting HSP27 under clinical ...tumor cells in castration resistant prostate ... See full document
14
<p>Targeting stem cells in the realm of drug-resistant breast cancer</p>
... breast cancer (BC) has been a conundrum that ails millions of women every ...This cancer has been well studied by researchers all over the world, which has improved the patient outcome ...this cancer ... See full document
21
Isolate and identified cancer stem cells by using MCF7 human breast cancer cell line, using mammospheres formation in two different methods
... new cells (Razmkayshi et ...tumour cells had been impervious to illumination treatment and chemotherapy medications, for example, It is an anthracycline drug that acts by intercalating DNA strands, ... See full document
30
Changes in DNA methylation are associated with the development of drug resistance in cervical cancer cells
... therapeutic target [50, ...cause drug resist- ance, then detection of this modification might be used to monitor the development of drug ...of drug resistance, then it could be a ... See full document
9
Distinct effects of TRAIL on the mitochondrial network in human cancer cells and normal cells: role of plasma membrane depolarization
... anticancer drug due to its tumor-selective ...malignant cells and normal ...human cancer cell lines and normal cells exhibited two different modes of mitochondrial responses in response to ... See full document
17
The Mechanisms of Mitochondria-Mediated Apoptosis in Cancer Chemotherapy
... embryonic development as well as maintains tissue ...dying cells and on the DNA fragmentation or damages, two distinct patterns of cell death have been ...of cells during PCD occurs with apoptotic ... See full document
5
Lowering the apoptotic threshold in colorectal cancer cells by targeting mitochondria
... Doxycycline, one of the most widely used TCNs in clinical practice, is a long acting orally administered che- mical agent. Apart from its antibiotic properties, it has been shown to inhibit cell proliferation and ... See full document
8
Hedgehog pathway as a drug target: Smoothened inhibitors in development
... therapeutic target in various human ...embryonic development, but is typically silenced in adult tissues, with reactivation usually only during tissue ...self-renewing cells (cancer stem ... See full document
12
<p>Development of Drug Dual-Carriers Delivery System with Mitochondria-Targeted and pH/Heat Responsive Capacity for Synergistic Photothermal-Chemotherapy of Ovarian Cancer</p>
... a drug dual-carriers deliv- ery system (DDDS) based on common-used drug carriers, ferritin (FRT) and nanoscale graphene oxide ...excellent drug carrier as it has a large surface area, good ... See full document
13
Synergistic effect of PST and Tamoxifen in inducing apoptosis by targeting the mitochondria and insights into novelty of PST induced apoptosis
... Synergy of pancratistatin and tamoxifen on breast cancer cells in inducing apoptosis by targeting mitochondria.. Publication status*.[r] ... See full document
136
Stem cells: a model for screening, discovery and development of drugs
... stem cells offer an attractive high throughput screening platform for new target/ drug ...stem cells can be readily expanded in vitro and can be isolated from a variety of tissue sources, such ... See full document
9
Drug Discovery Approaches to Target Wnt Signaling in Cancer Stem Cells
... stem cells [104-106, 151-153]. CSCs are also thought to play a role in drug resistance and metastasis [16, ...to target CSCs. For example, colon cancer stem cells have been described to ... See full document
15
Biomarkers in Drug Discovery and Development: From Target Identification to Drug Marketing
... specific cells, molecules or genes, gene products, enzymes o ...prevention, drug target identification, drug response ...for drug target discovery as well as decision-making ... See full document
7
Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease
... disappointing. Cancer control is frequently short lived, even when these drugs are proven to be ...vemurafenib, cancer progression occurs within six months in the vast majority of these patients with V600E ... See full document
16
MRP1-CD28 bi-specific oligonucleotide aptamers: target costimulation to drug-resistant melanoma cancer stem cells
... tumor cells obtained directly from the primary tumor ...tumor cells coated ex vivo with bi-specific aptamer that binds to cell-surface protein on tumor cells (MRP1) while the other part of the ... See full document
15
RAS GTPase AS THE DRUG TARGET FOR ANTI CANCER DESIGNING OF DRUG FROM TEMPLATE
... RESULTS AND DISCUSSIONS: Eight ras GTPase complexes, 1K8R, 2KE5, 2UZI, 2VH5, 4GZL, 4GZM, 3GFT and 3TSO have been identified from the repository. By sequence analysis, the properties such as instability index, aliphatic ... See full document
5
Modelling arterial wall drug concentrations following the insertion of a drug-eluting stent
... governing drug release and distribution following stenting currently limits the opti- misation of such drug release ...the drug release ...experimental drug release of everolimus from a ... See full document
24
Replicating Parvoviruses That Target Colon Cancer Cells
... human cells raises biosafety concerns, but with adenovirus the immune system limits the number of cycles of virus replication so effectively that poor efficacy is a much more important barrier to the widespread ... See full document
9
DYNAMICS OF BIOINFORMATICS IN THE ARTIFICIAL DESIGNING OF DRUGS
... of drug design is to find a chemical compound that can fit to a specific cavity on a protein target both geometrically and ...a drug available to patients. The conventional drug design methods ... See full document
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