[PDF] Top 20 Mitochondrial uncoupling prevents cold induced oxidative stress: a case study using UCP1 knockout mice
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Mitochondrial uncoupling prevents cold induced oxidative stress: a case study using UCP1 knockout mice
... into mitochondrial functioning show that oxygen consumption is principally coupled with either energy conversion as ATP or as heat, depending on whether the ATP-synthase or the mitochondrial ... See full document
7
Insights into brown adipose tissue evolution and function from non model organisms
... high mitochondrial mass in brown adipocytes, which comprises up to 8% of total protein, provides the engine to harvest oxidation energy from lipids and glucose (Rousset et ...2004); mitochondrial ... See full document
9
Skeletal muscle mitochondrial uncoupling prevents diabetes but not obesity in NZO mice, a model for polygenic diabesity
... toward oxidative type 1 fibers (Couplan et ...SM mitochondrial uncoupling induces a metabolic remodeling as a result of compen- satory stress-signaling network that preserves cellular function ... See full document
11
Mitochondrial Deficiencies and Oxidative Stress in Parkinson's Disease: A Slippery Slope to Cell Death
... than oxidative stress ...leaky mitochondrial membrane generates increased free radicals. Thus, oxidative stress alone is not enough to explain PD ...including mitochondrial ... See full document
8
Abstract Cannabidiol is a well-known non-psychotropic phytocannabinoid from Cannabis sativa , which
... and oxidative damage to the neurons ...the study verified the activity of CBD in PD patients, where they showed CBD ameliorate the quality of life, reduced sleep disorder, provide antidepressant and ... See full document
35
Mitochondrial dysfunction induced by fatty acid ethyl esters, myocardial metabolites of ethanol
... mitochondrial oxidative phosphorylation correlated with the cleavage of fatty acid ethyl ester shown to be initially bound to mitochondria, with resultant generation of fatty acid, a potent uncoupler, in a ... See full document
9
Mechanisms of damage to the gastrointestinal tract from non steroidal anti inflammatory drugs
... In patients, strategies to alter or minimize a single biochemical effect of NSAIDs, such by co-administration of a phospholipid, esterification of NSAIDs (with or without the addition of nitric oxide or hydrogen sulfite ... See full document
54
A quest for the origin of mammal uncoupling proteins
... the UCP1 gene. We speculate that the search for marsupial UCP1 was not suc- cessful yet, since the sequence similarity to eutherian UCP1 can be expected to be rather ...of UCP1 ortho- logues ... See full document
10
Effect of obesity reduction on preservation of heart function and attenuation of left ventricular remodeling, oxidative stress and inflammation in obese mice
... J mice (n=24) were equally divided into control (fed a control diet for 22 weeks), obesity (high-fat diet, 22 weeks), and obese reduction (OR) (high-fat diet, 14 weeks; then control diet, 8 ...0.003). ... See full document
13
Antioxidant Effect of Epigallocatechin-3-Gallate in a Bleomycin-Induced Scleroderma Model
... previous study with approval of the Animal Care and Use Committee of the Dokuz Eylul University (Protocol No: ...This study was conducted at Dokuz Eylul University between April 2015 and May ...was ... See full document
8
NEUROPROTECTIVE ACTIVITY OF METHANOLIC EXTRACT OF ALPINEA GALANGA AGAINST EXCITOTOXICITY PRODUCED BY PTZ-INDUCED KINDLING MODEL IN MICE
... decreased in the brain tissue in the PTZk group in comparison with other groups. PTZ kindling-induced decrement in the SOD activity was prevented by MEAG (p=<0.0001). . The PTZ induced kindling ... See full document
12
Oxidative stress induced by lambda cyhalothrin in selected tissues of albino mice
... consumers. Oxidative stress by increased production of reactive oxygen species (ROS) has been implicated in the toxicity of various ...present study was designed to investigate the induction of ... See full document
5
Coenzyme Q10 partially restores pathological alterations in a macrophage model of Gaucher disease
... flux, mitochondrial dysfunction, inflammasome activation and efferocitosis capacity were examined in chemically-induced Gaucher THP-1 macro- ...as mitochondrial dysfunction and/or impaired ... See full document
15
Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin induced nephropathy in mice
... (BC) mice are shown, with segments homozygous for BALB alleles indi- cated in blue and segments with BALB/B6 genotypes indicated in ...BALB mice, with levels comparable to those of the B6.CB.17 mice ... See full document
11
Lycopene Supplementation Attenuates Oxidative Stress Parameters in the Plasma of Humans with Cad after Intense Exercise
... reducing oxidative stress in CVD and other chronic dis- eases ...decreased oxidative modification of LDL may be one of the mechanisms by which lycopene may reduce the risk of CVD and athero- ... See full document
8
Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet induced insulin resistant mice
... HFHSD mice were diabetic at 16 ...cle oxidative stress, probably because of an increase in both mitochondria and cytoplasmic ROS production rather than to a reduction in antioxidant ...striking ... See full document
13
Synergistic inhibition of autophagy and neddylation pathways as a novel therapeutic approach for targeting liver cancer
... this study provide a strong rationale for the further clinical evaluation of combination with clinically applicable autophagy inhibitors ...damage stress, excessive ROS production, transactivation of NOXA ... See full document
16
Treatment with Green Tea Prevents Intracerebroventricular Streptozotocin Induced Cognitive Impairment and Oxidative Stress in Mice
... in mice using passive avoidance paradigm when injected intracisternally ...the mice model of Parkinson’s ...of mice hippocampus, the learning site of brain [24] ... See full document
8
Original Article Ginsenoside Rg1 prevents MPP -induced apoptosis of SHSY5Y cells via the inhibition of a Bax-mediated mitochondrial pathway and by suppressing oxidative stress
... a mitochondrial permeability transition pore inhibitor, decreased the release of cyto- chrome c from the mitochondria, whereas the pretreatment with ...dopamine- induced generation of reactive oxygen ... See full document
9
Review article DPP-4/GLP-1 axis as a potential therapeutic target in chronic stress-related vascular aging and atherosclerosis
... large-scale case-control INTERHEART trial conducted in 51 countries demonstrated that chronic psychological stressors ...life stress, major life events, and low sense of control) pose an adjusted ... See full document
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