[PDF] Top 20 Mitotic phosphorylation by NEK6 and NEK7 reduces microtubule affinity of EML4 to promote chromosome congression
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Mitotic phosphorylation by NEK6 and NEK7 reduces microtubule affinity of EML4 to promote chromosome congression
... of NEK6 or NEK7 disrupts spindle formation in mitosis and both the kinesin Eg5 and the chaperone HSP72 have been reported as mitotic substrates of NEK6 (35, ...that EML4 should be added ... See full document
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Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression
... last chromosome congressed (left graph) and time from last chromosome congressed to anaphase onset (right ...YFP-EML4-FL, EML4-WT or EML4-S144/146A, for 24 hours before being treated ... See full document
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Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression
... Human EML4 is phosphorylated on serine/threonine residues in mitosis ...that EML4 undergoes phosphorylation at Ser 144 and Ser 146 in the N-terminal microtubule- binding region in mitosis and ... See full document
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FINDING NEW INHIBITORS FOR EML4-ALK FUSION PROTEIN: A COMPUTATIONAL APPROACH
... binding affinity of active inhibitors for the EML4-ALK, downloaded from ligand database to characterize interaction features using GLIDE (Schrodinger) and to interpret inhibition mechanism of small ... See full document
6
CHROMOSOME STUDIES OF PHLOX
... The ratio obtained by dividing the length of the short arm of a mitotic chromosome by the total length of the chromosome is used in this paper as a means of comparin[r] ... See full document
18
CRKL mediates EML4-ALK signaling and is a potential therapeutic target for ALK-rearranged lung adenocarcinoma
... tyrosine phosphorylation status were repressed by ALK inhibitors, we found significant enrichments of integrin signaling, focal adhesion kinase (FAK) signaling and paxillin/talin signaling (Figure 2B); these ... See full document
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CHROMATID ABERRATIONS INDUCED BY GAMMA IRRADIATION. I. THE STRUCTURE AND FREQUENCY OF CHROMATID INTERCHANGES IN DIPLOID AND TETRAPLOID CELLS OF VICIA FABA
... Chromosome polarity and chromosome movement during the mitotic cycle: The results from the experiments on diploid roots on the frequencies of the various interchange[r] ... See full document
19
Emerging roles of Nrf2 signal in non-small cell lung cancer
... receptor; EML4-ALK: echinoderm microtubule- associated protein-like anaplastic lymphoma kinase; ER: estrogen receptor; Gclm: glutamate-cysteine ligase modifier subunit; Gst: glutathione S-transferase; Ho-1: ... See full document
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Azaleodendrons: Investigating Parentage, Fertility, and Effects of Polyploidy Among Hybrids of Deciduous Azaleas and Evergreen Rhododendrons
... where chromosome doubling is completely ineffective at restoring fertility due to a different mode of ...by chromosome doubling and the meiotic irregularities observed in ‘Fragrant Affinity’ it can ... See full document
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The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation
... continuing chromosome segregation errors during division ...the mitotic checkpoint (also known as the spindle assembly checkpoint), a surveil- lance mechanism that operates in every division to prevent ... See full document
5
Chromosome congression is promoted by CENP Q and CENP E dependent pathways
... timely chromosome congression, as well as altering kinetochore–microtubule plus- end turnover, K-fibre stability and poleward microtubule flux (Amaro et ...kinetochore microtubule and, ... See full document
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USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis
... of chromosome instability (CIN) genes that play a disproportionally important tumor-suppressive role that is not necessarily related to the magnitude of aneuploidy produced in mutant ...or mitotic ... See full document
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Kinetochore dynamics and their attachment to the mitotic spindle
... the affinity of Ndc80 for microtubules This way individual NDC80 complexes bind more tightly towards the end of metaphase leading to a stabilisation of microtubule-kinetochore attachment (Zaytsev et ...by ... See full document
268
Comparison of mitotic cell death by chromosome fragmentation to premature chromosome condensation
... Although chromosome fragmentation is important to maintain system stability, there are many redundant sys- tems within cells that ensure that cells maintain home- ostasis and are not permanently damaged at the ... See full document
11
Epigenetic Aberrant Hypermethylation of DNA in Endometrial Cancer: Application as a Biomarker
... to microtubule inhibitors [24] (Figures 4 and ...If mitotic stress occurs during M phase, CHFR delays the progress from early prophase to late ...If microtubule stress occurs, CHFR is acti- vated, ... See full document
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Kuznetsova, Anastasia (2013): Transient tetraploidy as a route to chromosomal instability. Dissertation, LMU München: Fakultät für Biologie
... the microtubule plus-ends and regulate their ...proper chromosome alignment to the spindle (Kufer et ...aberrant mitotic spindle formation and chromosome segregation ... See full document
142
Control of microtubule assembly in 'Drosophila' and MDCK cells
... Microtubules of the mitotic spindle are apparently far more dynamic than those of the interphase microtubule array.. For example, fluorescence photobleaching recovery indicated that.[r] ... See full document
291
Class III β-Tubulin Counteracts the Ability of Paclitaxel to Inhibit Cell Migration
... suppressing microtubule dynamics with vinblastine did not stop migrating cells from extending a lamellipodium but rather appeared to inhibit the ability of the tail to retract ...[32]. Microtubule ... See full document
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Chromosome congression by CENP E and CENP Q dependent pathways
... Kinetochores are multi-protein megadalton assemblies that are required for attachment of microtubules to centromeres and, in turn, the segregation of chromosomes in mitosis. Kinetochore assembly is a cell cycle regulated ... See full document
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Hsp72 is targeted to the mitotic spindle by Nek6 to promote K fiber assembly and mitotic progression
... low Nek6 activity outside of mitosis but strongly stained spindle poles and sites of MT– kinetochore attachment in metaphase cells ...of Nek6 led to loss of Hsp72 from the mitotic apparatus that was ... See full document
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