[PDF] Top 20 Modulation of Different Human Immunodeficiency Virus Type 1 Nef Functions during Progression to AIDS
Has 10000 "Modulation of Different Human Immunodeficiency Virus Type 1 Nef Functions during Progression to AIDS" found on our website. Below are the top 20 most common "Modulation of Different Human Immunodeficiency Virus Type 1 Nef Functions during Progression to AIDS".
Modulation of Different Human Immunodeficiency Virus Type 1 Nef Functions during Progression to AIDS
... consensus nef alleles were cloned in a bicistronic expression vector containing nef followed by GFP under the control of an internal ribosome entry site IRES element ...the Nef proteins are expressed ... See full document
9
Dynamics and modulation of human immunodeficiency virus type 1 transcripts in vitro and in vivo.
... at different clinical stages (4, 5, 7, 14, 15, 49, 59, 64, 69, 73, ...disease progression in a large proportion of infected patients (7, 36, ...understanding AIDS pathogenesis but also for clinical ... See full document
11
Mutation of a Conserved Residue (D123) Required for Oligomerization of Human Immunodeficiency Virus Type 1 Nef Protein Abolishes Interaction with Human Thioesterase and Results in Impairment of Nef Biological Functions
... in Nef oligomers but not in the Nef monomer, D123 is interacting with the conserved diargi- nine motif R105-R106 of the opposite ...of Nef-induced CD4 downregulation and enhancement of viral ... See full document
10
Design and Use of an Inducibly Activated Human Immunodeficiency Virus Type 1 Nef To Study Immune Modulation
... early during an infection, since CD4 downmodulation appears to require a very small amount of active Nef-ER and occurs very rapidly (detectable in less than 2 ...of Nef- ER-dependent CD4 ... See full document
10
Human Immunodeficiency Virus Type 1 Nef Functions at the Level of Virus Entry by Enhancing Cytoplasmic Delivery of Virions
... The Nef protein of the type 1 human immunodeficiency virus (HIV-1) plays a key although poorly understood role in accelerating the progression of clinical disease ... See full document
8
Sequence Variations in Human Immunodeficiency Virus Type 1 Nef Are Associated with Different Stages of Disease
... Defective nef genes are rare in HIV-1 ...in nef, PCR amplification of nef LTR sequences was performed by using DNA extracted from PBMCs prepared from 165 patients (47 NPs, 90 SPs, and 28 RPs) ... See full document
12
Rodent Cells Support Key Functions of the Human Immunodeficiency Virus Type 1 Pathogenicity Factor Nef
... disease progression (re- viewed in reference 20). These functions include the removal and degradation of the primary entry receptor CD4 to prevent HIV superinfection and increase particle infectivity (6, ... See full document
11
Human Immunodeficiency Virus Type 1 Nef-Mediated Downregulation of CD4 Correlates with Nef Enhancement of Viral Pathogenesis
... The nef gene products encoded by human immunodeficiency virus type 1 (HIV-1) and simian immunodefi- ciency virus type 1 (SIV-1) increase viral ... See full document
10
Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.
... the Nef expression construct (pNef2) with the CD4 expres- sion vector (pCD4Neo) resulted in a 50 to 70% reduction in CD4 display on the cell surface ...of Nef is attrib- utable to enhanced endocytosis and ... See full document
10
Modulation of Sp1 Phosphorylation by Human Immunodeficiency Virus Type 1 Tat
... [Fig. 1]), we wished to examine the biolog- ical relevance of this contact during virus replication in ...for different portions of Tat were individually posi- tioned into the nef ... See full document
15
Contribution of Vpu, Env, and Nef to CD4 Down-Modulation and Resistance of Human Immunodeficiency Virus Type 1-Infected T Cells to Superinfection
... of Nef-mediated CD4 down-mod- ulation in preventing viral superinfection, we analyzed 10 ad- ditional HIV-1 nef alleles known to differ in their effects on CD4 ...NA7 Nef (26, 27, 34, 58) con- ... See full document
13
Dynamic Evolution of the Human Immunodeficiency Virus Type 1 Pathogenic Factor, Nef
... The human immunodeficiency virus type 1 (HIV-1) early gene nef is highly polymorphic (10, 25, 30, 38, ...the Nef gene product alters numerous pathways of T-cell ... See full document
10
Co infection by human immunodeficiency virus type 1 (HIV 1) and human T cell leukemia virus type 1 (HTLV 1): does immune activation lead to a faster progression to AIDS?
... with different HAART experiences and some authors believe that this may partially explain the divergence of results obtained ...clinical progression to AIDS in an African ... See full document
13
Slower evolution of human immunodeficiency virus type 1 quasispecies during progression to AIDS.
... (Fig. 1, lanes labeled C on the right sides of the ...from different time points were ...displayed different HTA patterns at adjacent time points throughout their asymptomatic infection ...CD4 ... See full document
11
Modulation of Cellular Protein Trafficking by Human Immunodeficiency Virus Type 1 Nef: Role of the Acidic Residue in the ExxxLL Motif
... The nef gene of primate lentiviruses is required for high-level viremia and the efficient pathogenesis of AIDS (12, 25, ...of Nef on the cellular protein trafficking environment. Nef alters ... See full document
13
Induction of AIDS in Rhesus Monkeys by a Recombinant Simian Immunodeficiency Virus Expressing nef of Human Immunodeficiency Virus Type 1
... HIV-1 nef can clearly substitute for SIVmac nef in this relevant animal model, we were not able to achieve moderate or high virus loads and disease progression in a workable time frame ... See full document
12
Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes.
... and Nef induce CD4 endocytosis, it is likely that they act according to different ...to Nef (2, ...two modulation path- ways by showing that in contrast to phorbol esters, when CD4 is ... See full document
10
Selection for Human Immunodeficiency Virus Type 1 Recombinants in a Patient with Rapid Progression to AIDS
... with different population sizes, N, assuming a generation time of ...from different blood compartments and/or different time ...white type on a black ... See full document
11
CD4 down-modulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef.
... The human immunodeficiency virus type 1 (HIV-1) genes vpu, env, and nef have all been implicated in modulating the levels of cell surface CD4 on infected ...CD4 ... See full document
10
Separation of Human Immunodeficiency Virus Type 1 Replication from nef-Mediated Pathogenesis in the Human Thymus
... talized human T-cell lines. The different selective pressures in vitro have led to the generation of variants with attenuated replication and pathogenicity in vivo ...the functions of some genes, ... See full document
9
Related subjects