[PDF] Top 20 Modulation of the Brd4/P-TEFb Interaction by the Human T-Lymphotropic Virus Type 1 Tax Protein
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Modulation of the Brd4/P-TEFb Interaction by the Human T-Lymphotropic Virus Type 1 Tax Protein
... If Tax increases the amount of active LMW P-TEFb com- plex, one might expect a concomitant decrease in the level of HMW P-TEFb ...the Tax could affect the binding of 7SK snRNA to ... See full document
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Interaction of the human T-lymphotropic virus type 1 Tax dimer with CREB and the viral 21-base-pair repeat.
... ternary Tax–CREB–21-bp-repeat com- plex involves highly specific protein-protein and protein-DNA ...with Tax in vitro (2, ...recruit Tax have been identified by in vitro ... See full document
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Human T-Lymphotropic Virus Type 1 p30IIRegulates Gene Transcription by Binding CREB Binding Protein/p300
... HTLV-1 Tax. Tax is critical for high-level HTLV-1 transcription and ...expression, Tax participates in a series of protein-protein and protein-DNA interactions, ... See full document
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Stimulation of Cyclin-Dependent Kinase Activity and G1- to S-Phase Transition in Human Lymphocytes by the Human T-Cell Leukemia/Lymphotropic Virus Type 1 Tax Protein
... tetracycline-mediated tax suppression, OMK-637 cells were infected with virus stocks diluted 1:10 with minimal essential ...growing human T cell line SS8BPT was infected with the ... See full document
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Imbalanced expression of glutamate-glutamine cycle enzymes induced by human T-cell lymphotropic virus type 1 Tax protein in cultivated astrocytes.
... the modulation of GS and GDH expression by HTLV-1, the presence of transcripts was mon- itored in RNA isolated from untreated Dev cells and from Dev cells after cocultivation with HTLV-1-producing ... See full document
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Immortalization of T Lymphocytes by Human T-Cell Leukemia Virus Type 1 Is Independent of the Tax-CBP/p300 Interaction
... the tax gene that results in a Tax protein which is incapable of activating the NF-B path- ...different Tax mutant, designated M22 (50, ... See full document
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Coactivator-Associated Arginine Methyltransferase 1 Enhances Transcriptional Activity of the Human T-Cell Lymphotropic Virus Type 1 Long Terminal Repeat through Direct Interaction with Tax
... in Tax transactivation was to utilize an siRNA to knock out expression of ...with Tax and CARM1 in the presence or absence of CARM1 siRNA ...transfected, Tax transactivation was observed (lane 4). ... See full document
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Induction of Cell Cycle Arrest by Human T-Cell Lymphotropic Virus Type 1 Tax in Hematopoietic Progenitor (CD34+) Cells: Modulation of p21cip1/waf1 and p27kip1 Expression
... Tax1 fails to alter endogenous survivin expression. Survivin, originally identified as an inhibitor of apoptosis (IAP) protein, plays a pivotal role in initiating entry into the cell cycle in human CD34 ⫹ ... See full document
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XBP-1, a Novel Human T-Lymphotropic Virus Type 1 (HTLV-1) Tax Binding Protein, Activates HTLV-1 Basal and Tax-Activated Transcription
... binding protein 1 (XBP-1), a basic leucine zipper transcription factor, plays a key role in the cellular unfolded protein response ...21-bp Tax-responsive element of the human ... See full document
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Differences in the Ability of Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) and HTLV-2 Tax To Inhibit p53 Function
... wild type in the HTLV-2-immortalized or -transformed cell lines tested (MO, C19, and Pyg220), but there is no response to ionizing radiation, we checked whether this phenomenon also correlated with the ... See full document
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Human T-Lymphotropic Virus Type 1 Oncoprotein Tax Promotes S-Phase Entry but Blocks Mitosis
... between Tax and hsMAD1 causes a spindle checkpoint defect that was proposed to be the cause of aneuploidy, microsatellite instability, and formation of multinucleated giant ...a Tax-expressing plasmid form ... See full document
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The Human T-Lymphotropic Virus Type 1 Tax Protein Inhibits Nonsense-Mediated mRNA Decay by Interacting with INT6/EIF3E and UPF1
... HTLV-1 Tax protein has been described as a potent trans- activator of provirus expression but also as an immortalizing pro- tein with pleiotropic ...of Tax: the inhibition of the NMD pathway. ... See full document
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Tax Interacts with P-TEFb in a Novel Manner To Stimulate Human T-Lymphotropic Virus Type 1 Transcription
... the interaction of Tax and P-TEFb in ...FIG. 1. CDK9 kinase activity is required for Tax transactivation in vivo and in ...(A) Tax transactivation is decreased by CDK9 ... See full document
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Human T-Lymphotropic Virus Type 1 Tax Protein Complexes with P-TEFb and Competes for Brd4 and 7SK snRNP/HEXIM1 Binding
... whether Brd4 levels affect virus pro- ...mature virus released into the su- ...to Brd4. As shown in Fig. 6C, virus production increased with ...in virus production between siRNA ... See full document
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Human T-Lymphotropic Virus Type 1 Mitochondrion-Localizing Protein p13II Is Required for Viral Infectivity In Vivo
... binding protein 2 (CREB-2) (17), JunD (40), JunB, and c-Jun (3), and is a negative regulator of Tax-mediated viral transac- tivation ...(17). Tax-dependent viral gene expressions from both ... See full document
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Human T-Lymphotropic Virus Type 1 Transcription and Chromatin-Remodeling Complexes
... the Tax/SWI/SNF interaction in vitro. We next asked if Tax binding to SWI/SNF could accel- erate nucleosome remodeling in ...purified Tax protein ...of Tax, SalI cleavage was ... See full document
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Induction of tumor necrosis factor alpha in human neuronal cells by extracellular human T-cell lymphotropic virus type 1 Tax.
... a 1:60 dilution of Matrigel (Collaborative Research, Cambridge, ...containing 1 m M cytosine arabinoside, 10 m M fluorodeoxyuridine, and 10 m M uridine as mitotic ...for 1 week in the presence of ... See full document
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Quantification of the virus host interaction in human T lymphotropic virus I infection
... of Tax expression i.e. into subjects with a high or low proportion of Tax+CD4+ cells at a given proviral load after 18 h ...of Tax expression (high fre- quency of Tax+ cells at a give proviral ... See full document
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Induction of p21CIP1/WAF1expression by human T lymphotropic virus type 1 Tax requires transcriptional activation and mRNA stabilization
... by Tax and the lack of increased p21 protein stabilization prompted us to examine the rate of p21 mRNA turnover by real-time ...the Tax-responsive 21-bp-repeat. Therefore, the efficiency of ... See full document
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Differential Expression of Nur77 Family Members in Human T-Lymphotropic Virus Type 1-Infected Cells: Transactivation of theTR3/nur77 Gene by Tax Protein
... infected T cells secreting Tax protein ...cellular Tax is able to modulate gene expression in a way similar to that of cytokines (3, 23, 24), and it has been shown to induce neurons to produce ... See full document
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