[PDF] Top 20 The molecular basis of T cell acute lymphoblastic leukemia
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The molecular basis of T cell acute lymphoblastic leukemia
... stem cell development expressed in hematopoietic progenitors, mast cells, and erythroid and mega- karyocyte progenitors ...of T-ALL cases as a result of various chromo- somal rearrangements (1, ...childhood ... See full document
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Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia
... various T-cell malignancies and appear to correlate with a relatively high intracellular concentration of ara-GTP compared to ...refractory T-cell acute lymphoblastic ... See full document
10
EZH2 is increased in paediatric T-cell acute lymphoblastic leukemia and is a suitable molecular target in combination treatment approaches
... 20 % of patients with favorable features as hyperdi- ploidy > 50 chromosomes or TEL-AML1 fusion con- tinue to suffer recurrences for their leukemia [21]. Moreover, inactivation of the p53 gene through muta- ... See full document
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Renal Calculi: An Unusual Presentation of T-Cell Acute Lymphoblastic Leukemia
... and acute renal failure secondary to spontaneous tumor lysis syndrome in the setting of T-cell acute lymphoblastic ...and acute renal failure when found in conjunction with ... See full document
6
Induction of human B cell antigens in non T cell acute lymphoblastic leukemia
... non-T cell ALL lines ...promyelocytic leukemia line or a T cell lymphoblastic leukemia ...non-T cell ALL lines, cytoplasmic mu-heavy chain (c mu) became ... See full document
11
T cell receptor delta gene rearrangements in acute lymphoblastic leukemia
... analyzed T cell receptor (TCR) delta gene rearrangement in 19 patients with T cell acute lymphoblastic leukemia (T-ALL) and 29 patients with B-precursor ...CD3- ... See full document
10
Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas
... human T cell acute lymphoblastic leukemia (T-ALL) [1–3] and several murine T-ALL models, including ATM − / − thymic lymphomas [4 – ...murine T-ALLs retain at least ... See full document
5
SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines
... human leukemia/lymphoma cell lines tested, only the T-ALL cell line LOUCY and the AML cell line MEGAL expressed the SET(TAF-Iβ)-NUP214 fusion gene ...the cell lines also ... See full document
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Speed of leukemia development and genetic diversity in xenograft models of T cell acute lymphoblastic leukemia
... manuscript. Cell sorting and analysis was performed by Nathalie Dechamps at the common fl ow cytometry platform of ...of Molecular Genetics of Robert Debré hospital, led by Hélène ... See full document
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Andrographolide inhibits growth of human T-cell acute lymphoblastic leukemia Jurkat cells by downregulation of PI3K/AKT and upregulation of p38 MAPK pathways
... Notes: (A) Jurkat cells were treated with different concentrations of andro for 48 hours. later, the cells were washed with 1× PBs and harvested on ice. lysates were prepared in a lysis buffer, and then subjected to ... See full document
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Phenothiazines induce PP2A mediated apoptosis in T cell acute lymphoblastic leukemia
... of T-ALL cells through a number of mechanisms, including downregulation of MYC (6, 8, 59), IL-7R (55, 60), and IGF-R1 (57), and suppression of PI3K/AKT signaling ...Notch-dependent T-ALL cells, consistent ... See full document
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Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies
... protein. T-ALL cells were treated with IRAK1/4 inhibitor, TLR1-TLR2 ligand, or DMSO, followed by the addition of cycloheximide (CHX), to inhibit protein translation over the course of 10 ... See full document
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Expression of the polycomb group gene Bmi1 does not affect the prognosis of pediatric acute lymphoblastic leukemia
... of acute myeloid leukemia, chronic myeloid leukemia, and myelo- dysplastic ...childhood acute lymphoblastic ...pediatric acute lymphoblastic ... See full document
6
xCELLigence system for real-time label-free monitoring of growth and viability of cell lines from hematological malignancies
... real-time cell analysis of adherent tumor ...The basis of its technology relies on the use of culture plates with gold microelectrodes located in their ...the cell culture surface with specific ... See full document
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WILMS' TUMOR GENE 1 (WT1) EXPRESSION IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA
... remission, molecular aberrations that could act as new prognostic factors, MRD markers and therapeutic targets are investigated with the aim to improve further the prognosis of patients with childhood ...in ... See full document
5
Targeting IRAK1 in T-Cell acute lymphoblastic leukemia
... T-cell acute lymphoblastic leukemia (T-ALL) represents expansion of cells arrested at specific stages of thymic development with the underlying genetic abnormality often ... See full document
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<p>T-lymphoid/myeloid mixed phenotype acute leukemia and early T-cell precursor lymphoblastic leukemia similarities with <em>NOTCH1</em> mutation as a good prognostic factor</p>
... Childhood Lymphoblastic Leukemia (GBTLI-ALL 99/09) or to ALL Berlin- Frankfurt- Münster (BFM-ALL 95 and 2002) ...and T-cell phenotype of both proto- ... See full document
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P53 mutation in acute T cell lymphoblastic leukemia is of somatic origin and is stable during establishment of T cell acute lymphoblastic leukemia cell lines
... with T cell acute lymphoblastic leukemia (T-ALL) were screened for mutations of the p53 tumor suppressor ...of T-ALL relapse patient ...B cell line (HABL) was ... See full document
8
Case Report B-acute lymphoblastic leukemia occurring in two pediatric patients with a history of prior Wilms tumors
... lineage leukemia (MLL) fusion gene was ...the cell cytoplasm was with rich red dye. Cell atypia and deeply stained nuclear were significantly ... See full document
10
Protein kinase inhibitors for acute leukemia
... AML cell by blocking the activity of c-KIT pharmaco- logically [17, ...Many molecular changes are being studied the prognitic impact in acute ...in acute leukemia (Table ... See full document
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