[PDF] Top 20 Molecular Diagnostics in Clinical Microbiology

... the clinical sample simultaneously, unlike microscopy or culture ...any clinical relevance, since some micro-organisms can both colonize and infect this anatomical ... See full document

... broad-range molecular diagnostics hold the promise of decreased time to results and increased sensitivity compared to growth-based blood culture systems but have not yet been fully ...existing ... See full document

... FDA-cleared molecular diagnostic test platforms available for the detection of microorganisms that represent simple, sample-in, answer-out systems with tests of moderate to low complexity (Cepheid, Idaho ... See full document

... Its clinical significance, especially over the last 15 years, has been propelled by its remarkable ability to up regulate or acquire resistance determinants, making it one of the organisms threatening the current ... See full document

... conceptually be considered a sensitivity ratio (true-positive rate [TPR]), which is defined as the proportion of isolates assigned to a species by the reference method that were correctly identified by the system under ... See full document

... with clinical signs of the disease, typically acute flaccid paralysis (AFP), with the need to confirm or exclude an aetiology of ...poliovirus, molecular characterization of isolates and referral of ... See full document

... The clinical laboratory of the regional medical center serves as the reference laboratory for primary care clinics and com- munity hospitals in eastern Missouri and west-central Illinois as well as providing ... See full document

... trigger clinical adverse symptoms, although nonallergic in origin, being similar in clinical presentation to true IgE-mediated allergic ...atypical clinical history or an inconsistent history always ... See full document

... from clinical specimens has certainly presented pros- pects for rapid availability of results that might enhance patient ...evaluating microbiology devices, comparisons can be made either to a ... See full document

... Screening for MRSA and VRE. Methicillin-resistant Staph- ylococcus aureus (MRSA) and vancomycin-resistant entero- cocci (VRE) are important nosocomial pathogens and a major target of infection control practices in the ... See full document

... medical microbiology diagnostics, we first extracted sequence information for species identification, antibiotic resis- tance, toxin gene presence, and classical genotypic typing (spa typing) from the 13 ... See full document

... sandwiched between seals that shuttles a DNA binding membrane between different reactions. Thus, size and volumes of reagents can be increased without increasing dead volumes. This design is easily automated, and ... See full document

... a clinical microbiologist are related to “amazing disruptive technologies” and the discovery of ...example, molecular assays now allow us to use just a tiny amount of clinical material to produce a ... See full document

... Wrena Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London, United Kingdoma; UCL Centre for Clinical Microbiology, University College London, [r] ... See full document

... 3 microbiology TLA solutions in use or in development (listed in alphabetical order by manufacturer): Kies- tra TLA (BD Kiestra ...(Copan Diagnostics, Murrieta, ... See full document

... Most clinical trials that use molecular imaging rely on relative or semiquan- titative approaches, since absolute quantitation methods using radionuclides are very complex and impractical for routine ... See full document

... Cystic fibrosis (CF) predisposes patients to bacterial colonization and infection of the lower airways. Several species belonging to the genus Burkholderia are potential CF-related pathogens, but microbiological ... See full document

... Titanium dioxide nanoparticles (Nano-TiO2) provides promising application as targeted cancer therapeutics. Further, understanding on the ideal physio-chemical properties are crucial for efficient clinical ... See full document

... Over the past century, antimicrobial susceptibility testing (AST) has been dominated by phenotypic approaches. Assays are largely based on the detection of microbial growth. These strategies uti- lize solid or liquid ... See full document

... have clinical utility for prenatal diagnosis and this study show s that the probes now routinely used in the laboratory, unlike other p ro b es in v e s tig a te d in th is stu d y a n d e lsew h e re can ach iev ... See full document