[PDF] Top 20 Molecular pathogenic pathways in extranodal NK/T cell lymphoma

... immune cell pheno- types and their spatial relationship, thus providing valuable and fundamental information necessary for the develop- ment of better cancer immunotherapy [114, ... See full document

... as extranodal NK/T- cell lymphoma-associated HLH and treated in Shanghai Cancer Center, China from January 2006 to July 2017, were included in this retrospective ...of ... See full document

... Extranodal NK/T-cell lymphoma, nasal type (ENKL) is a subtype associated with Epstein-Barr virus (EBV) infection and commonly involves the upper respiratory tract, such as the nasal ... See full document

... Extranodal NK/T-cell lymphoma nasal type (ENKL) is a rare type of non-Hodgkin lymphoma that more frequently occurs in East Asia and Latin ...its molecular background has ... See full document

... the NK/T-cell type as proven by immu- nohistochemical, flow cytometry, or EBV in situ hybridization ...with extranodal NK/T-cell lymphoma without lymphomatous ... See full document

... Extranodal NK/T-cell lymphoma, nasal type (ENKL), is an uncommon subtype of EBV associated lymphoma usually characterized by aggressive clinical ...and T-cell EBV ... See full document

... The main clinicopathologic characteristics of patients with ENKTL were shown in Table 1. All ENKTL patients showed positive staining for CD3, TIA-1 and EBER-1 and negative staining for CD20. CD56 expres- sion was present ... See full document

... of T cell specific for HLA-A2 re- stricted epitopes in LMP1 and LMP2 was analyzed by staining with HLA-A2 tetramers assembled with synthetic peptides origin from LMP1 YLQQNWWTL and LMP2 FLYALALLL, ... See full document

... Relatively, ANKL is a more aggressive disease than ENKTL and often presents a more rapid clinical course despite the poor outcomes of both diseases [7]. As previ- ously reported, most cases of ANKL were diagnosed from ... See full document

... negative in stromal cells of the tumor tissue although nor- mal lymphocytes adjacent tumor tissue showed positive expression of CXCL13. In contrast, the tumor cells did ex- press CXCR5 (Figure 2B). The serum CXCL13 was ... See full document

... in cell cycle control, apoptotic response and DNA repair, such as checkpoint kinase 2 (Chk2), ...to cell senescence and apoptosis, resulting in delay or prevention of tumorigenesis [26, ... See full document

... ENKTL is a highly aggressive lymphoma. Fortunately, asparaginase-based regimens significantly improve the prognosis [24]. The rationale behind using asparaginase agents as an anti-cancer treatment is that normal ... See full document

... (stage III/IV), the clinical course is highly aggressive, with frequent CT resistance and poor outcome. CHOP- based therapy [18,19] was often used, but associated without satisfactory results. However, recent combin- ... See full document

... distinctive T-/NK-cell lym- phoma characterized by tissue necrosis, frequent angioinvasion, EBV association, expression of cytotoxic molecule (TIA-1), cytoplasmic CD3, and CD56 but lack- ing ... See full document

... Our data provide evidence for the downregulation of PRDM1 by miR-223 at the post-transcriptional level as part of the pathogenesis of EN-NK/T-NT. First, the level of the PRDM1 expression was reciprocal to ... See full document

... Finally we studied the effects of Icaritin on EBV latent- lytic switch in ENKL cells by analyzing the mRNA ex- pression of three lytic-phase genes and one latent-phase gene. The three lytic-phase genes included the two ... See full document

... killer lymphoma (PINK), which includes age > 60 years, stage III or IV disease, distant lymph node involvement, and nonnasal disease, is used as a prognostic model for patients with ENKTL ... See full document

... killer/T-cell lymphoma (nasal type, ENKTL) is a relatively rare type of malignant lymphoma that is highly ...of NK/T-cell ...of NK/T-cell ... See full document

... CHL, extranodal NK/T cell lymphoma (ENKTCL) and BL ...of lymphoma in children and adolescents in South China is worthy of ... See full document

... of extranodal NK/T-cell lymphoma appear to be genuine NK-cell neo- plasm, while some cases show cytotoxic T-cell ...cytotoxic T-cell lym- phoma ... See full document