[PDF] Top 20 A Mosaic Genetic Screen Reveals Distinct Roles for trithorax and Polycomb Group Genes in Drosophila Eye Development
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A Mosaic Genetic Screen Reveals Distinct Roles for trithorax and Polycomb Group Genes in Drosophila Eye Development
... additional genes, sightless and hyperplastic responsible for other aspects of the Pc and E(z) pheno- discs, encode novel components of the Hh pathway (Lee types, we generated clones ectopically expressing UAS- and ... See full document
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The enhancer of trithorax and polycomb gene Caf1/p55 is essential for cell survival and patterning in Drosophila development
... a screen in Drosophila for dominant modifiers of a disorganized eye phenotype caused by overexpression of senseless (Pepple et ...complementation group S(ls)3, comprising three ... See full document
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Genome-wide RNAi screen in Drosophila reveals Enok as a novel trithorax group regulator
... [1–3]. Genetic analyses in Drosophila discov- ered two groups of genes, the Polycomb Group (PcG) and the trithorax Group (trxG), that contribute to the maintenance of ... See full document
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Role of Bmi 1 in Epigenetic Regulation during Early Neural Crest Development
... crest development, we performed in vivo loss-of-function experiments by antisense morpholino (MO) ...PcG genes do not exhibit severe defects or embryonic lethality (Chamberlain et ... See full document
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The Dynamic Partnership of Polycomb and Trithorax in Brain Development and Diseases
... Hox genes during ...720 genes identified with differential H3K4me3 levels, 616 genes had reduced H3K4me3 in HD brains relative to control healthy brains ... See full document
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ISOLATION AND CHARACTERIZATION OF SEX-LINKED FEMALE-STERILE MUTANTS IN DROSOPHILA MELANOGASTER WITH SPECIAL ATTENTION TO EGGSHELL MUTANTS
... Roles of ecdysone in Drosophila development. Organization of a cluster of four chorion genes in Drosophila and its relationship to developmental expression and amplificatio[r] ... See full document
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A genetic mosaic screen of essential zygotic genes in Caenorhabditis elegans.
... A class I mutation would not have a class I11 mutation would have a restricted focus: le- restricted focus: no early blastomeres may be mutant, thality results only if a[r] ... See full document
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A Genetic Screen to Identify Components of the sina Signaling Pathway in Drosophila Eye Development
... A genetic screen for dominant enhancers and suppressors of this phenotype identified mutations in a number of genes required for normal eye develop- ment, including UbcD1 , which encode[r] ... See full document
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Comparison of germline mosaics of genes in the Polycomb group of Drosophila melanogaster.
... Polycomb like (Pcl): The Abd-B expression of Pcl ma- ternal and zygotic mutants shows some tissue specificity.. In early embryos there is moderate misexpression in the epide[r] ... See full document
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Drosophila ptip is essential for anterior/posterior patterning in development and interacts with the PcG and trxG pathways
... regulatory genes is supported by ChIP studies in cell ...target genes that are activated upon loss of PC and PH ...repressed genes, mPTIP only bound to DNA upon loss of Pc and ph ...target ... See full document
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Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8
... gene products, whereas the wild-type (+/+) MEFs were unaffected. Lamin B was used as a control. (Bottom) The expression of Hoxb8 was induced by infection of Cre-expressing adenovirus vector in Rnf2 fl/fl MEFs (fl/fl), ... See full document
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Identification of Polycomb and trithorax group responsive elements in the regulatory region of the Drosophila homeotic gene Sex combs reduced.
... Sequences in the 10.0 UuI fragment repress ectopic Scr reporter gene expression in a Pc-G genedependent manner during embryogenesis: The gene products en- coded by Pc-G [r] ... See full document
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Genetic mosaic techniques for studying Drosophila development
... The trick to generating mosaics using this system is to restrict the expression of Gal4. In a few cases, this has been achieved by making constructs that employ promoters and enhancers from known genes (e.g. ... See full document
8
Architectural and Functional Diversity of Polycomb Group Response Elements in Drosophila
... Studies of evolutionary conservation of transcription- factor-binding sites in the 12 sequenced species of Drosoph- ila have proven to be a very valuable tool in the study of enhancers; however, they have not been as ... See full document
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Mutations in the Drosophila melanogaster Gene Encoding S-adenosylmethionine Suppress Position-Effect Variegation
... In Drosophila melanogaster, the study of trans-acting modifier mutations of positioneffect variegation and Polycomb group (PC-G) genes have been useful tools to investi[r] ... See full document
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Combined modulation of polycomb and trithorax genes rejuvenates β cell replication
... of polycomb proteins in β cells (18, ...the trithorax group (TrxG) protein complex that contains Mll1, a histone methyltrans- ferase that catalyzes trimethylation of H3K4 ... See full document
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A role of polycomb group genes in the regulation of gap gene expression in Drosophila.
... Other Polycomb group genes are also involved in the maternal to zygotic transition of gene expression: Based on the similar homeotic phenotypes of PC-G genes, it [r] ... See full document
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A Screen for New Trithorax Group Genes Identified little imaginal discs, the Drosophila melanogaster Homologue of Human Retinoblastoma Binding Protein 2
... homeotic genes during early embryogene- The Polycomb (Pc) gene was originally identified by sis, ...rule genes (Akam mutation that causes sex comb teeth to form on the ...male Drosophila ... See full document
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A Genetic Screen to Identify Genes Required for Drosophila Midline Development
... reporter genes in embryos of Drosophila ...twelve Drosophila species examined, suggests that any changes within this conserved region might reduce midline ...a group of midline neurons, ... See full document
194
Regulation of cellular plasticity in Drosophila imaginal disc cells by the Polycomb group, trithorax group and lama genes
... In Drosophila, three experimental systems have provided opportunities to investigate the mechanisms that lead to switches of determined ...normal development, the homeotic genes are expressed in ... See full document
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