[PDF] Top 20 Multicompartmental Analysis of Cholesterol Metabolism in Man: CHARACTERIZATION OF THE HEPATIC BILE ACID AND BILIARY CHOLESTEROL PRECURSOR SITES
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Multicompartmental Analysis of Cholesterol Metabolism in Man: CHARACTERIZATION OF THE HEPATIC BILE ACID AND BILIARY CHOLESTEROL PRECURSOR SITES
... synthesized cholesterol and preformed ...mevalonic acid and [ 14 ...mevalonic acid revealed no precursor- product relationship between bile acid, biliary ... See full document
17
Multicompartmental Analysis of Cholesterol Metabolism in Man: QUANTITATIVE KINETIC EVALUATION OF PRECURSOR SOURCES AND TURNOVER OF HIGH DENSITY LIPOPROTEIN CHOLESTEROL ESTERS
... esterified cholesterol in ...complete bile fistula (maximally stimulated cholesterol metabolism) or an intact enterohepatic ...H]mevalonic acid; [ 14 C]cholesterol bound to ... See full document
15
Cholesterol kinetics in subjects with bile fistula Positive relationship between size of the bile acid precursor pool and bile acid synthetic rate
... quantitate cholesterol pools and transport pathways in blood and ...studying bile fistula subjects, using several types of isotopic preparations, simultaneous labeling of separate cholesterol pools ... See full document
17
Scavenger receptor class B type I is a multiligand HDL receptor that influences diverse physiologic systems
... acids, cholesterol, and other agents (11, 16, 19, ...(phospholipids, bile acids, cholesterol) and/or amounts of bile are altered by surgical bile diversion or bile duct ligation ... See full document
6
Human cholesterol 7α hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype
... five bile acid species measured present in a 24-hour stool ...cholic acid plus deoxycholic acid (derived from cholic acid by bacterial action in the gut) to chenodeoxycholic plus ... See full document
10
Characterization of hepatic low density lipoprotein binding and cholesterol metabolism in normal and homozygous familial hypercholesterolemic subjects
... in cholesterol biosynthesis, 3-hydroxy-3-methylglutaryl coenzyme A reductase was normal; however, the total hepatic cholesterol and cholesteryl ester content was significantly increased from 53 to ... See full document
9
ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice
... hybridization analysis and densitometric scanning demonstrated increased hABCA1 mRNA in the liver (four- and ninefold, respectively) and macrophages (three- and sixfold, respectively) of hABCA1-A Tg mice (Figure ... See full document
8
Mechanisms of gallstone formation in women Effects of exogenous estrogen (Premarin) and dietary cholesterol on hepatic lipid metabolism
... altered biliary bile acid composition [( CA + DCA]/CDCA increases, P less than ...stimulated cholesterol esterification (P less than ...dietary cholesterol stimulated the biliary ... See full document
11
Mutation of β glucosidase 2 causes glycolipid storage disease and impaired male fertility
... the metabolism of bile acid–glucose ...normal bile acid ...b-glucosidase acid 1 (GBA1) defective in subjects with the Gaucher’s form of lysosomal storage ... See full document
11
Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRβ deficient mice
... LXR-β and LXRα-deficient mice were created accord- ing to the strategy shown in Figure 1. We first gener- ated mutant mice by flanking two exons encoding the DNA-binding domain and the hinge region of the respective LXR ... See full document
10
Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRβ1 governed pathway
... in bile acid metabolism that lead to decreased bile pool hydrophobicity and diminished intestinal cholesterol ...the bile salt pump ...on cholesterol metabolism ... See full document
12
BODY CHOLESTEROL METABOLISM IN MAN I THE EQUILIBRATION OF SERUM AND TISSUE CHOLESTEROL
... Analyses of different areas of intima in the same patient, and comparison of intimal cholesterol specific activities in different patients who died at generally similar intervals after l[r] ... See full document
7
Differential effect of corn oil-based low trans structured fat on the plasma and hepatic lipid profile in an atherogenic mouse model: comparison to hydrogenated trans fat
... fatty acid in corn oil. It can reduce plasma total cholesterol and LDL-cholesterol [13,14], each of which is an established CHD risk ...fatty acid (MUFA) and PUFA compared to trans ...and ... See full document
7
Regulation of biliary cholesterol secretion in the rat Role of hepatic cholesterol esterification
... of bile salts in the solubilization and biliary excretion of cholesterol is well established, little is known about the intrahepatic determinants of biliary cholesterol ...increased ... See full document
13
The formation of abnormal bile and cholesterol gallstones from dietary cholesterol in the prairie dog
... of cholesterol gallstones, we fed 24 adult male prairie dogs a high cholesterol, egg yolk ...a cholesterol-free ...contained cholesterol, 77±14% by dry ...developed bile of altered ... See full document
10
Estimation of Cholesterol and Bile Acid Turnover in Man by Kinetic Analysis
... of cholesterol and bile acid turnover were determined from an analysis of the biliary lipids after a single intravenous injection of labeled ...miscible cholesterol pool to ... See full document
10
CHOLESTEROL METABOLISM IN MAN
... Of the administered cholesterol 39.6 per primarily as bile acids that cholesterol is excreted cent was eliminated by all routes of excretion in a into both the bile and the feces 1, 2.. [r] ... See full document
6
Regulation of rat biliary cholesterol secretion by agents that alter intrahepatic cholesterol metabolism Evidence for a distinct biliary precursor pool
... decreased biliary cholesterol secretion ...increased biliary cholesterol output 32% at 1 ...on biliary bile salt or phospholipid ... See full document
10
Biliary excretion of lecithin and cholesterol in the dog
... of cholesterol is coupled to lecithin transport, and that there is also a small amount of independent passive transport of cholesterol from membranes to ... See full document
15
Effects of acute changes of bile acid pool composition on biliary lipid secretion
... acids. Bile flow, cholesterol, and phospholipid output were linearly related to bile acid secretion in all experimental ...of cholesterol and phospholipids coupled to bile acids ... See full document
12
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