[PDF] Top 20 NDRG1 regulates neutral lipid metabolism in breast cancer cells

... downstream lipid biosynthesis and traffick- ing pathways in cancer ...cells. NDRG1 expression cor- relates with glycolytic metabolism and poor outcomes in breast ... See full document

... Our results demonstrated the regulation of NR6A1 on FAS and DGAT2 in HepG2 cells, both of which are key lipogenic enzymes and have been shown to drive caner development. It is well known that lipids are generated ... See full document

... LNCaP cells [40], an effect similar to progestins in breast cancer cells ...PCa cells both in vitro and in vivo, although it is warranted to determine which transcription factor(s) work ... See full document

... citrate metabolism, which can disrupt the bal- ance between glycolysis, FA biosynthesis, and purine ca- tabolism ...(Gln) metabolism with an apparently high uptake of Gln through up-regulation of ... See full document

... in Breast Cancer (AIB1) oncogene regulates transcription and is also a downstream mediator of IGF-I ...LCC6) breast cancer ...knockdown cells, leading to a reduction in the ... See full document

... Two days prior determination of agonist-mediated inhibition of forskolin-induced cAMP production, 20.000 c/w BT-474 were seeded in 96w plates in RPMI1640 containing 10% FBS, 4.5 g/l glucose, 2 mM glutamine, 5 mM HEPES ... See full document

... normal cells towards aerobic glycosis in cancer cells, which is called the Warburg effect [ 11 ...is lipid metabolism; it includes lipid syn- thesis, lipid degradation and ... See full document

... Five subtypes were originally described: two luminal subtypes (luminal A and luminal B), which are hormone-receptor positive; a HER-2 positive subtype; a basal-like [r] ... See full document

... Counts per minute of 'IC-acetate incorporated into neutral lipids per microgram of protein in MRC-5 cells infected with various strains of VZV (for full virus designations, see Materials[r] ... See full document

... Cancer cells exhibit a distinct metabolic profile as com- pared to it’s normal ...tumor cells proliferation and inadequate blood vessels formation, tumor microenviroments are characterized by ... See full document

... proliferating cells. Cells were seeded onto 96-well plates as described in the previous ...section. Cells were incubated with 10 µM BrdU for 4 h and fixed with ... See full document

... progenitor cells [ 111 ], the crosstalk between YAP/TAZ and Wnt occurred independently from the activation of the Hippo regulatory module, the negative controller of YAP/ ...from breast CSCs (BCSCs) ... See full document

... subdivides breast cancers into six major subtypes: luminal A, luminal B, Her2, claudin low, basal- like breast cancer and normal-like (Perou et ...stratify breast cancers according to their ... See full document

... normal cells to aerobic glycolysis in cancer cells [ 1 ...to cancer cells. One such mechanism is lipid metabolism, which involves lipid synthesis, lipid ... See full document

... Abstract: Cancer stem cells (CSCs) represent rare tumor cell populations capable of self-renewal, differentiation, and tumor initiation and are highly resistant to chemotherapy and ...tumor cells ... See full document

... the cells based on the study Conclusion The growing interest in biological actions of plant extracts is a consequence of, among others, an increasingly high incidence of various cancers and a need to find safe and ... See full document

... and breast cancer growth modulation of surgical interventions for breast cancer had a substantial influence on the ...during breast cancer surgery treatment in the luteal ... See full document

... LTED cells expressed ER at a decreased level and lost growth response to estradiol, while SUM44 LTED cells retained partial ER ...of lipid metabolism across all six independent ...LTED ... See full document

... ER+ breast cancers ...HER2+ breast cancer is the use of targeted therapies such as lapatinib, pertuzumab, and trastuzumab emtansine ...ER+ breast cancer as mentioned above), ERK ... See full document

... Huh-7.5 cells in which miR-27a was inhibited or overexpressed showed that miR-27a could target lipid metabolism signaling ...the lipid content (TG and TCHO) of Huh-7.5 cells was ... See full document