[PDF] Top 20 Neoadjuvant chemotherapy regimens in treatment of breast cancer: a systematic review and network meta-analysis protocol

... pooled treatment effect using GRADE (Grading of Rec- ommendation, Assessment, development and Evaluation) rating system ...of network meta-analysis, each treatment comparison has its ... See full document

... to review abstracts (Stage 1 screen) and full text reports (Stage 2 screen) from search results independently and in duplicate against the eligibility criteria using Distiller SR software (Ottawa, Canada) to ... See full document

... radiotherapy, meta- regression analyses were used to assess the effect of add- itional preoperative radiotherapy on the survival benefits and the result showed, relative to neoadjuvant chemo- therapy alone, ... See full document

... An evidence contribution plot was constructed to show the effect of comparing the results of different CRT regimens directly with the results of their NMA. The consistency was investigated within every closed loop ... See full document

... prior systematic review comparing the many possible immuno- suppression treatments for kidney transplant patients with regard to the occurrence of these ...Our review will provide a comprehensive ... See full document

... Japanese Breast Cancer Society criteria, and one used the Chevalier-Sataloff ...Japanese Breast Cancer Society grade 3, and Chevalier class 1, Sataloff A were classified as pCR in studies ... See full document

... pancreatic cancer is surgical resection, up to 85% of patients relapse after ...of neoadjuvant treatment in resectable pancreatic cancer (RPC) remains unclear and there is no systematic ... See full document

... anthracycline-based neoadjuvant chemotherapy (NAC) has been proposed to improve the pathologic complete response (pCR) rate, although there are conflicting views about its efficacy and ...of breast ... See full document

... platinum chemotherapy agents: the use of neodjuvant chemotherapy with cisplatin in BRCA 1 muta- tion TNBC patients accomplished a pCR rate of 61% ...included neoadjuvant chemotherapy with ... See full document

... This systematic review and meta-analysis was subjected to ...AI treatment are important because the limited data available have sug- gested that the most common reason for discontinuing ... See full document

... All authors had been trained to understand purpose of systematic review and know the methods of meta-analysis. Two authors (Fu-Gang Zhao and Chang-Peng Zou) were primarily responsible to read ... See full document

... pairwise meta-analyses of direct evidence were conducted by the fixed-effects model, with R version ...and network package were used for drawing the network ...random-effects network ... See full document

... applied neoadjuvant chemotherapy regimens, the total number of patients, mean age, tumor size, follow-up time, the number of patients who received BCS, the number patients who achieved CR, and the ... See full document

... (78.2%). Chemotherapy alone was used in 20 ...studies, chemotherapy with chemoradiation was used in 41 ...of chemotherapy agent utilized included FOLFIRINOX in 810 patients, GTX in 410 patients, ... See full document

... among cancer related medical specialities and the exchange of ideas arising from ongoing advances in ...to breast cancer was covered as well as new clinical data pertinent to breast oncology ... See full document

... two meta-analyses with the largest heterogeneity also showed that largest empirical differences between θ ˆ FE and θ ˆ RE ...the meta-analysis with the largest outward hetero- geneity, but with also ... See full document

... Two independent authors will perform all screening steps. Title and abstract screening will be conducted with the Mendeley citation management software. The overview authors will screen the titles and abstracts against ... See full document

... of treatment relative to controls, as this will allow us to synthesize data measuring the same outcomes ...work meta-analysis [24,25] as described further below will be used to explore comparisons of ... See full document

... Our review was identified by Canadian policy-makers as a priority topic of the health of ...our protocol in response to their query—a form of integrated knowledge ... See full document

... and cancer stem cell markers CD24 and CD44 (immunophenotypes: CD44 + /CD24 + ; CD44 + /CD24 -/low ; CD44 - /CD24 + ; CD44 - /CD24 -/low ) [16,32,33] (Table ... See full document