[PDF] Top 20 Neuraminidase-1: A novel therapeutic target in multistage tumorigenesis

... Other reports have provided supporting evidence for a role of Neu1 in the receptor glycosylation modification model in respiratory airway epithelia. Lillehoj et al. [49] have demonstrated that Neu1 associates with EGFR ... See full document

... open novel fields in biomarker research, in diagnosis, and in ...involved 1) as a biomarker in response or resistance to therapy or 2) as a therapeutic ... See full document

... Figure 3 Knockdown of nFaTc2 inhibits the stemness of crc cells. (A, B) sphere formation assay of nFaTc2-knockdown and control primary crc cells. Primary crc cells were isolated from the cancer tissues of crc patients ... See full document

... ATPase activity with V0 rotation [1]. Multiple roles have been attributed to V-ATPase in physiological conditions, among which regulation of pH balance, control of neurotransmitter trafficking and degradation of ... See full document

... Abstract: In the last decade, cancer research efforts in the field of noncoding microRNA (miRNA) have been growing exponentially. miRNA-based therapeutics have been tested in both preclinical and clinical settings, and ... See full document

... Although our understanding of their role in cancer is lim- ited, the expression of a variety of ribosomal proteins has been associated with the development of prostate and colon cancer. For example, we have previously ... See full document

... Since CRIPTO-1 physically interacts with all four Notch receptors and Notch4 and Cripto-1 has been shown to be relevant in embryogenesis, maintenance of a human BC stem cell population and ... See full document

... D4B is a valuable candidate as a novel biomarker in breast cancer. MAGE family genes were initially identified as genes encoding tumor-specific antigens, and since then MAGE type I genes have been extensively ... See full document

... potential therapeutic target by in-vitro overexpression, inhibition and knockdown ...predict therapeutic success since the small molecule inhibitors target the protein itself ... See full document

... (1992) Active nuclear import of human immunodeficiency virus type 1 preintegra- tion complex. Stevenson M, Bukrinsky M, Haggerty S[r] ... See full document

... Inhibition of antiviral effect of cytokines by SOCS in cultured myocytes. Given the importance of JAK-STAT signaling in the SOCS1 transgenic mice, we sought to determine whether cytokines that activate JAK- STAT ... See full document

... none; 1, <10%; 2, 10–50%; and 3, >50% of all cancer ...staining; 1, weak staining; 2, moderate staining; and 3, strong ...0, 1, 2, 3, 4, 6, and ... See full document

... Given that skeletal muscle is one of the major organs that contributes to insulin resistance it stands to reason that therapies directed to targets expressed in this tissue may offer novel approaches to treating ... See full document

... potential therapeutic target is Abelson helper integration site-1(Ahi-1/AHI-1) that was identified by retroviral insertional mutagenesis in murine models of leukemia/lymphomas and is ... See full document

... with vehicle or 11a-1, stained cell nucleus with Hoechst and monitored the mean moving distance of cells by an ArrayScan high-content screening system. As shown in Figure 4C, 11a-1 treatment ... See full document

... to 1 mg of protein depending on the experiment) using an azeotrophic mix of isopropanol:water:ethyl acetate (3:1:6; ...and 1-phosphates or a Supelco ... See full document

... HDACi are a novel class of structurally diverse natural and synthetic compounds that modulate a myriad of cellular functions by inhibiting HDAC activity. The ability of various HDACis such as LBH589 (Panobinostat, ... See full document

... cytes [1], but have also been found in several tissues, in- cluding pancreatic α- and ß-cells, smooth muscle, skeletal muscle and central neurons [2, 3]. The channels belong to the family of inwardly rectifying K ... See full document

... available therapeutic and lifestyle strategies, when optimized, increase HDL levels by ...Some novel therapeutic agents in human studies appear to increase HDL levels effectively, whereas other ... See full document

... IMPORTANCE Influenza virus is a common infectious agent causing serious sea- sonal epidemics, and there is urgent need to develop an alternative treatment modality for influenza virus infection. Recently, host-derived ... See full document