[PDF] Top 20 Neutralization Profiles of Primary Human Immunodeficiency Virus Type 1 Isolates in the Context of Coreceptor Usage
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Neutralization Profiles of Primary Human Immunodeficiency Virus Type 1 Isolates in the Context of Coreceptor Usage
... of human immunodeficiency virus type 1 (HIV-1) which have only been carried in vitro in peripheral blood mononuclear cells (primary isolates) can be neutralized by ... See full document
9
Patterns of CCR5, CXCR4, and CCR3 Usage by Envelope Glycoproteins from Human Immunodeficiency Virus Type 1 Primary Isolates
... vaccinia virus promoter linked to the indicated coreceptor genes and coinfected with vCB-3 (CD4) and vCB21R-LacZ; control cells were transfected with the empty pSC59 plasmid and infected ...cinia ... See full document
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Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120.
... sequenced virus strains in the test panel, except IIIB, contained the canonical 19b epitope (Table ...the primary strains in our panel at concentrations of # 25 m g/ml. Primary virus ... See full document
9
Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1.
... to coreceptor specificity (14), we reasoned that charged residues in the extracellular domains of CCR5 may be critically involved in the fusion mechanism and/or Env speci- ...dual-tropic primary isolate ... See full document
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Neutralization of primary human immunodeficiency virus type 1 isolates by the broadly reactive anti-V3 monoclonal antibody, 447-52D.
... To obtain the proper perspective in regard to hMAb 447-52D, HIV-1 gpl2O V3 region sequence analysis was performed on patient plasma when available, virus isolates, and DNA of PBMC cultur[r] ... See full document
7
CCR8 on Human Thymocytes Functions as a Human Immunodeficiency Virus Type 1 Coreceptor
... in human thymic implants ...HIV-1 isolates (5), it is possible that in addition to CXCR4 and CCR5, other coreceptors such as CCR8 play an important role in the infection of primary ... See full document
7
Stoichiometry of Antibody Neutralization of Human Immunodeficiency Virus Type 1
... ⫽ 1 neutralization stoichiometry is shared by all nine mono- clonal antibodies studied in this report; these antibodies ex- hibit a range of neutralization potencies and bind distinct el- ements on ... See full document
10
The Promiscuous CC Chemokine Receptor D6 Is a Functional Coreceptor for Primary Isolates of Human Immunodeficiency Virus Type 1 (HIV-1) and HIV-2 on Astrocytes
... on primary astrocytes, and siRNAs against D6 mRNA inhibited the infection of these cells by many of the same ...D6 usage by HIV-1 and -2 may be important for brain patho- ...other primary cell ... See full document
7
Use of Inhibitors To Evaluate Coreceptor Usage by Simian and Simian/Human Immunodeficiency Viruses and Human Immunodeficiency Virus Type 2 in Primary Cells
... several coreceptor-transfected GHOST- CD4 cell lines occurs via endogenous ...This coreceptor may well be expressed to different levels in different individual GHOST-CD4 cell lines, although we were unable ... See full document
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Heterogeneous Spectrum of Coreceptor Usage among Variants within a Dualtropic Human Immunodeficiency Virus Type 1 Primary-Isolate Quasispecies
... to coreceptor use, in order to begin to address the molecular regulation of individual coreceptor usage among related vari- ants of a dualtropic swarm, we generated two pairs of recip- rocal ...for ... See full document
7
Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG.
... are neutralization serotypes, and here again there does not appear to be a consistent cor- relation between HIV-1 neutralization patterns and the ge- netic clades (42, 57, ...general, primary ... See full document
9
Regional Clustering of Shared Neutralization Determinants on Primary Isolates of Clade C Human Immunodeficiency Virus Type 1 from South Africa
... selected isolates in these sex ...the virus into the country, with the diversity observed being greater than one would ex- pect from founder-type effects such as seen in Thailand (8, ...selected ... See full document
12
Antibodies with specificity to native gp120 and neutralization activity against primary human immunodeficiency virus type 1 isolates elicited by immunization with oligomeric gp160.
... Current human immunodeficiency virus type 1 (HIV-1) envelope vaccine candidates elicit high antibody binding titers with neutralizing activity against T-cell line-adapted but not ... See full document
12
Determination of Coreceptor Usage of Human Immunodeficiency Virus Type 1 from Patient Plasma Samples by Using a Recombinant Phenotypic Assay
... Human immunodeficiency virus type 1 (HIV-1) entry into target cells relies on a complex interaction between viral and cellular proteins, eventually leading to viral and plasma ... See full document
9
Primary Infection by a Human Immunodeficiency Virus with Atypical Coreceptor Tropism
... of human immunodeficiency virus type 1 (HIV-1) strains enter CD4 ⴙ target cells by interacting with one of two coreceptors, CCR5 or ...(T/F) virus (ZP6248) that was ... See full document
13
Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates.
... The ability of sCD4 to bind the oligomeric envelope glyco- protein complexes and to induce the dissociation of the gp120 glycoprotein from these complexes (29, 38) was examined by incubating radiolabeled COS-1 ... See full document
10
Microglia Express CCR5, CXCR4, and CCR3, but of These, CCR5 Is the Principal Coreceptor for Human Immunodeficiency Virus Type 1 Dementia Isolates
... of primary antibody was added per ...following primary antibodies diluted in staining buffer (PBS with ...a 1:10 dilution of an anti-major histocompatibility complex MHC class I monoclonal antibody ... See full document
9
N-Linked Glycosylation of CXCR4 Masks Coreceptor Function for CCR5-Dependent Human Immunodeficiency Virus Type 1 Isolates
... functional coreceptor for otherwise-restricted R5 isolate ...principal coreceptor, CCR5, does not appear to possess any N-linked glycosylation modifications, although there is a potential site in the ... See full document
10
Multivariate analysis of human immunodeficiency virus type 1 neutralization data.
... different isolates is ...and/or neutralization spectrum (Table ...HIV-1 isolates which have induced antibodies in potent gen- eralist sera, (ii) to characterize the possible common epitopes in ... See full document
9
No Selection for CCR5 Coreceptor Usage during Parenteral Transmission of Macrophagetropic Syncytium-Inducing Human Immunodeficiency Virus Type 1
... Human immunodeficiency virus type 1 (HIV-1) isolates can display differences in biological properties, such as replication rate, syncytium-inducing (SI) capacity, and ... See full document
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