[PDF] Top 20 Nonreplicating Influenza A Virus Vaccines Confer Broad Protection against Lethal Challenge
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Nonreplicating Influenza A Virus Vaccines Confer Broad Protection against Lethal Challenge
... 2.1) virus died, while 60% of the mice that received two doses of H5 S-FLU vaccine survived, and mice that received two doses of the H5 ca vaccine experienced minimal weight loss and survived ...the ... See full document
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A single dose of DNA vaccine based on conserved H5N1 subtype proteins provides protection against lethal H5N1 challenge in mice pre exposed to H1N1 influenza virus
... conventional vaccines, DNA vaccine has lots of ...pandemic vaccines. According to our previous studies, influenza DNA vaccines based on the surface protein, hemaggluti- nin or neuraminidase, ... See full document
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A baculovirus dual expression system based vaccine confers complete protection against lethal challenge with H9N2 avian influenza virus in mice
... In the present study, we developed a baculovirus dual expression system that possesses a gene cassette consist- ing of the chimeric HA gene under control of the CMV-polyhedrin dual promoter. We also investigated the ... See full document
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Incorporation of membrane bound, mammalian derived immunomodulatory proteins into influenza whole virus vaccines boosts immunogenicity and protection against lethal challenge
... Mouse-derived granulocyte macrophage-colony stimulat- ing factor (mGM-CSF) and interleukin 2 and 4 (mIL-2, mIL-4) were fused to a short stalk, transmembrane, and cytoplasmic tail domain of influenza A/WSN/33 ... See full document
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Acute Infection with Venezuelan Equine Encephalitis Virus Replicon Particles Catalyzes a Systemic Antiviral State and Protects from Lethal Virus Challenge
... defense against invading pathogens, inducing an antiviral state to impede the spread of ...encephalitis virus (VEE) replicon particles (VRP) to limit infection to the initially infected cells in vivo, a ... See full document
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Contributions of the Avian Influenza Virus HA, NA, and M2 Surface Proteins to the Induction of Neutralizing Antibodies and Protective Immunity
... RNA virus belonging to the genus Avulavirus in the family Paramyxo- ...protected against clinical disease after challenge with virulent NDV or ...the challenge virus was not observed, ... See full document
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Protection against Lethal Influenza with a Viral Mimic
... protection against homologous virus ...ral challenge, we used laboratory-adapted influenza A/Puerto Rico/ 8/1934 virus (H1N1; PR8) ...H3N2 virus, which carries the same ... See full document
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DNA Vaccine Encoding Hemagglutinin Provides Protective Immunity against H5N1 Influenza Virus Infection in Mice
... highly lethal H5N1 avian influenza virus was apparently transmitted directly from chickens to humans with no intermediate mammalian host and caused 18 confirmed infections and six ...this ... See full document
5
An M2e based synthetic peptide vaccine for influenza A virus confers heterosubtypic protection from lethal virus challenge
... to influenza type A virus replication in mice ...viral challenge to evaluate the efficacy of the M2e-based ...the challenge conditions used by various viruses to score protection after ... See full document
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Chimeric Hemagglutinin Constructs Induce Broad Protection against Influenza B Virus Challenge in the Mouse Model
... B virus lineages undergo rapid anti- genic drift, and vaccines have to be updated and readministered on an annual ...B virus lineages in modern quadrivalent influenza virus vaccines ... See full document
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A DNA Vaccine-Encoded Nucleoprotein of Influenza Virus Fails To Induce Cellular Immune Responses in a Diabetic Mouse Model
... lethal influenza pandemics, such as that of avian-flu A/H5N1 virus, it is evident that new vaccines are needed to ensure optimal protection against all strains of ... See full document
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Protection against a Lethal Avian Influenza A Virus in a Mammalian System
... virulent influenza A viruses (15), was detected in sam- ples of liver, spleen, and brain ...H3N8 virus is clearly very pathogenic for laboratory mice. Protection conferred by H3N2 ...protected ... See full document
7
Evaluation of Three Live Attenuated H2 Pandemic Influenza Vaccine Candidates in Mice and Ferrets
... efficacious against heterologous virus challenge in mice and fer- rets ...H2 influenza viruses to identify ad- ditional H2 vaccine candidates and selected a group of geograph- ically and ... See full document
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Vaccination with Adjuvanted Recombinant Neuraminidase Induces Broad Heterologous, but Not Heterosubtypic, Cross Protection against Influenza Virus Infection in Mice
... among influenza A virus NAs ...the influenza B virus neuraminidase (38, ...antibodies against the same epitope can be induced by natural infection or vaccination with influenza ... See full document
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Inactivated or Live-Attenuated Bivalent Vaccines That Confer Protection against Rabies and Ebola Viruses
... to confer protection from homologous EBOV species in ...vaccination, virus-like particles, or by expression from recombinant viruses, including adenovirus, vesicular sto- matitis virus (VSV), ... See full document
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A DNA Vaccine That Targets Hemagglutinin to Antigen-Presenting Cells Protects Mice against H7 Influenza
... the virus acquires the ability to transmit between humans. Novel vaccines that can be rapidly produced for global distribution are ur- gently needed, and DNA vaccines may be the only type of vaccine ... See full document
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Cross-protection among lethal H5N2 influenza viruses induced by DNA vaccine to the hemagglutinin.
... reliable protection against lethal influenza virus infection, while in chickens the same strategy has yielded variable ...immune protection to chickens challenged with ... See full document
6
Long-Term Protective Immunity from an Influenza Virus-Like Particle Vaccine Administered with a Microneedle Patch
... with influenza virus-like particles (VLPs) using microneedles has been shown to induce protection similar to or better than that induced by intramuscular ...100% protection against ... See full document
7
Pathogenicity and Vaccine Efficacy of Different Clades of Asian H5N1 Avian Influenza A Viruses in Domestic Ducks
... of influenza A viruses, including ...H5N1 influenza A viruses because they exhibit diversity in morbidity and ...strategy against endemic as well as pandemic influenza, it is important to ... See full document
9
Vesicular Stomatitis Virus Pseudotyped with Ebola Virus Glycoprotein Serves as a Protective, Noninfectious Vaccine against Ebola Virus Challenge in Mice
... of protection conferred by pseudovirions bearing GP1 that was partially (7G) or fully (7Gm8G) denuded of N-linked glycans ...the protection conferred against lethal challenge was ... See full document
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