[PDF] Top 20 A novel HPV16 E7-affitoxin for targeted therapy of HPV16-induced human cervical cancer
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A novel HPV16 E7-affitoxin for targeted therapy of HPV16-induced human cervical cancer
... a novel category of small affinity proteins with 7 kDa of molecular weight, have been developed and successfully applied to detect HER2-positive tumors in vitro and in xenografts ... See full document
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HPV16 synthetic long peptide (HPV16 SLP) vaccination therapy of patients with advanced or recurrent HPV16 induced gynecological carcinoma, a phase II trial
... of Human Papillomavirus (HPV) infec- tions in the development of gynecological cancers, in particular cervical intraepithelial neoplasia and cervical carcinoma, has been unambiguously ...early-stage ... See full document
14
Serine/threonine kinases 31(STK31) may be a novel cellular target gene for the HPV16 oncogene E7 with potential as a DNA hypomethylation biomarker in cervical cancer
... for cervical neoplasia [18–20] may be valuable for detecting cancer precursors early, reassuring candidates by reducing the frequency of screening, predicting the outcomes for women infected with hr-HPV, ... See full document
11
Proteomics-based identification of VDAC1 as a tumor promoter in cervical carcinoma
... in human papillomavirus (HPV)-related cervical cancer cells, in order to identify a potential target for gene ...HPV-positive cervical cancer ...of cervical cancer, the ... See full document
12
DETECTION HIGH RISK OF HUMAN PAPILLOMA VIRUS GENOTYPE (16/18) IN IRAQI WOMEN PATIENTS WITH CERVICAL CARCINOMA BY USING CHROMOGEN INSITU HYBRIDIZATION (CISH) TECHNIQUE
... to cervical neoplasia and ...of cervical cancer (Castle et al., 2011). HPV16 is the predominant HPV type of squamous cell cervical carcinomas and HPV18 predominates within ... See full document
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Integration of human papillomavirus 16 in esophageal carcinoma samples
... between human papillomavirus (HPV) infection and the development of esophageal ...and HPV16 was determined using type-specific primer sets for HPV16 ...The HPV16 integration site was verified ... See full document
9
HPV16 variant lineage, clinical stage, and survival in women with invasive cervical cancer
... in cervical cancer patients, there were interesting trends among 16- NE cases for some parameters that may reveal signifi- cance in a larger study with a larger population of 16- NE ... See full document
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Original Article Therapeutic and anti-metastatic effect of CIKs on cervical cancer enhanced by modified HPV16 E7-pulsed DCs with SOCS1-knockdown
... Abstract: Cervical cancer is the second most frequent cancer and the second most common cause of cancer- related deaths among women ...modified HPV16 E7 (HPV16mE7) with reduced ... See full document
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Phylogeny and polymorphism in the E6 and E7 of human papillomavirus: alpha-9 (HPV16, 31, 33, 52, 58), alpha-5 (HPV51), alpha-6 (HPV53, 66), alpha-7 (HPV18, 39, 59, 68) and alpha-10 (HPV6, 44) in women from Shanghai
... of cervical cancer, where greater than 99% of cervical cancer lesions contain HPV DNA ...and cancer is unclear ...of cancer progres- sion. For example, the HPV16 variant ... See full document
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Hypoxia inducible factor-1 alpha expression is increased in infected positive HPV16 DNA oral squamous cell carcinoma and positively associated with HPV16 E7 oncoprotein
... anti HPV16 E7 oncoprotein (Invitrogen Corporation, Camarillo, CA, USA), dilution 1:50, for 2 hours at 25°C or rabbit polyclonal anti-HIF- 1a (Novus Biologicals, Littleton, Co, USA), dilution 1:100, for 1 ... See full document
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Evidence for Alteration of EZH2, BMI1, and KDM6A and Epigenetic Reprogramming in Human Papillomavirus Type 16 E6/E7-Expressing Keratinocytes
... observers. Cervical intraepithe- lial neoplasia grade III lesions (CIN3 lesions; also called high-grade squamous intraepithelial lesions) were described and processed as previously described ... See full document
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Papillomavirus E7 Oncoproteins Share Functions with Polyomavirus Small T Antigens
... HPV16 E7 blocks myoblast differentiation. We next tested the effects of HPV16 oncoproteins on myoblast differentiation in the C2C12 ...of HPV16 oncoproteins in the same ...ST, HPV16 E6, ... See full document
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Mutational analysis of human papillomavirus type 16 E6 demonstrates that p53 degradation is necessary for immortalization of mammary epithelial cells.
... wild-type HPV16 E6 oligonucleotide to amplify a DNA fragment that contained the ...wild-type HPV16 E6 in pSP65, and the presence of the mutation was confirmed by DNA ... See full document
6
Chimeric L1-L2 Virus-Like Particles as Potential Broad-Spectrum Human Papillomavirus Vaccines
... the human papillomavirus (HPV) minor capsid protein L2 can induce low-titer, cross-neutralizing ...VLP induced higher L2-specific antibody titers than vaccination with corresponding sodium dodecyl ... See full document
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Carboplatin/paclitaxel, E7-vaccination and intravaginal CpG as tri-therapy towards efficient regression of genital HPV16 tumors
... designed to induce specific cytotoxic T-cell responses against tumor cells have shown impressive results in subcutaneous (s.c.) animal models. Initial application in humans has shown modest clinical effectiveness in the ... See full document
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Pre immature dendritic cells (PIDC) pulsed with HPV16 E6 or E7 peptide are capable of eliciting specific immune response in patients with advanced cervical cancer
... was not possible, the pulsed PBMCs were assayed alone to make sure they were not producing any spots. Briefly, the day before assay setup, 96-well polyvinylidene fluor- ide (PVDF) membrane, HTS opaque plates (Millipore, ... See full document
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Genome wide expression analysis in HPV16 Cervical Cancer: identification of altered metabolic pathways
... the Human Whole Genome CodeLink microarrays, which have the enough sensitivity to detect as little as one transcript per cell and the specificity to dis- tinguish among highly homologous ... See full document
10
Accumulation of human papillomavirus type 16 E7 protein bypasses G1 arrest induced by serum deprivation and by the cell cycle inhibitor p21.
... the HPV16 E7 oncoprotein in quiescent NIH 3T3 cells induces entry into S ...mutant HPV16 E7 oncoprotein in an inducible manner ...with E7 expression plasmids under the control of a ... See full document
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Predicting response to radical (chemo)radiotherapy with circulating HPV DNA in locally advanced head and neck squamous carcinoma.
... biopsies: HPV16 detection in ...of E7 expression using methods and primers described previously (Lamarcq et al, 2002) in a 7500 Sequence detection system (Applied Biosystems, Foster City, CA, USA/Thermo ... See full document
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Human Papillomavirus E7 Oncoprotein Increases Production of the Anti-Inflammatory Interleukin-18 Binding Protein in Keratinocytes
... of E7 were also tested for their ability to augment IL-18BP ...on E7 structure, since CR3 has been shown to be highly structured (30, ...for E7 proteins ...of E7 are necessary for this ... See full document
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