[PDF] Top 20 A NOVEL OPHTHALMIC DRUG DELIVERY SYSTEM: IN SITU GEL

... for drug content (by UV Spectrophotometer), clarity, pH, sol-gel transition, rheology, in-vitro drug release and sterility 41 ...CONCLUSIONS: Ophthalmic drug delivery ... See full document

... the novel techniques for ophthalmic drug ...the novel deli- very system, various approaches and carriers are used like in situ gelling, ophthalmic inserts, nanoparticles, ... See full document

... Ophthalmic strips are individually packed hence are sterile until time of use, and are made up of filter paper. They are used in detecting corneal abrasions and diagnosing Dry eye syndrome. These strips can be ... See full document

... In situ forming polymeric formulations are drug delivery systems that are in sol form before administration in the nasal cavity, but once administered, undergo gelation in situ, to form a ... See full document

... conventional ophthalmic delivery system drawbacks can be overcome by the use of in-situ gelling ...gelling system have been developed to prolong the precorneal residence time of a ...to ... See full document

... of gel-forming polymers such as sodium alginate and gellan gum and also calcium carbonate and trisodium ...in situ released calcium ion from calcium citrate complex gets entrapped in polymeric chains ... See full document

... in situ gel as gastroretentive drug delivery system represents a revolution in oral controlled release dosage forms in comparison with conventional oral liquids, as it prolongs the ... See full document

... ‘in situ gel’ system has emerged as one of the best novel drug delivery systems, the in situ gelling system helps for the sustained and controlled release of the ... See full document

... in situ gel (Gels A, B, and C) with different ...the drug was released within 2 h. In contrast, release of BLZ from in situ gels in TF solution occurred after more than 12 h due to the ... See full document

... floating drug delivery systems are normally prepared from gel-forming or highly swellable polysaccharides or matrix forming polymers like poly acrylate, polycarbonate, polystyrene and poly ...of ... See full document

... The eye drops have very poor bioavailability due to their rapid washout during lachrymation in eyes. Most of the systems are applied as solution or suspension. The rapid pre-corneal elimination observed with conventional ... See full document

... nervous system and brain ...of drug candidates, proteins, immunogenic substances and also to ...targeted drug delivery systems for ophthalmic, diabetic and also for anticancer ... See full document

... ocular drug delivery system as they are simple to prepare but the main problem associated with liposomes is there stability (due to hydrolysis of phospholipids), there limited drug loading ... See full document

... These are stable dispersions of water and oil, consisting of a mixture of surfactant and co-surfactant in a manner to reduce interfacial tension. These have been found to increase the ocular bioavailability of ... See full document

... of ophthalmic solutions caused by dilution and drainage from the eye can be overcome by using in situ forming ophthalmic drug delivery system prepared from polymer that exhibit ... See full document

... CONCLUSION: Drug delivery to ocular mucosa for the treatment of ocular disease is associated with many ...applied drug penetrates the cornea and reaches intraocular ...in situ gels. The ... See full document

... ayurvedic system of Indian medicine and is called “Nasya Karma”. Drug delivery through the nose is uncomplicated and convenient and can include the delivery of solutions, suspensions, powders, ... See full document

... ocular delivery the physiological constraints imposed by the protective mechanisms of the eye lead to low absorption of drugs, resulting in a short duration of the therapeutic ...in situ gelling systems, ... See full document

... the drug release and the apparent disappearance rate constant of drug also ...the drug. Maximum loading of drug was seen in 25% ethanolic ...in situ nasal gel of salbutamol ... See full document

... of gel formation at the site of application after the composition or formulation has been applied to the ...a drug delivery agent, the in-situ gel has an advantage related to the ... See full document