Top PDF O Methyl N phenyl­thio­carbamate

O Methyl N phenyl­thio­carbamate

O Methyl N phenyl­thio­carbamate

Neutral and deprotonated molecules related to the potentially polydentate title compound, MeOC( S)N(H)Ph, (I), are known to coordinate metal centres in a variety of coordination modes involving combinations of the S, O and N atoms. The structure of MeOC( S)N(H)Ph (Fig. 1 and Table 1) was determined in order to provide data to allow comparisons with the coordinated forms of the ligand. The deviation of the central atoms S, O, N and C1 from their least-squares plane are 0.0002 (3), 0.0019 (8), 0.0028 (10) and ÿ0.0117 (12) AÊ, respectively. This planarity does not extend to include the phenyl group, as seen by the C1ÐN1ÐC2ÐC3 torsion angle of ÿ60.13 (18) . The CÐS, C1ÐO and C1ÐN bond distances
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Methyl N [(2 hy­droxy­naphthalen 1 yl)(phen­yl)meth­yl]carbamate

Methyl N [(2 hy­droxy­naphthalen 1 yl)(phen­yl)meth­yl]carbamate

As can be seen from the packing diagram (Fig. 2), the intermolecular O—H O hydrogen bonds (Table 1) link the molecules, to form infinite chains along the c axis. The inter- molecular O—H O and intramolecular N—H O hydrogen bonds seem to be effective in the stabilization of the crystal structure. Dipole–dipole and van der Waals interactions are effective in the molecular packing.

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Synthesis and biological screening of 5-{[(4,6-disubstituted pyrimidine-2-yl)thio]methyl}-N-phenyl-1,3,4-thiadiazol-2-amines

Synthesis and biological screening of 5-{[(4,6-disubstituted pyrimidine-2-yl)thio]methyl}-N-phenyl-1,3,4-thiadiazol-2-amines

Varian EM 390 MHz spectrometer using TMS as internal standard. Mass spectra were recorded on Shimadzu 2010A LC-MS system. The reactions were monitored by thin layer chromatography using silica gel plates and detected by UV chamber and iodine as visualizing agent. The purity of the compounds was checked on silica gel precoated plates. All the solvents used were purifi ed according to the standard methods 16 . Phenyl isothiocyanate was prepared

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Two isostructural carbamates: the o tolyl N (pyridin 3 yl)carbamate and 2 bromo­phenyl N (pyridin 3 yl)carbamate monohydrates

Two isostructural carbamates: the o tolyl N (pyridin 3 yl)carbamate and 2 bromo­phenyl N (pyridin 3 yl)carbamate monohydrates

fashion to the Schotten–Baumann reaction and can provide relatively pure products in high yields. However, when using 2-aminopyridines, additional double carbamates are formed where both of the N—H H atoms are replaced by formates. In order to minimize double carbamate formation for these derivatives, reactions are usually performed by mixing the reagents without solvent and base at lower temperature, followed by simple recrystallization.

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Copolymerization of Methyl Acrylate with N 4 Methyl phenyl maleimide and characterization of the polymers

Copolymerization of Methyl Acrylate with N 4 Methyl phenyl maleimide and characterization of the polymers

after the cyclodehydration of acid into imide give compound 4 N-(4-Methyl-phenyl) maleimide. Synthesis of this compound is conformed of disappear of both carboxylic acid and NH band in IR region and we get two new band 1770, 1709due to synthesis of C=O functional group. Compound N-(4-Methyl-phenyl) maleimide was reflux at 48 hr. in the present of AIBN in THF solvent gave homopolymer 5. It shows C-C at 1170 cm -1 IR and δ 2.4 CH 3 of (–CH–CH–) n in 1

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tert Butyl N benzyl N (4 methyl 2 pyrid­yl)carbamate

tert Butyl N benzyl N (4 methyl 2 pyrid­yl)carbamate

In the crystal structure of the title compound I the pyridine ring makes dihedral angles of 83.71 (6)° and 9.2 (1)° to the phenyl ring and the carbamate plane, respectively. The phenyl ring and the carbamate plane are nearly perpendicular to one another with a dihedral angle of 87.17 (7)°. The N1—C2 bond [1.383 (2) Å] of the carbamte function is shorter than the normal N1—C16-bond [1.475 (2) Å] to the benzyl moiety, indicating the partial double bond character of the amide bond of the carbamate.

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9 (Thio 2′ methyl 4′ nitro­phenyl) acridine

9 (Thio 2′ methyl 4′ nitro­phenyl) acridine

Ngadi, L., Bsiri, N., Mahamoud, A., Galy, A. M., Galy, J. P., Soyfer, J. C., Barbe, J., Placidi, M., Rodriguez-Santiago, J. J., Mesa-Valle, C., Lombardo, R. Mascaro, C. & Osuna, A. (1993). Arzneim. Forsch. Drug. Res. 43, 480. Sheldrick, G. M. (1990a). Acta Cryst. A46, 467±473.

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Methyl N [4 (4,6 di­methyl­pyrimidin 2 ylamino)thio­carbon­yl]carbamate

Methyl N [4 (4,6 di­methyl­pyrimidin 2 ylamino)thio­carbon­yl]carbamate

ring and a thiourea carboxylic acid methyl ester, possesses mirror symmetry and an intramolecular N—H N hydrogen bond. In the crystal structure, N—H S hydrogen bonds link symmetry-related molecules to form dimers, which in turn are linked by a C—H O hydogen bond to form a two- dimensional planar structure.

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Synthesis of lanthanon complexes with βββdiketones and study of their spectral and electrochemical behavior

Synthesis of lanthanon complexes with βββdiketones and study of their spectral and electrochemical behavior

The ligand PMAP was prepared from 1 − phenyl − 3 − methyl pyrazolone − 5 and acetyl chloride using a modified Jensen procedure (1) . Into a one litre−3−necked flask containing dioxane (100 ml) carrying a dropping funnel, a mechanical stirrer and a reflux condenser was placed (17.0 g). A solution was obtained by gentle heating and stirring calcium hydroxide (10g) was added and acetyl chloride (15ml) was added drop wise with in about 2−3 minutes. The reaction was exothermic and the reaction mixture became a paste. The mixture was allowed to cool and then refluxed with stirring for one hour on a heating mantle, during which period the bright yellow complex formed initially turned yellowish brown. The complex was decomposed by pouring the reaction mixture into stirred hydrochloric acid (500 ml − 3N). A yellowish off solid settled and was filtered 95% ethanol recrystallised twice from white crystals m.pt. 112°C (C 12 H 12 N 2 O 2 ). Its
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Cytotoxic and antitumour studies of acetoacetanilide N(4)-methyl(phenyl)thiosemicarbazone and its transition Metal Complexes

Cytotoxic and antitumour studies of acetoacetanilide N(4)-methyl(phenyl)thiosemicarbazone and its transition Metal Complexes

Bearing in mind that the N-N-S or O-N-O or O-N-S donor system is a common feature for all compounds with carcinostatic potency, we proceeded the antitumour studies of acetoacetanilide N(4)-methyl(phenyl)thiosemicarbazone and its metal complexes and we got promising results. In vitro cytotoxicity studies on AcTSC and its different complexes showed cytotoxicity against DLA cell lines. The copper complex showed maximum cytotoxicity with an IC 50 value of 46 µg/ml.

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Methyl 3 di­methyl­amino 2 {2 [2 (di­methyl­amino) 1 (3 phenyl 1,2,4 oxa­diazol 5 yl)­vinyl­­oxy]­phenyl}acryl­ate

Methyl 3 di­methyl­amino 2 {2 [2 (di­methyl­amino) 1 (3 phenyl 1,2,4 oxa­diazol 5 yl)­vinyl­­oxy]­phenyl}acryl­ate

We report here the crystal structure of the title compound, (I), synthesized from methyl {2-[(3-phenyl-1,2,4-oxadiazol-5- yl)methoxy]phenyl}acetate (Wang et al., 2004) and N,N-di- methylformamide dimethyl acetal. The molecular structure of (I) is shown in Fig. 1 and bond lengths and angles are detailed in Table 1. The crystal packing is stabilized mainly by van der Waals interactions, though there are short intra- and inter- molecular CÐH O contacts (Fig. 2 and Table 2).

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Methyl N (di­meth­­oxy­phosphor­yl)carbamate

Methyl N (di­meth­­oxy­phosphor­yl)carbamate

atom has a slightly distorted tetrahedral configuration. The mixed imide moiety can be described as cisoid–transoid in which the two opposing dipoles (P O and C O) are oriented with a O C P O torsion angle of 150.88(18) . In the crystal, molecules are linked by pairs of N—H O hydrogen bonds, forming inversion dimers.

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Ethyl 5 eth­oxy­methyl­ene 2 methyl 6 oxo 4 phenyl 1,4,5,6 tetra­hydro­pyridine 3 carboxyl­ate

Ethyl 5 eth­oxy­methyl­ene 2 methyl 6 oxo 4 phenyl 1,4,5,6 tetra­hydro­pyridine 3 carboxyl­ate

The 2(1H)-pyridone ring of (I) has a screw–boat conformation, with puckering parameters (Cremer & Pople, 1975) Q = 0.280 (2) Å, θ = 109.5 (4)° and φ = 339.1 (5)°, with the axis through C2—C3, for N1—C1—C2—C3—C4—C5—C6. The dihedral angle between the least-squares planes of the phenyl ring and the pyridone moiety is 86.0 (1)°. The mean Csp 2 —Csp 2 bond length within this ring is 1.434 (1) Å. An N—H···O hydrogen bond holds the molecules together in a

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Methyl 3,4 O di­benzoyl 2 O benzyl 1 thio β L fuco­pyran­oside

Methyl 3,4 O di­benzoyl 2 O benzyl 1 thio β L fuco­pyran­oside

configuration for (2) was assigned assuming unmodified configura- tions for the chiral centres of (1). The absolute configuration deter- mined with low precision from anomalous scattering effects is in accord with the known configuration of the starting material (Jain & Matta, 1990). The peripheral C atoms in phenyl ring C9—C14 exhibit high anisotropic displacement parameters.

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Phenyl 2 amino N,6 O di­benzyl 2,3 N,O carbonyl 2 de­­oxy 1 thio β D gluco­pyran­oside

Phenyl 2 amino N,6 O di­benzyl 2,3 N,O carbonyl 2 de­­oxy 1 thio β D gluco­pyran­oside

conformation of the pyranose ring. The phenyl group attached to the S atom and the benzyl group bonding to the N atom are each disordered over two positions with site occupancies of 0.624 (3):0.376 (3) and 0.526 (3):0.474 (3), respectively. An intermolecular O—H O hydrogen bond is observed.

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Crystal structures of 4 chloro­phenyl N (3,5 di­nitro­phen­yl)carbamate and phenyl N (3,5 di­nitro­phen­yl)carbamate

Crystal structures of 4 chloro­phenyl N (3,5 di­nitro­phen­yl)carbamate and phenyl N (3,5 di­nitro­phen­yl)carbamate

compounds, molecules are linked via N—H O hydrogen bonds, forming chains propagating along [010]. In (I), C—H O hydrogen bonds also link molecules within the chains. The crystal packing in (I) also features a very weak – interaction [centroid–centroid distance = 3.7519 (9) A ˚ ].

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Methyl N hy­dr­oxy N (2 methyl­phen­yl)carbamate

Methyl N hy­dr­oxy N (2 methyl­phen­yl)carbamate

products and biologically active compounds. The title compound, which was readily synthesized from (N)-(2-methyl- phenyl)hydroxylamine, act as an intermediate for the synthesis of Strobilurin fungicide Pyraclostrobin. In this article, the crystal structure of the title compound methyl(N)-hydroxy-2- methylphenylcarbamate is described (Fig. 1). There are three independent molecules in the asymmetric unit, which are connected by intermolecular O—H···O hydrogen bonds to construct a large ring involving 15 atoms with graph set notation R 3

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(E) O Methyl N (4 methyl­phen­yl)thio­carbamate

(E) O Methyl N (4 methyl­phen­yl)thio­carbamate

The title compound was prepared by refluxing 4-methylphenyl isothiocyanate (Aldrich) with methanol according to a literature procedure (Ho et al., 2005). The white precipitate which was obtained upon concentration of the reaction solution was dissolved in hot dichloromethane and layered with hot hexane which, upon cooling, resulted in the formation of colorless crystals (m.p. 354–356 K). Analysis found: C 59.61, H 5.84, N 7.80, S 16.83%; C 9 H 11 NOS

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Evaluation of Neuroprotective Potential of Some Newly Synthesized Benzopyran-2-One Derivatives in Swiss Albino Mice

Evaluation of Neuroprotective Potential of Some Newly Synthesized Benzopyran-2-One Derivatives in Swiss Albino Mice

Background: Present study was carried out to evaluate neuroprotective activity of newly synthesized Benzopyran-2-one derivatives. Methods: Three compounds namely 7-(2-(o-furan)-phenyl thiazolidinyl)-4-methyl benzopyran-2-one (FPTMB), 7-(2-(N,N dimethyl)-phenyl thiazolidinyl)-4-methyl-benzopyran-2-one (DPTMB) and 7-(2-(p-hydroxy)- phenyl thiazolidinyl)-4-methyl-benzopyran-2-one (HPTMB) were assessed for their effects on Central Nervous System (CNS) using a series of established pharmacological tests including evasion test for anxiolytic activity, actophotometer test for spontaneous motor activity (SMA), rotarod test for skeletal muscle relaxation and pentylenetetrazole (PTZ) induced convulsant model for anti-convulsant activity followed by Eddy’s hot plate and Haffner’s tail clip method for analgesic activity. Results: These derivatives were found to produce symptoms of CNS depression in conscious mice, viz. significant reduction in SMA and exploratory behavior by evasion test and skeletal muscle relaxation and showed a significant prolongation of latency and reduced duration of convulsions induced by PTZ. Further, these test compounds failed to show a significant anti-nociceptive activity evaluated by centrally acting analgesic models i.e., Eddy’s hot plate and Haffner’s tail clip methods. Conclusion: It may be concluded that all three derivatives possess anxiolytic activity, SMA, skeletal muscle relaxation and anti-convulsant activity but do not possess analgesic activity.
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Crystal structure of phenyl N (3,5 di­methyl­phenyl)carbamate

Crystal structure of phenyl N (3,5 di­methyl­phenyl)carbamate

independent molecules (A and B). The dimethylphenyl ring, the phenyl ring and the central carbamate N—C( O)—O group are not coplanar. In molecule A, the dimethylphenyl and phenyl rings are inclined to the carbamate group mean plane by 27.71 (13) and 71.70 (4) , respectively, and to one another by

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