[PDF] Top 20 Ocular inserts: Novel approach for drug delivery into eyes

... a drug delivery point of view. Ophthalmic drug delivery is extremely interesting and highly challenging ...many novel formulations have been developed. Ocular insert is one of ... See full document

... the ocular dosage forms, the physiological and anatomical constraints put forth by the eye is a significant challenge to the pharmaceutical scientists and researchers to target drugs to the posterior segment of ... See full document

... Ocular implants are gaining much of importance in the ophthalmic drug delivery and it is proving to be a dynamic area of interest in ...the drug at pre- determined rate without interference ... See full document

... Refraction of the light rays: The light rays from the object pass through the conjunctiva, cornea, aqueous humor, lens and vitreous humor in that order. All these structures refract the light such that it falls on the ... See full document

... in ocular delivery for various drug ...to, ocular surfaces, and release contents at optimal rates ...precorneal drug retention and drug bioavailability ...This approach ... See full document

... of drug administration to treat posterior ocular ...transscleral drug delivery with periocular administration route is evolved as an alternative mode of drug delivery to the ... See full document

... the novel classes of drug delivery systems, ocular inserts, are gaining worldwide popularity, release drugs at a pre- programmed rate for extended period by increasing the precorneal ... See full document

... The cornea is covered by a thin epithelial layer continuous with the conjunctiva at the cornea- sclerotic junction. The main bulk of cornea is formed of criss-crossing layers of collagen and is bounded by elastic lamina ... See full document

... multiparticulate drug delivery system for ...the drug released in divided doses over timed intervals throughout the day to produce a pulsatile blood concentration curve with ...of drug and ... See full document

... floating drug delivery system (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric ...of novel delivery systems which ... See full document

... contain drug substances which are used in ocular drug ...The drug substance must be active on surface of eye or internal region of eye after passage through cornea or ...and ocular ... See full document

... of drug, are very significant in improving the bioavailability of drug, increasing the solubility, decreasing the stimulation, and masking the ...of novel cyclodextrin based ...the drug ... See full document

... Transdermal drug delivery system was first introduced more than 20 years ...transdermal drug delivery system merged into larger ...Transdermal drug delivery system is a type of ... See full document

... Mucoadhesive Drug Delivery Mucoadhesive drug delivery systems are being discovered for the localization of the active component to a specific ... See full document

... The only prodrug that is used clinically for entering the brain predominantly through LAT1-mediated transport is L-dopa. The neurotransmitter dopamine is not able to cross the BBB due to its hydrophilic nature. However, ... See full document

... Since ultradeformable vesicles have the capability of delivering the large molecules, they can be used to deliver vaccines topically. Transferosomes containing proteins like integral membrane protein, human serum ... See full document

... The drug should possess following criteria’s to be designed as sublingual tablet are lipophilic (pKa > 2 for acidic drug and 10 < for basic drug, Log p is ...Many drug properties could ... See full document

... new delivery systems which can enhance the rate and the extent of solubilization into aqueous intestinal fluids and the capacity to cross ...based drug delivery system have been found promising for ... See full document

... base novel drug delivery systems, in order to modify and control the release behavior of the ...entrapped drug compound from physical and environmental ... See full document

... of drug-loaded nanoparticles for prolonged ocular ...of drug-encapsulated chitosan-montmorillonite/TPP nanoparticles (CS-MMT/TPP ...sustained drug release was observed with the BH-loaded ... See full document