[PDF] Top 20 Off-label drugs use in pediatric palliative care

... of drugs is off-label in the overwhelming majority of cases, for indication use and/or for age and/or modality of administration and/or formulation ... See full document

... laryngitis. Drugs with lower dosage than specified involved mainly cold preparations (n = 24); ibuprofen (n = 20); helicidine, a cough suppressant (n = 19); and rifamycin for topical use (n = 17), whereas ... See full document

... identify off-label drugs. Each off-label drug event was categorized into different groups: unapproved Indication (which includes unlicensed drug and utilization of contraindicated ... See full document

... of drugs of questionable use, such as multivitamins and domperidone, as reported in a previous study ...prolonged use of drugs containing the same ...OL use and UL obtained in different ... See full document

... involved pediatric hospital wards, seven neonatal hospital wards, and twelve the commu- nity ...The off-label and unlicensed classification methods varied, making the results difficult to ...general, ... See full document

... mum care to their patients, to explain to them the individual health risks discovered, and to explain risks and benefits of any needed ...treatment, off- label prescribing may offer benefits unique ... See full document

... intensive care unit to the MCU during ...prescriptions, drugs were either unlicensed (1024; 48%) or off-label (390; ...unlicensed drugs or off-label ...were ... See full document

... of off-label drug use have not been harmonized across the ...concerning off-label drug use have been established, and ra- tional off-label drug use is ... See full document

... of drugs prescribed have not been tested in children and safety and efficacy of children‘s medicines are frequently supported by low quality of ...an off- label or unlicensed basis. The ... See full document

... prescribe drugs that match individual patient needs regardless of label, but they face difficulties staying abreast of rapidly evolving ...using off-label drugs (actually only 17% ... See full document

... any off-label ...one off-label drug which is similar to the frequency of off-label use in patients with adverse drug ...of off-label drug was more among ... See full document

... Palliative care is an approach that improves the quality of life of patients and their families facing the problem associated with life-threatening illness, through the prevention and relief of suffering by ... See full document

... the drugs used in treating their children’s chronic renal disease at two German university hospital outpatient care ...the off-label use of ...of off-label use was ... See full document

... intensive care unit (NICU) is 6% so- dium chloride, an oral sodium supplement made at the Royal Children’s Hospital, ...registered pediatric preparation of spironolactone is available in ...licensed ... See full document

... drug’s label or other data available to the prescriber. The off-label use of a drug should be based on sound scientific evidence, expert medi- cal judgment, or published ...in pediatric ... See full document

... the label has not been approved by the ...the pediatric population has not been submitted to FDA for review or has not met the regulatory standards of “ substantial evidence ” for FDA ap- ...of ... See full document

... some off-label uses are often supported by medical literature, or by clinical ...about off-label uses in the high-benefit situations, while discouraging and informing physicians and patients ... See full document

... providing care that addresses need, improves well-being, and relieves suffering without seeking to resolve the underlying ...health care system. Doctors who are providing care in these situations ... See full document

... of care, and improve affordability (White House, ...health care organizations are seeking solutions that will help them reinvent ...health care to align with the PPACA objectives. While ... See full document

... Keywords: resuscitation plan, advance care plan, pediatric palliative care, shared decision making 29.. 30.[r] ... See full document