[PDF] Top 20 On DNA methylation: an introductory review
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On DNA methylation: an introductory review
... mals, cytosines, whose downstream neighbour is guanine, are particularly a common target for methylation. This cytosine joined with guanine by phosphate is termed CpG dinucleotide. A stretch of over hundred ... See full document
7
DNA methylation changes of whole blood cells in response to active smoking exposure in adults: a systematic review of DNA methylation studies
... full-text review, of which one therapy-related study was ...blood DNA methylation were eligible for this sys- tematic review, including 14 EWASs [5, 6, 11–22] and 3 GSMSs [7, 8, 23] which were ... See full document
10
DNA Methylation Validation Methods: a Coherent Review with Practical Comparison
... For MS-HRM analysis, the only requirement are primers surrounding the region with CpGs of interest. It is again crucial to obtain a pure PCR product. Primers should be between 15 and 30 bp long with similar melting ... See full document
11
Review of the development of DNA methylation as a marker of response to neoadjuvant therapy and outcomes in rectal cancer
... non-coding DNA repeat se- quence was associated with worse survival (hazard ratio ...global methylation in this ...double-stranded DNA breaks which contribute to genetic ...promoter ... See full document
9
New Frontiers in Melanoma Epigenetics—The More We Know, the More We Don’t Know
... this review several ...with DNA methylation or demethylation, and a few more drugs that cause histone acetylation or deacetylation have been already studied even in preclinical or early clinical ... See full document
23
Review Article Diagnostic value of circulating methylated SEPT9 DNA in colorectal cancer: a meta-analysis
... that DNA methylation is an important manner of regulation at the epigenetic level for gene ex- pression, cell growth, and cell differentiation ...that DNA methylation of different genes was ... See full document
11
DNA methylation and DNA methyltransferases
... genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the num- ber of protein-encoding mammalian genes was ... See full document
10
Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies
... The lack of consistency within the published data could be related to the considerable heterogeneity across the studies in several aspects of study design, laboratory methods and statistical analyses. All studies ... See full document
10
Non-coding RNA-linked epigenetic regulation in cardiac hypertrophy
... as DNA methylation, histone modification, and oxidative modification of nucleic acid, could lead to changes in chromosome structure and cardiac ...this review, we summarize the current information on ... See full document
9
Review Article Genetic and epigenetic alterations during renal carcino- genesis
... regional DNA hypermethylation on C-type CpG islands has already accu- mulated in such non-cancerous renal tissues, suggesting that, from the viewpoint of altered DNA methylation, the presence of ... See full document
16
DNA methylation and cognitive aging
... that DNA methylation, one of major epigenetic mechanisms, plays a pivotal role in the pathogenesis of age-related neurodegenerations and cognitive ...this review, the evolving knowledge of ... See full document
11
Epigenetic Regulation Mediated by Methylation in the Pathogenesis and Precision Medicine of Rheumatoid Arthritis
... especially DNA methylation and histone modification. DNA methylation and histone methylation are involved in innate and adoptive immune cell differentiation and the migration, ... See full document
15
DNA Methylation in Colorectal Cancer: A brief Review
... DNA methylation is a heritable epigenetic mark involved in the covalent transfer of a methyl group to the C-5' position of the cytosine ring of DNA by enzymes called DNA methyltransferases ... See full document
7
DNA methylation links genetics, fetal environment, and an unhealthy lifestyle to the development of type 2 diabetes
... includes DNA methylation, histone modifications, and non-coding RNA. DNA methylation is the most studied epigenetic mark so far and occurs mainly at the fifth position of the cytosine ring in ... See full document
8
DNA methylation, epialleles and gene regulation: Insights from the honey bee
... establishing DNA methylation patterns, although the exact nature of this role remains unclear (Wojciechowski et ...no DNA methylation toolkit and does not require demethylation of genomic ... See full document
176
Epigenomic analysis of lung adenocarcinoma reveals novel DNA methylation patterns associated with smoking
... We used the proper signature selection method, which combines the nearest centroid and genetic algorithm fitting tuning approach, to search for the best DNA methylation loci as diagnostic markers. Genetic ... See full document
9
Genome-wide screening of DNA methylation in bovine blastocysts with different kinetics of development
... includes DNA methylation patterns, in this study we compared the global DNA methylation profile of embryos with different kinetics of development in order to identify general pathways and ... See full document
13
Dynamic changes in global and gene specific DNA methylation during hibernation in adult thirteen lined ground squirrels, Ictidomys tridecemlineatus
... in DNA by methylation. DNA methylation is well known to be a mechanism that confers upon DNA its cellular identity during differentiation in response to innate developmental ...that ... See full document
9
Epigenetics mechanisms and degenerative diseases
... of DNA required and lowest detection limit for detecting the difference in methylation status is ...of DNA is 20 ...detecting methylation status of region of interest when the small amount of ... See full document
11
Insertion of Foreign DNA into an Established Mammalian Genome Can Alter the Methylation of Cellular DNA Sequences
... Since methylation at 59-CG-39 sites in the 900 hap- loid IAP copies in hamster cells is expected to be polymorphic, a control analysis was ...of methylation in this seg- ...59-CG-39 methylation in ... See full document
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