[PDF] Top 20 Oncogenic mutations of thyroid hormone receptor β
Has 10000 "Oncogenic mutations of thyroid hormone receptor β" found on our website. Below are the top 20 most common "Oncogenic mutations of thyroid hormone receptor β".
Oncogenic mutations of thyroid hormone receptor β
... the thyroid hormone receptor TRβ1, PV, functions as an ...the oncogenic activity of mutated TRβ1 is uniquely dependent on the PV mutated ...the oncogenic actions of TRβ1 ...the ... See full document
17
Divergent roles for thyroid hormone receptor β isoforms in the endocrine axis and auditory system
... hypothalamus (PVN) (9). Our model now provides an important resource with which to analyze the role of TRβ2 in the regulation of TRH expression in the PVN over a wide range of thyroid hormone ... See full document
11
Thyroid hormone action in the absence of thyroid hormone receptor DNA binding in vivo
... The linearized targeting constructs were electropo- rated into 129 ES cells, and G418 neomycin-resistant colonies were isolated and expanded. ES cells electro- porated with the targeting vector were screened by Southern ... See full document
11
Mechanisms of thyroid hormone action
... point mutations in TRα that resulted in receptors with dominant-negative properties have been reported (67, ...TRβ mutations and provide very strong support to the results of genetic and pharmacologic ... See full document
10
An intronic SNP in the thyroid hormone receptor β gene is associated with pituitary cell specific over expression of a mutant thyroid hormone receptor β2 (R338W) in the index case of pituitary selective resistance to thyroid hormone
... Background: The syndrome of resistance to thyroid hormone (RTH) is caused by mutations in the thyroid hormone receptor b gene ( THRB ). The syndrome varies from asymptomatic to ... See full document
7
Original Article Expression of thyroid hormone responsive spot 14 homolog and thyroid hormone receptor β1 in human breast cancer tissues and its clinical significance
... receptor beta (THRB) gene on chromosome 3 [13]. Currently, the most studied is TRβ1 sub- type. Most researchers believe that TRβ1 may act as a tumor suppressor gene in the occur- rence and development of human ... See full document
8
Genetic analysis of 29 kindreds with generalized and pituitary resistance to thyroid hormone Identification of thirteen novel mutations in the thyroid hormone receptor beta gene
... the thyroid hormone receptor beta gene, except for a single case of a seven nucleotide ...the hormone- binding domain of the ...different mutations, and haplotype analyses of the mutant ... See full document
11
Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone β receptor inhibits mitotic progression
... T3-dependent, TRβ1-mediated destabilization of PTTG1 occurs via the proteasomal degradation machinery. We have previously shown that the T3-induced degradation of TRβ1 is mediated by the protea- some degradation pathway ... See full document
14
Thyroid hormone–sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform–specific
... for thyroid hormone. We used the thyroid hor- mone receptor-β–selective (TR-β–selective) ligand, GC-1, to determine by a pharmacological approach whether adaptive thermogenesis ... See full document
10
Thyroid hormone resistance syndrome Inhibition of normal receptor function by mutant thyroid hormone receptors
... these receptor mutants, one containing a Gly to Arg change at amino acid 340 (G340R) and the other a Pro to His change at amino acid 448 ...the mutations that occur in the T3 resistance syndrome. None of ... See full document
9
Screening of nineteen unrelated families with generalized resistance to thyroid hormone for known point mutations in the thyroid hormone receptor beta gene and the detection of a new mutation
... to thyroid hormone (GRTH) is a syndrome characterized by impaired tissue responsiveness to thyroid ...point mutations in the hormone binding domain of the thyroid hormone ... See full document
8
Mutations of CpG dinucleotides located in the triiodothyronine (T3) binding domain of the thyroid hormone receptor (TR) beta gene that appears to be devoid of natural mutations may not be detected because they are unlikely to produce the clinical phenotype of resistance to thyroid hormone
... the thyroid hormone receptor (TR) beta gene that appears to be devoid of natural mutations may not be detected because they are unlikely to produce the clinical phenotype of resistance to ... See full document
10
A clinician’s guide to understanding resistance to thyroid hormone due to receptor mutations in the TRα and TRβ isoforms
... of thyroid hor- mone action such as serum SGOT, SGPT, cholesterol, triglycerides, ferritin, osteocalcin, creatine phosphoki- nase (CPK), and sex hormone binding globulin (SHBG), also can be helpful in ... See full document
11
Food restriction in young Japanese quails: effects on growth, metabolism, plasma thyroid hormones and mRNA species in the thyroid hormone signalling pathway
... of thyroid hormone receptors (TRs), and several T3-mediated effects are regulated through the role of TRs as hormone inducible transcription factors for their target genes (Yen, ...these ... See full document
8
Identical mutations in unrelated families with generalized resistance to thyroid hormone occur in cytosine guanine rich areas of the thyroid hormone receptor beta gene Analysis of 15 families
... to thyroid hormone (GRTH) is a syndrome of variable reduction of tissue responsiveness to thyroid ...point mutations in the human thyroid hormone receptor beta (TR beta) ... See full document
9
microRNA and thyroid hormone signaling in cardiac and skeletal muscle
... estrogen-related receptor γ (ERRγ), which mediates the effect of peroxi- some proliferators-activated receptors β/δ and PPARα on energy metabolism and skeletal muscle fiber specific- ity [63, ...hypo- ... See full document
8
Effect of thyroid statuses on sodium/iodide symporter (NIS) gene expression in the extrathyroidal tissues in mice
... different thyroid statuses using Northern blot and ...in thyroid but not in stomach (Figure ...in thyroid, qPCR was performed and statistically significant differ- ences among control, hyperthyroid, ... See full document
6
MONOCLONAL ANTIBODY: A MOLECULAR TARGETED THERAPIES FOR CANCER TREATMENT
... the receptor), for example bevacizumab on vascular endothelial growth factor (VEGF), or the cell surface receptors themselves, for instance cetuximab on ... See full document
16
Development of Thyroid Associated Ophthalmopathy in Patients Who Underwent Total Thyroidectomy
... for thyroid diseases other than GD, and the pathogenesis of TAO in these other thyroid diseases is ...However, thyroid hormonal function and TSH recep- tor antibody tests, which were conducted in ... See full document
6
A heartfelt response: new thyroid hormone–sensitive neurons in the hypothalamus
... THRA mutations result in hypothyroid-like defects, with mental and physical retardation but with only marginal abnormalities in serum thyroid hormone levels (8, ...THRB mutations result in ... See full document
5
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