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[PDF] Top 20 Original Article The effect and mechanism of UCH-L1 inhibitor LDN-57444 on hypoxic/ischemic injury in neonatal rats

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Original Article The effect and mechanism of UCH-L1 inhibitor LDN-57444 on hypoxic/ischemic injury in neonatal rats

Original Article The effect and mechanism of UCH-L1 inhibitor LDN-57444 on hypoxic/ischemic injury in neonatal rats

... of UCH-L1 is to stabilize the ubiquitin monomer [13] and inhibit its degrada- tion ...that UCH-L1 can closely interact with the cytoskeletal proteins, and play important roles in the axonal ... See full document

7

Original Article Effect of hyperbaric oxygen on neurological recovery of neonatal rats following hypoxic-ischemic brain damage and its underlying mechanism

Original Article Effect of hyperbaric oxygen on neurological recovery of neonatal rats following hypoxic-ischemic brain damage and its underlying mechanism

... brain injury, there are two opinions ...system injury, the endogenous NSCs are induced to differentiate into repair functional cells to repair the brain injury ...cellular injury and recovery ... See full document

10

Neuroinflammation and MMPs: potential therapeutic targets in neonatal hypoxic-ischemic injury

Neuroinflammation and MMPs: potential therapeutic targets in neonatal hypoxic-ischemic injury

... In addition to their roles in activating cytokines and processing basement membrane proteins, MMPs are effi- cient at cleaving lecticans [39]. Lectican proteoglycans are upregulated in glial scars [6], where their ... See full document

7

Original Article Gene expression profiling and identification of key genes involved in neonatal hypoxic-ischemic brain injury

Original Article Gene expression profiling and identification of key genes involved in neonatal hypoxic-ischemic brain injury

... brain injury by its participation in distinct events such as neovascularization, neuropro- tection and the apoptotic process ...the neonatal brain and CYGB might exhibit neuroprotective effects possibly by ... See full document

10

Original Article Effects of mannitol on hypoxic-ischemic brain edema and aquaporin-4 expression in neonatal rats

Original Article Effects of mannitol on hypoxic-ischemic brain edema and aquaporin-4 expression in neonatal rats

... Brain edema is a vital characteristic in the pathophysiological progress of hypoxic-isch- emic brain damage (HIBD). Igor Klatzo classi- fied brain edema into cytotoxic edema and vasogenic edema according to ... See full document

5

Ceftriaxone attenuates hypoxic-ischemic brain injury in neonatal rats

Ceftriaxone attenuates hypoxic-ischemic brain injury in neonatal rats

... In our studies, GLT1 protein expression in the whole brain lysate of P7 rat did not change after ceftriaxone treatment. But, immunohistochemical study showed that pre-treatment with ceftriaxone induced GLT1 protein ... See full document

10

Original Article Neuroprotective and regenerative effects of melatonin on hypoxic-ischemic brain injury in neonatal rats

Original Article Neuroprotective and regenerative effects of melatonin on hypoxic-ischemic brain injury in neonatal rats

... anti-apoptotic effect of melatonin was mainly due to its inhibi- tion of mitochondrial calcium overload and depolarization of the mitochondrial membrane, which decreased membrane permeability ...The ... See full document

9

Original Article ER stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy

Original Article ER stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy

... of neonatal hypoxic-ischemic encephalopathy (HIE) injury are correlated with disease severity and the disability in ...the mechanism of HIE is very helpful to the targeted therapeutic ... See full document

7

Original Article Bax inhibiting peptide reduces apoptosis in neonatal rat hypoxic-ischemic brain damage

Original Article Bax inhibiting peptide reduces apoptosis in neonatal rat hypoxic-ischemic brain damage

... During caspase-mediated apoptosis, mitochon- dria integrate lethal and survival signals and thereby play a crucial role in deciding the fate of the cell. Integral mitochondrial membrane per- meability (MMP) is key to ... See full document

8

Ubiquitin Carboxy-Terminal Hydrolase L1 (UCH-L1) is increased in cerebrospinal fluid and plasma of patients after epileptic seizure

Ubiquitin Carboxy-Terminal Hydrolase L1 (UCH-L1) is increased in cerebrospinal fluid and plasma of patients after epileptic seizure

... plasma UCH-L1 concentrations showed a strong correlation with age in patients with seizures but no correlation was found in ...neuronal injury, immature brain undergoes neuronal reorganization after ... See full document

7

MR Imaging Quantification of Cerebellar Growth Following Hypoxic Ischemic Injury to the Neonatal Brain

MR Imaging Quantification of Cerebellar Growth Following Hypoxic Ischemic Injury to the Neonatal Brain

... This study was approved by the hospital ethics committee. Parental consent was obtained for each scan. Term-born in- fants (greater than 37 weeks’ gestation) presenting with an encephalopathy and/or seizures presumed due ... See full document

6

Measurement of Lactate Content and Amide Proton Transfer Values in the Basal Ganglia of a Neonatal Piglet Hypoxic Ischemic Brain Injury Model Using MRI

Measurement of Lactate Content and Amide Proton Transfer Values in the Basal Ganglia of a Neonatal Piglet Hypoxic Ischemic Brain Injury Model Using MRI

... a hypoxic-ischemic brain impairment caused by many factors during the perinatal period and also a type of reperfusion brain injury after HI insult of the whole ...noninvasive neonatal MR ... See full document

8

Original Article Prognostic potential and oncogenic effects of UCH-L1 expression in hilar cholangiocarcinoma

Original Article Prognostic potential and oncogenic effects of UCH-L1 expression in hilar cholangiocarcinoma

... Cholangiocarcinoma, a neoplasm arising from the bile duct epithelium, is the second most common primary liver cancer in most parts of the world [1]. Although there has been some progress in therapy, the prognosis of ... See full document

10

Original Article Mechanism of kidney injury caused by bevacizumab in rats

Original Article Mechanism of kidney injury caused by bevacizumab in rats

... Forty C57BL/6 rats (Shanghai SLRC experi- mental animal Co. Ltd) weighing 18-22 g (aged 6-8 months) were housed and used in experi- ments according to the National Institutes of Health guidelines approved by the ... See full document

9

Neonatal Hypoxic-Ischemic Brain Injury: Apoptotic and Non-Apoptotic Cell Death

Neonatal Hypoxic-Ischemic Brain Injury: Apoptotic and Non-Apoptotic Cell Death

... proteins are required for initiation, vesicle elongation, autophagosome maturation, lysosome fusion, and degradation. Targeting the autophagic machinery could have significant impact in protecting the neonatal ... See full document

6

Resveratrol post-treatment protects against neonatal brain injury after hypoxia-ischemia

Resveratrol post-treatment protects against neonatal brain injury after hypoxia-ischemia

... schedule, and kept on a 12-h light/dark cycle. The hypoxia- ischemia (HI) model was produced on postnatal day 7 (P7) rat litters as described [55] with modification. Briefly, pups were anesthetized with 3% isoflurane and ... See full document

15

Original Article The expression of PI3K/Akt signaling pathway and PTEN in hippocampus of the brain and the correlation with cognitive impairment after neonatal hypoxic ischemic brain damage in rats

Original Article The expression of PI3K/Akt signaling pathway and PTEN in hippocampus of the brain and the correlation with cognitive impairment after neonatal hypoxic ischemic brain damage in rats

... the rats were returned to the dam for 1-2 h to recover from ...The rats were subsequently placed in a hypoxic chamber of 8% O 2 +92% N 2 main- tained at 37°C for 2 hour to create hypoxia- ischemia ... See full document

10

Original Article The protective effect of the Rho-kinase inhibitor hydroxyfasudil on propofol-induced hippocampal neuron apoptosis in neonatal rats

Original Article The protective effect of the Rho-kinase inhibitor hydroxyfasudil on propofol-induced hippocampal neuron apoptosis in neonatal rats

... Propofol is an intravenous agent commonly used for achieving anesthesia and sedation in children [25-27]. The mechanisms underlying propofol involve its interactions with the central nervous system at various ... See full document

9

Original Article Effects of miR-223 on cerebral ischemic injury and angiogenesis in diabetic rats

Original Article Effects of miR-223 on cerebral ischemic injury and angiogenesis in diabetic rats

... After neurobehavioral function evaluation, rats were anesthetized with 3% Pentobarbital Sodium and sacrificed by cervical dislocation. The brain was removed rapidly and frozen for 20 min at -20°C. Then the brain ... See full document

7

Neonatal dexamethasone treatment exacerbates hypoxic-ischemic brain injury

Neonatal dexamethasone treatment exacerbates hypoxic-ischemic brain injury

... of neonatal DEX treatment on HI injury in the developing ...brain injury resulting from neonatal DEX ...hancing effect of neonatal DEX treatment on glutamate- mediated ... See full document

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