[PDF] Top 20 Original Article Loss of BAP1 expression is a very rare event in gastrointestinal stromal tumors

... A loss of BAP1 expression has shown to be 100% specific for ...of BAP1 were observed in 15% of sarcomatous/desmoplastic mesotheli- ...no BAP1 loss was observed in sarcomatoid ... See full document

... cancers. Loss of p16 expression has been reported to be associated with progression to malignant disease ...some tumors, and it was associated with the aggressiveness of disease subtypes ...p16 ... See full document

... transcript expression in primary GIST was found for the CC-chemokine CCL2 ...CCR2 expression in the nucleus might directly initiate or regulate transcriptional events ...the expression of CCL2, we ... See full document

... Gastrointestinal stromal tumors (GISTs) origi- nate from Cajal cells or mesenchymal stem cells in the GI tract, and are the most common mesenchymal neoplasms of the GI tract [1, ...benign ... See full document

... DOG1 (FLJ10261, locus on human chromo- some 11q13), encoding a hypothetical protein, has been found to be specifically expressed in GISTs. Although the over-expression of DOG1 in GIST has been recently identified, ... See full document

... Eventually, 13 (81.3%) primary and 6 (50%) recurrent/ metastatic patients experienced surgical procedure. R0 resection was acquired in 18 (94.7%) patients, and minor lesions in the liver could not be removed com- pletely ... See full document

... Tumors of the IVC are uncommon malignancies with a tendency for both local recurrence and sys- temic dissemination. Surgical resection remains the therapeutic gold standard for GISTs and LMS, and tumor ... See full document

... metastatic tumors and had formalin-fixed, paraffin-embedded (FFPE) tissue available from their primary tumor and at least one metastatic ...renal tumors and contralateral renal tumors were not ... See full document

... Abstract: Gastrointestinal stromal tumors (GISTs) are relatively common mesenchymal ...with stromal tumors depends on various risk factors, including size, location, presence of mitotic ... See full document

... An Immunohistochemical and Molecular Study of Gastrointestinal Stromal Tumours ORIGINAL ARTICLE An Immunohistochemical and Molecular Study of Gastrointestinal Stromal Tumours Y T Teong, B Sc *, S T Te[.] ... See full document

... Two specialized pathologists evaluated and graded the degree of immunohistochemical staining independently. Consensus was rea- ched through rescoring when there were grad- ing discrepancies. Positive OPN staining was ... See full document

... inhibitor of KIT and PDGFRA [8], and inhibits phosphorylation and downstream KIT signaling activation. TKI is increasingly used as an adjunct to surgery to achieve dramatic improve- ments in long-term survival. TKI ... See full document

... access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the ... See full document

... other rare types and collision with multiple histological types of tumors have been reported, especially in recent years ...of tumors remains to be determined, and diagnosis of a collision tumor is ... See full document

... high-grade tumors and existing literature on pediatric GIST shows a ...cell tumors are most frequent, although in boys spindle cell tumors are reported more ... See full document

... is very rare and can be difficult to make differential diagnosis from nonfunctional adrenal ...and gastrointestinal tract was suggestive and should arouse surgeons’ ... See full document

... TKI imatinib and sunitinib proved ineffective or only partially effective, respectively, in SDH-deficient GISTs, coherently with SHD deficiency constituting a pathway independent of KIT/PDGFRA. Therefore, in the absence ... See full document

... positive expression of Pokemon and Stathmin significantly ...with stromal tumors by FDA in 2008; in addition, in our hospital, few patients had Imatinib Mesylate Capsules be- fore or after operation, ... See full document

... Case presentation: A 70-year-old woman with a past history of gastric cancer visited our hospital for regular inspection. With extensive radiological imaging, a computed tomography scan revealed a mass with a size of 6. ... See full document

... digestive tumors in 27, 12, 7, and 1 patients were diagnosed as gastric carcinoma, esophageal carcinoma, colorectal carcinoma, and pancreatic adenocarcinoma, ... See full document