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[PDF] Top 20 Original Article Overexpression of IL-12 reverses the phenotype and function of M2 macrophages to M1 macrophages

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Original Article Overexpression of IL-12 reverses the phenotype and function of M2 macrophages to M1 macrophages

Original Article Overexpression of IL-12 reverses the phenotype and function of M2 macrophages to M1 macrophages

... the IL-12 family of ...[9], IL-12 is mainly produced by dendr- itic cells (DCs), monocytes and macrophages, and exerts various aspects of roles ...that IL-12 is one of the ... See full document

10

Parasitic antigens alter macrophage polarization during Schistosoma japonicum infection in mice

Parasitic antigens alter macrophage polarization during Schistosoma japonicum infection in mice

... into M1 and M2 phenotypes in response to microorganism infection and host mediators ...that M1 mac- rophages are favorable to kill schistosomula by producing NO [3], which also plays a role in ... See full document

9

Natural killer T cell activation increases iNOS+CD206- M1 macrophage and controls the growth of solid tumor

Natural killer T cell activation increases iNOS+CD206- M1 macrophage and controls the growth of solid tumor

... and macrophages can shape the immune response ...and M2 macrophage while M1 macrophages are resistant to lysis ...[22]. IL-15 has been shown to protect NKT cells from inhibition by TAM ... See full document

13

Roles of M1 and M2 Macrophages in Herpes Simplex Virus 1 Infectivity

Roles of M1 and M2 Macrophages in Herpes Simplex Virus 1 Infectivity

... an M1 stimulus ...thus M2 macrophages, may be more effective in reducing HSV-1 latency than IFN- ␥ treatment, at least in ...the phenotype of the macrophages affects virus replication ... See full document

23

Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination with interferon-γ

Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination with interferon-γ

... While macrophages can originate from blood monocytes under inflammatory conditions, as in the classical model for macrophage development, it has recently been revealed that under non-inflammatory conditions tissue ... See full document

13

The macrophages in rheumatic diseases

The macrophages in rheumatic diseases

... peripheral macrophages infiltrate the CNS, where, together with residential microglia, they participate in the induction and development of ...activated macrophages (M1 cells), releas- ing ... See full document

11

Thioredoxin peroxidase secreted by Echinococcus granulosus (sensu stricto) promotes the alternative activation of macrophages via PI3K/AKT/mTOR pathway

Thioredoxin peroxidase secreted by Echinococcus granulosus (sensu stricto) promotes the alternative activation of macrophages via PI3K/AKT/mTOR pathway

... of macrophages related to parasitic diseases such as schistosomiasis [18, ...AAM phenotype during the late stage of ...that macrophages are also prominent in the early infiltrate, but that ... See full document

13

Original Article Gaucher disease is associated with lymph node reactive follicular hyperplasia with tingible body macrophages of M2 phenotype

Original Article Gaucher disease is associated with lymph node reactive follicular hyperplasia with tingible body macrophages of M2 phenotype

... ence that lymph node enlargement can occur at any anatomical site in GD, but limited case reports mention abdominal and mesenteric lympadenopathy causing morbidity as a space occupying lesion, and occasionally diagnosed ... See full document

8

Cell plasticity in wound healing: paracrine factors of M1/ M2 polarized macrophages influence the phenotypical state of dermal fibroblasts

Cell plasticity in wound healing: paracrine factors of M1/ M2 polarized macrophages influence the phenotypical state of dermal fibroblasts

... of macrophages after M1 or M2 ...LPS/IFNG, M1 macrophages showed a dendritic morphology while IL4/IL13 (M2) stimulated and unstimulated macrophages showed a rounded and/or ... See full document

17

Triggering TLR2, -3, -4, -5, and -8 Reinforces the Restrictive Nature of M1- and M2-Polarized Macrophages to HIV

Triggering TLR2, -3, -4, -5, and -8 Reinforces the Restrictive Nature of M1- and M2-Polarized Macrophages to HIV

... polarized macrophages explains most of their non-HIV permis- sive state. M1 polarization resulted in the marked upregulation of all TLRs except TLR5, and M2 polarization resulted in the rather modest ... See full document

13

Characteristics and potential role of M2 macrophages in COPD

Characteristics and potential role of M2 macrophages in COPD

... 1, 12 and ...1, 12 and 23, mice in the control group were given an intraperitoneal injection of phosphate-buffered saline (PBS; ...lung function measurement using a small animal ... See full document

11

Macrophage M2 polarization induced by exosomes from adipose-derived stem cells contributes to the exosomal proangiogenic effect on mouse ischemic hindlimb

Macrophage M2 polarization induced by exosomes from adipose-derived stem cells contributes to the exosomal proangiogenic effect on mouse ischemic hindlimb

... reported M2 polarization-regulating miRNAs [12, 27–31], seven of the 501 miRNAs were considered to promote M2 ...When M1 macrophages were treated with miR-21-knockdown Hyp/Exo ... See full document

14

Disabled homolog 2 controls macrophage phenotypic polarization and adipose tissue inflammation

Disabled homolog 2 controls macrophage phenotypic polarization and adipose tissue inflammation

... in M1 and M2 ...promotes M1 phenotypic polar- ization in macrophages, induces the expression of IFN consensus sequence–binding protein (ICSBP, also known as IRF8), which in turn ... See full document

13

The macrophage in HIV 1 infection: From activation to deactivation?

The macrophage in HIV 1 infection: From activation to deactivation?

... of macrophages, T lymphocytes, and NK cells [202], and TGF-b has been shown to possess neuroprotective capabilities ...TGF-b, IL-10, and TRAIL have been reported to contribute significantly to the ... See full document

15

Correlation analysis of monocyte subsets and insulin resistance considering fetuin-A involvement in patients with type 2 diabetes

Correlation analysis of monocyte subsets and insulin resistance considering fetuin-A involvement in patients with type 2 diabetes

... Although we anticipated a positive correlation between proinflammatory intermediate monocytes and fetuin-A and insulin resistance, no association was determined in this study. Perhaps, the crucial issue might be whether ... See full document

7

Myeloid HO-1 modulates macrophage polarization and protects against ischemia-reperfusion injury

Myeloid HO-1 modulates macrophage polarization and protects against ischemia-reperfusion injury

... Liver function was evaluated with standard-of-care tests, including serum ALT, AST, and total ...macrophage M1 (CXCL10, CD80, IL-1β, and MCP1) and M2 (ARG1 and CD163) polarization markers were ... See full document

15

Aedes aegypti saliva impairs M1 associated proinflammatory phenotype without promoting or affecting M2 polarization of murine macrophages

Aedes aegypti saliva impairs M1 associated proinflammatory phenotype without promoting or affecting M2 polarization of murine macrophages

... 23], macrophages also participate in the arthropod vector- vertebrate host interactions, being probably among the first cells exposed to the saliva released during the blood- ...macrophage function is ... See full document

15

TLR2 stimulation impairs anti inflammatory activity of M2 like macrophages, generating a chimeric M1/M2 phenotype

TLR2 stimulation impairs anti inflammatory activity of M2 like macrophages, generating a chimeric M1/M2 phenotype

... SF macrophages in the study of Soler Palacios et ...an M2 cell type, such as increased CD14 and CD163 levels (as measured by MFI) or superior IL-10 expression compared with their generated M1 ... See full document

13

Interferon-γ and celecoxib inhibit lung-tumor growth through modulating M2/M1 macrophage ratio in the tumor microenvironment

Interferon-γ and celecoxib inhibit lung-tumor growth through modulating M2/M1 macrophage ratio in the tumor microenvironment

... We implanted mouse LLC1 cells subcutaneously into syn- geneic C57BL/6 mice. The mice were randomly assigned into five groups: a) treated with saline as the placebo con- trol group, b) treated with IFN γ , c) treated with ... See full document

12

Macrophage Polarization in Inflammatory Diseases

Macrophage Polarization in Inflammatory Diseases

... pulmonary macrophages contributes to the patho- genesis of asthma ...that M2 phenotype macrophages take a leading role in asth- ma, which they are beneficial for tissue repairing and ... See full document

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