Cervicalcancer is the third most common malignant tumor worldwide in women popula- tion [1, 2]. Annually, there are about 510,000 new cases globally, of whom, about 150,000 in China represent ~30% of all new cases. Each year, around 200,000 women die of cervicalcancer, among whom, about 53,000 patients were from China, accounting for ~40% of the overall mortality . Statistically, the mean age of onset was 45 years with a peak age under 30 in China [4, 5]. In recent years, the epidemic areas in China have been spreading gradually from impoverished mountainous areas to coastal economic regions, maybe because of the increased incidence of human papilloma virus (HPV) infection. Over the past several decades, a great many of patients have died of cancer metastasis and recurrence, yielding a 5-year survival ranged from 50% to 90%,
earlycervicalcancer with intermediate riskfactors that meet the Sedlis criteria (category 1), according to the National Comprehensive Cancer Network guidelines. However, the advantage of postoperative CCRT is not clear. Currently, there are no prospective randomized controlled clinical tri- als investigating the impact of CCRT for intermediate-riskpatients. We were able to identify 6 retrospective studies that gave inconsistent findings. Mabuchi et al found that CCRT prolonged PFS and OS. 12 Similarly, Song et al 13 observed that
Statistical analyses were performed using SPSS version 21.0 (SPSS Inc., Chicago, IL, USA) or GraphPad Prism 6 software (GraphPad Software, San Diego, CA, USA). A P<0.05 was considered statistically significant. Nonpara- metric Kruskal-Wallis test was used to compare the differences in serum miR-142-3p expres- sion among experimental groups. The diagnos- tic value of serum miR-142-3p was evaluated by receiver operating curves (ROCs). Association between serum miR-142-3p and clinicopatho- logical parameters was analyzed by Chi- squared test. Cox proportional hazards regres- sion was performed to explore the independent prognostic factors. For the TCGA database
Abdominal fascia reaches 70-80% of former tension strength at 120 days and 73-93% at 140 days after operation . Until recently, IH was assumed to result mostly from a technical failure in surgical closure of incision . Currently it is has been established that pa- tients related factors, surgical and postopera- tive factors which all affect normal wound heal- ing, also influence their development. Yet, pre- disposition to IH is in fact detectable very early in the postoperative period as various degrees of separation of the rectus muscles, but other factors probably determine if and when they become clinically detectable . According to the current study, after analyzing the potential riskfactors, independent positive predictors for IH were age, SSI, adjuvant chemotherapy and duration of follow up.
Cervicalcancer is the second leading cause of death among women worldwide, with an esti- mated 530000 deaths per year . Although it has made a notable progress with treat- ment developed, including surgical techni- ques, chemotherapy, and radiotherapy in the past two decades, there are still some early cases appeared invasion and metastasis, which directly affected the prognosis of cervi- cal cancer . In recent years, the incidence of cervicalcancer increases every year, most of them are squamous cell carcinoma, and patients tend to be increasingly younger, it had became a serious threat to women’s lives and health . Therefore, an exploration of the molecular pathogenesis of cervicalcancer and the identification of potential markers for early detection may play a significant role in treat- ment and prognosis.
Anterior cervical spine surgery is commonly performed to treat many spine conditions, including trauma, tumor, and degenerative spi- nal disease; however, postoperative dysphagia is a common complication following the anteri- or approach [1, 2]. According to previous stud- ies, the reported incidence of dysphagia varies widely and ranges from 4.8%-71% [3-5]. The wide range may reflect different definitions of dysphagia and variable lengths of follow-up in different studies. Although dysphagia is usually benign and transient, in several situations, it can induce severe problems, such as aspira- tion pneumonia [6, 7]. Joseph et al. reported that dysphagia in patients who undergo cervi- cal spine surgery correlates with significantly
Lung cancer is the most commonly diagnosed cancer as well as the leading cause of cancer- related mortality worldwide, with over 1 million deaths each year , and although significant advances have been made with therapies, the 5-year survival rate of lung cancer is below 20% . The best chance of achieving long-term sur- vival is in complete surgical resection; however, even in resected stage IA patients, 30% suc- cumb from their disease within 5 years . Previous studies have reported several factors associated with poor prognosis in non-small cell lung cancer (NSCLC) patients after surgical resection, such as tumor size, preoperative serum CEA level, visceral pleural invasion, vas- cular vessel invasion, and histological grade [4-8]. In addition, recently, advances in molecu-
the effects of the cancerpatients’ psychologi- cal well-being on the prognosis and their quality of life. Some studies have found that the emo- tional and quality of life of patients with cancer have been improved when they receive atten- tion and counseling . Patients tend to regard cancer as a source of stress. Thus, active and proper responses with this stress may lead to a better prognosis of the disease [27, 28]. Previous studies on the quality of life of patients with cervicalcancer have found that the effect of physical pain is relatively signifi- cant. Additionally, in emotional function, pa- tients may tend to have psychological shadow and bad psychological mood [29, 30]. This study also found that the quality of life score of the observation group was significantly better than that of the control group after the nursing intervention and the observation group had better results in emotional function and somat- ic pain, which were consistent with the men- tioned previous research.
Cervicalcancer (CC) is one of the most com- mon female cancers and also one of the impor- tant causes of cancer-related deaths all over the world [1, 2]. Every year, about 273,000 pa- tients died of CC globally, which mainly occurs in developing countries [3, 4]. As CC patients at early stage have no obvious signs and symp- toms, they are often diagnosed at an advanced stage . Currently, the potentially curative and optimal treatments for CC patients are mainly radiotherapy, surgical resection and chemo- therapy [6, 7]. However, effective treatment options for CC patients with an advanced stage are limited and 30-35% of them are failed in the treatments . Besides, the 5-year survival rate of patients with early stage could achieve 90%, while that of those with advanced stages are less than 40% [9, 10]. Therefore, identifica- tion of novel biomarkers for prognosis of CC patients is urgently needed.
and increasing the risk of loss of information. Second, the data used in this study covered a long period of 10 years. The adjuvant chemo- therapy had achieved remarkable progress during this 10-year period. In another word, the presence or absence of postoperative chemotherapy may have altered survival in these patients. So the changes in the drugs used for adjuvant chemotherapy will likely affect the long-term survival outcomes of the patients. There also was a major difficulty that was to identify the principal anatomic indi- cation of bilobectomy, occasionally rendering distinction very difficult, particularly in larger masses requiring lower-middle bilobectomy, due to a large central mass crossing the fis- sure and invading the 2 bronchi.
prehensively. Second, the analyzed PPCs con- sisted of pulmonary edema, atelectasis, pneu- monia, ARDS and respiratory failure. Third, a risk prediction analysis predicting PPCs after thoracic surgery was described from preopera- tive and intraoperative variables, and further analyzed by multivariate logistic regression. In present study, age, history of smoking, com- orbidities of COPD, CKD and liver disease, type of surgery and PCA, method of operation and the intraoperative blood loss, urinary volume, accumulation of lactate, transfusion of crystal- loids and colloids were associated with PPCs. Similarly, Agostini et al. only reported age, BMI, ASA classification, smoking history and COPD as predictive riskfactors for PPCs . The risk of lung cancer rises with age, most patients undergoing lung cancer are over 50 years old and over one-third are older than 65 years . Elder patients favored unsatisfactory physical status and high risk for major surgery. Although advanced age tends to with a higher incidence of coexisting comorbidities, itself is an inde- pendently powerful predictive risk factor. The impact of advanced age to PPCs may be diff- erent according to the methodology used to assess its contribution. We found a significantly higher contribution of advanced age for PPCs. Smoking has been shown as a PPCs risk fac- tor for major surgery other than thoracic. Of the various smoking-associated diseases, lung Table 5. Riskfactors for PPCs by multivariate analysis
ioral cognitive psychological care was given. The nursing staff guided the patients to gradu- ally learn to respond reasonably, correctly understand themselves, strive for social sup- port and rebuild self-esteem, mobilize the sub- jective initiative, and guided the patient to carry out progressive relaxation training; (3) continu- ing nursing: after discharge from the hospital, weekly follow-up by phone, or WeChat was car- ried out. A more comprehensive assessment of the patient’s condition was provided, and the continuing nursing plan was revised based on the assessment. The main content included guiding patients to do self-care, such as physi- cal exercise, rational medication, nutritional guidance, and continuing to guide patients to
Kaplan-Meier overall survival curve of the cervi- cal cancerpatients according to the status of lncRNA-ATB level was examined. The overall survival of patients in the high lncRNA-ATB group showed significantly worse survival rates than those who were in the low lncRNA-ATB group (P=0.024, shown in Figure 2), suggesting that high expression of lncRNA-ATB is associat- ed with poor prognosis in cervicalcancerpatients. A multivariate analysis of the progno- sis factors with a Cox proportional hazards model showed that high lncRNA-ATB expres- sion (HR=2.535, CI: 1.372-10.376, P=0.012), high FIGO stage (HR=4.551, CI: 2.017-12.895, P=0.002), and worse tumor differentiation (HR=3.123, CI: 2.128-9.067, P<0.001) were significant independent predictors of poor sur- vival in cervicalcancer (shown in Table 2). Discussion
Abstract: Background: Esophageal cancer is the sixth-most common cause of cancer-related death worldwide. Sur- gery is the gold standard treatment for resectable esophageal cancer, and McKeown esophagogastrectomy—one of the most frequently performed operations in these cases-is often associated with severe postoperative infection. Aim: To analyze the riskfactors of postoperative infection in patients who have undergone McKeown esophagogas- trectomy. Methods: We retrospectively investigated the clinical data of 428 patients who have undergone McKe- own esophagogastrectomy, and divided them into infection and non-infection groups. Data were analyzed using SPSS 22.0 software. Results: Between the infection and non-infection groups, smoking status (66.7% vs. 49.2%; P=0.007), male gender (86.1% vs. 74.7%; P=0.037), hoarseness (23.6% vs. 12.4%; P=0.013), poor coughing ability (51.4% vs. 13.2%; P<0.001), preoperative white blood cell (WBC) count (7.64±2.86×10 9 /L vs. 7.04±2.27×10 9 /L;
Cervicalcancer is the fourth most common malignancy in women worldwide; indeed, it re- mains a leading cause of women’s death . Although cervicalcancer can be detected ear- ly thanks to advanced screening systems and the fact that is symptomatic at early stages, advanced cases requiring multimodal treat- ment including chemotherapy, radiation and other modalities continue to be diagnosed. Ch- emo-radiation therapy has produced favorable responses in patients with advanced cervicalcancer. However, some cancer cells acquire re- sistance to chemo-radiation; difficult to fully eradicate, they are often the eventual cause of death. Cancer cells that are resistant to chemo- therapy and radiotherapy have properties of cancer stem cells (CSCs) that are implicated in treatment failure [2, 3].
In summary, our study examined the role of postopera- tive adjuvant CT combined with intracavitary brachytherapy for treatment of early-stage cervicalcancerpatients with intermediate riskfactors. These treatment strategies achieved the equivalent of 3-year PFS compared with CCRT and RT, but with lower acute and late-grade toxicities. Therefore, CT combined with intracavitary brachytherapy may be worth reconsidering as an alternative postoperative therapy for patients with cervicalcancer. Due to the nonrandomized design of the study, a trial with an expanded sample size and longer follow-up period is required to confirm our initial observations.
consent form was signed by each participating patient. All tumors were histologically proven to be invasive ductal adenocarcinomas of the pancreas. Preoperative tumor markers, abdom- inal ultrasound scan (US), contrast computed tomography (CT)/positron emission tomogra- phy (PET), contrast nuclear magnetic reso- nance (MRI) and surgical exploration were used to ensure whether all PC patients meet our resection criteria as Sugiura et al. previously reported , including: a) no distant metasta- sis, b) no evidence of tumor extension to the superior mesenteric artery or hepatic artery in PC, c) according to 7th edition of UICC 2010 TNM classification, all patients were identified as UICC stage ≤ IIB and T stage ≤ T3. Based on above criteria, between 2004 and 2014, 189 consecutive PC patients underwent radi-
As one of the most common gynecologic malig- nant tumors, cervical carcinoma has caused great damage to the physical and mental health of woman. Currently, its treatment regi- men is mainly based on a comprehensive con- sideration of the overall condition of tumor staging, patients’ age and reproduction require- ment [7, 8]. Although surgical and chemoradio- therapy technologies have been improved con- tinuously, the problem of patients’ high recur- rence rate after radical trachelectomy hasn’t been solved yet . Therefore, it is of great significance to investigate riskfactors affecting patients’ postoperative recurrence and then establish a proper comprehensive treatment regimen accordingly for preventing the recur- rence of cervical carcinoma after operation and improving therapeutic effect and patients’ quality of life.
For patients with EGC, the choice of an appro- priate surgical approach relies on the accurate assessment of the depth of invasion, histologi- cal type and condition of LNMs prior to surgery. The identification of LNM can be achieved via CT or endoscopic ultrasonography. If neces- sary, we can perform a biopsy to determine the depth of infiltration in order to choose a reason- able surgical method. With respect to patients with high riskfactors, we recommend ESD com- bined with lymphadenectomy under laparo- scope (LLND). In a group of 21 patients with high riskfactors, Abe et al.  found the pres- ence of LNM in two of 21 patients. Two patients who had LNM were followed without any addi- tional surgery. During the median follow-up of 61 months, all patients were alive without any recurrence. Therefore, ESD combined with LLND may be an effective and minimally inva- sive approach for EGC patients with potential risk of LNM, maintaining the patient’s long-term quality of life.
Abstract: Background: The median age of patients with pancreatic ductal adenocarcinoma (PDAC) is approximately 70 years, and it rarely affects individuals younger than 45 years, when it is defined as early-onset pancreatic cancer (EOPC). Little is known about riskfactors and outcomes for EOPC patients. Aim: To evaluate the clinico-pathological features, riskfactors, and outcomes of EOPC. Methods: A retrospective analysis of pancreatic cancerpatients diag- nosed between January 1999 and December 2014 was performed. Information about environmental riskfactors, clinical characteristics, treatment, and survival was collected. The riskfactors of EOPC patients were compared to normal-onset pancreatic cancer (NOPC) patients. Results: Of 1789 patients with pathologically proven PDAC, 156 (8.7%) had EOPC. There was no difference regarding alcohol use, BMI, weight loss, and tumor location between EOPC and older subjects. EOPC patients were more likely to be male (75 vs. 63.9%) and to have a history of tobacco use (34.6% vs. 25.9%), compared NOPC patients. Among the 156 EOPC patients, there were 117 (75%) males, and 39 (25%) females, from 17 to 45 years old. Fifty-four (34.6%) had a smoking history, 55 had used alcohol, and 27 (17.3%) had a family history of cancer. For treatment, 32 underwent surgery to attempt curative resection of localized disease and 74 had palliative surgery. The median overall survival for the 156 EOPC patients was 8±0.5 months, with 1.2 years survival rates of 25.4 and 8%, respectively. For EOPC patients, the median overall survival of the patients treated with radical resection, palliative surgery, and medical treatment was 19±2.5, 8±0.6 and 6±0.3 months, respectively. The 1-year survival rates were 77.5, 17.6 and 4%, respectively. Survival analysis showed that the tumor size, tumor location, differentiation, treatment procedure, TNM stage, and first symptoms were associated with the overall survival (P < 0.05). Cox regression revealed that the TNM stage (RR=3.427; 95% CI: 1.802-6.519) and tumor size (RR=1.911; 95% CI: 1.054-3.463) are independent prognostic factors for EOPC patients. Conclusion: EOPC was associated with male gender and smoking history. Although EOPC patients display aggressive disease and have a worse outcome, radical resection is the best treatment. The TNM stage and tumor size are independent prognostic factors.