[PDF] Top 20 Original Article Study on inhibitory effect of metformin in bladder cancer and its mechanism

... hole and cultured in an incubator for overnight at 37°C and 5% CO 2 . The next day, remove the medium in the hole and replenish with culture medium containing 100 μL metformin at differ- ent concentrations (2, 5, ... See full document

... of metformin were firstly evaluated on breast cancer cells [24, 25], in which AMPK was primarily activated and mammalian tar- get of rapamycin (mTOR) signaling and protein synthesis were subsequently ... See full document

... tion mechanism in gene regulation, so it can relive the damage caused by ionizing radiation ...lung cancer cells showed relatively slow proliferation and were prone to apoptosis under a low dose of ionizing ... See full document

... ble mechanism of 5F in inducing the apoptosis of lung ...ent study, the expression levels of Bcl-2 were obviously reduced in the groups receiving 5F treatment and blank group compared to model group with ... See full document

... receptors. Its main function is to bind to the ligand and initiate the ...of cancer [25]. In this study, we used curcumin to interfere the TGF-β1- induced EMT of SGC7901 ...inhibition effect ... See full document

... lung cancer is a complex prog- ress involving many factors, multiple gene changes and several stages ...in-depth study of lung cancer’s molecular biological features is of great clinical signifi- cance for ... See full document

... Current study indi- cates its strong anti-oxygenation and anti- angiogenesis, which bestows value on celastrol as a bioactive natural product ...Previous study demonstrated the inhibition ... See full document

... the mechanism of the anti-cancer effect of β-elemene remains largely ...this study, we found that β-elemene inhib- ited the viability of breast cancers in vitro in a dose- and time-dependent ... See full document

... dominant mechanism for the apoptosis-induc- ing effect of cucurbitacins are their ability to modify mitochondrial trans-membrane poten- tial and regulate the expression of genes relat- ed with ...molecular ... See full document

... This study aimed to detect the expression of Slit signaling protein ligand Robo protein in human bladder cancer and para-carcinoma tissue, and observe the tumor cell survival and growth by ... See full document

... pancreatic cancer and breast cancer. The aim of this study was to analyze the expression of COUP-TF2 in human bladder cancer to evaluate the relationship between COUP- TF2 expression ... See full document

... and metformin (Met) may possess an anti-breast cancer effect besides anti-diabetic ...current study, we synthesized glimepiride-metformin adduct (GMA) and examined its ... See full document

... instance metformin and cisplatin synergistically re- duced size, proliferation and mitotic count of OC tu- mours in mice ...[59]. Metformin was shown also to potentiate the cytotoxic effects of carboplatin ... See full document

... this study indicated that Aliskiren could inhibit the mRNA and protein expressions of MMP-2 and MMP-9 in a dose-dependent manner, sug- gesting that Aliskiren might inhibit the angio- genesis and stabilize the ... See full document

... synergistic effect was found in enhancement of ...when bladder cells were co-treated with LY- ...synergistic effect of EGCG with PI3K/AKT inhibi- tor to induce apoptosis might be via activation of ... See full document

... protective effect on the central nervous system ...great inhibitory effect on exudation or infiltration of neutrophils ...plays its neuroprotective role by reducing the infiltration of ... See full document

... of bladder cancer, while bladder cancer cell implantation without bladder mucosa injury could not induce the incidence of bladder ...vivo study demonstrate that Ad-VEGFR ... See full document

... lung cancer, metformin could activate AMPK and then inhibit mTOR sig- naling pathway, which could thus facilitate the apoptosis of cells ...ian cancer cell line. However, metformin could ... See full document

... molecular mechanism of miR-517a-3p in diseases, only several studies have reported its possible target ...lung cancer [23], and miR-517a-3p could directly modulate FOXJ3 expression by binding to ... See full document

... Diabetic bladder dysfunction (DBD), also known as diabetic cystopathy (DCP), is a common complication of diabetes mellitus (DM) ...synergistic effect of the muscle- derived and neurogenic factors leads to ... See full document