[PDF] Top 20 Oval Cells: Potential Role in Liver Regeneration

... The liver and the pancreas share a common developmental origin and a bipotential precursor cell population for these organs has been identified within the embryonic ...that liver stem/progenitor ... See full document

... The potential role of epidermal growth factor (EGF) in the regulation of rat liver regeneration was examined by assessing the binding of 125I-EGF to hepatic membranes isolated at various times ... See full document

... of liver development are highly relevant to creat- ing new stem cell therapies, an understanding of liver regenera- tion has important implications for improving current methods of differentiating and ... See full document

... of liver injury, including alcohol toxicity and submassive parenchymal necrosis as well as experimental injury models featuring blocked hepatocyte repli- ...cation. Oval cells can potentially become ... See full document

... ones, liver regeneration could not be fully assessed in these chemical injury models ...that oval cells play minor if any contribution to liver regeneration in conventional ... See full document

... established liver progeni- tor cells, which are called oval cells in rodents, could represent an intermediate stage during hepatic differentiation of stellate cells or other ...MSCs. ... See full document

... the potential contribution of intrahepatic and BM cells to liver ...intrahepatic cells that are capable of differentiating into hepatocytes and ...therapeutic potential. Meanwhile, ... See full document

... The liver is an essential organ that aids in metabolic processes, protein synthesis and detoxification of harmful ...the liver is able to compensate for this routine damage with its robust regenerative ... See full document

... of cells in the neonatal enthesis that are positive for Gli1, a transcription factor that is a downstream target of the activated hedgehog (Hh) signaling pathway (Dahmane et ...the potential for enthesis ... See full document

... Control cells were incubated with isotype-matched, fluorochrome-conjugated ...IFN-γ, cells were stained with antibodies against surface antigens, incubated with eBioscience Intracellular Fixation Buffer ... See full document

... Ito cells) have been subject of ...a role in ending the re- generation, however in transgenic mice overexpressing TGF- β 1 regeneration is slowed down but it finally comple- tes (5, ... See full document

... Liver regeneration is an amazing phenomenon, in which removal of a portion of the liver induces remaining cells to proliferate to restore organ ...the liver to regenerate has been ... See full document

... initiated oval cell proliferation during ductular reaction in small-for-size fatty grafts after ...rat liver transplantation model and human post-transplant grafts, the proliferative oval ... See full document

... Role of BM-derived SPCs in liver regeneration. LSECs were isolated on day 3 after PHx from wild-type rats that had been transplanted with BM from Lew-Tg(CAG-EGFP)ys rats. (A) Hgf mRNA expression was ... See full document

... in liver regeneration, in cirrhotic livers and ...metastatic potential of HCC cells with en- hanced growth activity and increased lev- els of ALR depends on the ratio of mito- chondrial- and ... See full document

... heart, liver, intestinal, and lung ...These cells are relatively easy to expand, maintain, and cryopre- serve, while maintaining their ...differential potential towards adipocytes, osteoblasts, and ... See full document

... To assess whether over- or under- expression of p75NTR effectively promotes neuron survival, we will co-culture each PNS cell line with and without either soluble MAG or pre- cultured Schawnn cells (Tebu-Bio). ... See full document

... cirrhotic liver only during the early ...duct cells with EpCAM and Jagged-1 expression were identified in the cirrhotic liver of rats fol- lowing BMSCs ...EpCAM-positive cells in the cirrhotic ... See full document

... resident, liver stem/progenitor cells (LSC) are also candidates for liver cell therapy in preclinical and clinical studies ...stem cells reside in tissues and play a key role in replen- ... See full document

... of liver regener- ation or enabling patients to buy time before liver transplantation ...stem cells contribute to alleviating the liver dysfunc- ...the potential mechanisms involved are ... See full document