[PDF] Top 20 Oxidation of DNA by Long-range Charge Transport

... When intercalators were tethered directly to the 5' terminus of the triplex-forming strand as opposed to the center, significant amounts of oxidative damage was generated only in t[r] ... See full document

... active; DNA-mediated oxidations are exceedingly rapid (on the picosecond to nanosecond timescales) if the species to be oxidized is well coupled into the base ...permanent oxidation products are instead ... See full document

... of long-range guanine oxidation was compared with the thermodynamic stability of the mismatch- containing duplexes and although a correlation exists, the trend most closely correlates with base-pair ... See full document

... of DNA-mediated charge transport has been extensively ...is DNA-mediated charge transport an issue, indeed perhaps even a useful reaction, within the cell? It is well established ... See full document

... in DNA is DNA-mediated charge transport ...obases, DNA can serve as a bridge in long-range electron transfer (ET) ...and DNA, 11 DNA-mediated CT results in ... See full document

... on long-range guanine oxidation (10), and they concluded that any attenuation in long-range oxidation arose from a competition between trapping of a guanine radical at the ... See full document

... Electrostatic DNA-Protein Binding ...between DNA and proteins upon the addition or removal of an electron at the [4Fe4S] metallocofactor (Figure ...the DNA-binding pocket from published literature ... See full document

... the charge transport pathway of ...Tyrosine oxidation products were not seen in the MS peptide ...the oxidation of the quadruple mutant are statistically identical with those of the triple ... See full document

... that DNA-mediated CT can trigger MutY, we have examined yet another system that includes a metallo transcription factor, ...for oxidation in the cell is ...reversible oxidation of the [2Fe2S] ... See full document

... how DNA repair proteins with 4Fe-4S clusters utilize DNA-mediated CT chemistry as a means of signaling has been proposed by our ...model, DNA-processing enzymes with 4Fe-4S clusters use ... See full document

... the charge carrier ...of charge transfer mecha- nism in DNA [30] allowing the basic charge carriers (holes) to jump from one base to another with increasing their transfer rate for the ... See full document

... own DNA and also harbor an abundance of reactive oxygen species as a result of their function in oxidative phosphorylation ...mitochondrial DNA have been found in a variety of tumors and are associated with ... See full document

... about two orders of magnitude and the lattice symmetry is lowered from cubic to monoclinic. Despite intensive re- search spanning almost a century, the nature of the Verwey transition is not completely understood. ... See full document

... immediately after a linear increase at lower fields. The transition to the sub-linear region occurs when approaches the velocity of sound u,„ in the medium. In the high electric field region a saturated curve of the ... See full document

... double-stranded DNA probe with a 6-base overhang (probe ...a long DNA duplex, which has a nick in sugar-phosphate backbone of each strand, is formed on the ...affect DNA mediated charge ... See full document

... between DNA- modified electrodes on different chips, but this is not expected to be a significant contribution; batch processing of multiplexed chips ensures uniform gold electrode surfaces (60) and the consistent ... See full document

... A charge carrier density dependence in the mobility even at low concentrations has been observed in P3HT:PCBM blends [73], and we note that a concentration dependence might cause dispersion as carriers gradu- ally ... See full document

... Molecular charge transport (CT) has been subject to extensive theoretical and experimental studies, 1-4 since nanoscale device elements provide both novel sensing platforms and the potential to extend ... See full document

... by oxidation of various precursors, including fluorotelomer alcohols, FTOH, and perfluorooctanesulfonamides and - sulfonamido ethanols (FOSE), see Figure ... See full document

... of DNA on planar electrodes and effectively control the homogeneity and spacing of the DNA duplexes within a sensing ...Conventional DNA-modified electrode surfaces are formed through the ... See full document