[PDF] Top 20 Paget’s disease of bone: an osteoimmunological disorder?
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Paget’s disease of bone: an osteoimmunological disorder?
... from bone marrow to peripheral circulation, mature in thymus gland, and then some return to peripheral circulation where they become mature ...exaggerated bone destruction in inflammatory arthritis in ... See full document
13
Emerging strategies and therapies for treatment of Paget’s disease of bone
... Paget’s disease of bone (PDB) is a progressive monostotic or polyostotic metabolic bone disease characterized by focal abnormal bone remodeling, with increased bone resorption ... See full document
15
<p>Response to Pyrotinib in a Chinese Patient with Bone-Metastatic Scrotal Paget’s Disease Harboring Triple Uncommon HER2 Mutation: A Case Report</p>
... pyrotinib treatment, the general pain and discomfort symptoms were signi fi cantly relieved, platelets and hemoglobin were increased (Figure 3). The Mefecon use dose for bone pain was also decreased to 1/3 of the ... See full document
5
Current perspectives on bisphosphonate treatment in Paget’s disease of bone
... In spite of that, there were no significant differences identified in quality of life, overall bodily pain, or in pagetic bone pain between the groups. Similarly, hearing thresholds, as assessed by audiometry, did ... See full document
7
Current options for the treatment of Paget’s disease of the bone
... can be associated with esophageal irritation and upper gastrointestinal discomfort that can be generally more fre- quent than in oral regimens used to treat osteoporosis due to the cumulative higher dosages. Moreover, ... See full document
14
Paget disease of bone
... congenital disorder that occurs in childhood and is characterized by deafness and bone lesions that affect the entire skeleton (82), but OPG muta- tions have not been reported in adults with ... See full document
10
Skull radiographs as a guide for diagnosing systemic disorders (Pictorial Atlas)
... This is due to failure to replace immature woven bone with mature lamellar bone. Mabry syndrome - Mental retardation with hyperphosphatasia. Although the entire skeleton may be involved the skull ... See full document
10
Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant
... early-onset Paget disease and frontotemporal dementia (IBMPFD) ...inherited disorder with variable penetrance of 3 predominant phenotypic features, ...opathy, Paget disease of ... See full document
14
Clinical Reasoning: Progressive proximal weakness in a 56-year-old man with bone pain
... Rimmed vacuoles are a nonspecific finding in many myo- pathies, including sporadic IBM (sIBM) and myofibrillar myopathy (MFM). As noted previously, the patient’s pattern of muscle involvement was not typical for sIBM. There ... See full document
7
Chronic Kidney Disease-Mineral and Bone Disorders (CKD-MBD)
... lethal disorder characterized by systemic medial calcification of arterioles, which leads to ischemia and subcutaneous necrosis ...this disorder has appeared to be increasing ... See full document
19
Rasagiline in treatment of Parkinson’s disease
... Subjects were randomly assigned to either 1 mg/day rasagiline, 200 mg entacapone with every levodopa dose, or placebo. Levodopa dosage could be reduced in the initial 6 weeks but no change could be made subsequently. The ... See full document
10
Sleep disorders in Parkinson’s disease
... divided into disturbances of sleep and wakefulness. Disturbances of sleep include insomnia, restless legs syndrome, rapid eye movement (REM) sleep behavior disorder, sleep apnea, and parasomnias. Disturbances of ... See full document
6
Olfactory dysfunction in Alzheimer’s disease
... Alzheimer’s disease (AD) is a common neurodegenerative disorder with the earliest clinical symptom of olfactory dysfunction, which is a potential clinical marker for AD severity and ... See full document
7
<p>Rapidly Progressing Neurocognitive Disorder in a Male with FXTAS and Alzheimer’s Disease</p>
... worsened after he developed chronic urinary tract infec- tions. Since that time, he also had a mild but progressive renal failure. At age 76, he started to feel numbness in both feet and right thigh. At age 77, he was ... See full document
8
Role of berberine in Alzheimer’s disease
... Alzheimer’s disease (AD) is an irreversible devastating neurodegenerative disorder, which affects the growing aging ...“Alzheimer’s disease” patient, Auguste D, was reported in November 1906 in the ... See full document
12
Targeting neuroinflammation in Alzheimer’s disease
... treatments that would be able to stop or better prevent the disease. At present, AD is incurable. Despite the huge amount of preclinical and clinical investigation, medica- tions currently used provide only a ... See full document
10
Cerebral small vessel disease and Alzheimer’s disease
... Binswanger’s disease is often associated with advanced age, chronic hyper- tension, stroke, disease of the large blood vessels in the neck, alcohol and smoking, and cardiovascular ...Binswanger’s ... See full document
10
Cytological and cytometric analysis of oral mucosa in patients with Alzheimer’s and Parkinson’s disease
... In our study, we could not reach a conclusion that oral cytological evaluation helped early diagnosis. Our findings suggest that further study is needed to clarify the effect of neurodegenerative diseases on buccal ... See full document
6
<p>Validation study of the Parkinson’s Fatigue Scale in advanced Parkinson’s disease</p>
... Two patients (3.3%) were excluded from the analysis due to a lack of responses on the PFS-16; the reasons for this lack of response are unknown. In the remaining sam- ple, 0.31% of the data was missing, but these values ... See full document
12
Mineral bone disorders (MBD) in patients on peritoneal dialysis
... Nevertheless, the target values for serum P, Ca, and PTH in PD patients are the same as those in HD patients. In PD patients, however, it is plausible to initiate correction of any of these values once any tendency ... See full document
6
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