[PDF] Top 20 Hsp27 participates in the maintenance of breast cancer stem cells through regulation of epithelial mesenchymal transition and nuclear factor κB

... Results: Hsp27 and its phosphorylation were increased in ALDH+ BCSCs in comparison with ALDH- ...of Hsp27 in breast cancer cells decreased characters of BCSCs, such as ALDH+ population, ... See full document

... arise through de regu- lated expansion of this MaSC ...immune cells, growth factor signaling, hypoxia), it may endow subsets of cancer cells with the migratory, invasive and ... See full document

... of cancer treatment. Loss of the tumor suppressor p53 in mammary epithelial cells has been shown to induce EMT and enrich CSCs through repression of miR200c, suggesting that the p53–miR200c ... See full document

... the maintenance and survival of these ...regulate stem cell behavior originate in the stem cell ...cer stem cell microenvironments in different malignancies, it is clear that tumor growth and ... See full document

... in breast carcinomas ...transcription factor phosphorylation is closely related to gene transcriptional regulation ...in breast cancer tissues than matched adjacent noncancerous ...MCF7 ... See full document

... EMT through a transcriptional repressor complex containing Snail and histone deacetylase 1 and ...E-cadherin through binding of E-boxes in the promoter region, and also through regulation of ... See full document

... -/low cells, being poten- tial cells-of-origin for metastatic growth, are currently being evaluated as therapeutic ...e stem cell niche may also furnish CSCs with a means to evade chemotherapy ... See full document

... transcription factor family member and is essential for the maintenance of self- renewal in embryonic stem cells [9, ...transcription factor, and Nanog and Oct-4 induce the expression ... See full document

... Nuclear translocation of STAT3 under the effect of EGF was cut down in shAnxa2 cells (Figure 7B). A dual-luciferase reporter assay system was used to study the effect of Anxa2 on STAT3 transcriptional ... See full document

... in Nuclear factor-κB (NF-κB) dependent manner in response to matrix metalloproteinase-3 (MMP-3) ...in breast cancer cells (Figure ...in cancer cells [52, ... See full document

... of cells through an EMT and the acquisition of mesenchymal properties is associated with increased migratory and invasive ...HMLE–Snail cells through matrigel using Transwell migra- ... See full document

... in breast cancer and FOXO are required for ...repress cancer stem cells and the mesenchymal ...suppressed breast cancer cell migration and invasion and altered ... See full document

... initialized through posttranslational activation of the Gli family of zinc-finger transcription factors (Gli1, Gli2, and Gli3) ...the maintenance of breast CSC properties ...in breast ... See full document

... Cancer stem cells (CSCs) are endowed with stem cell properties, which include the ability to self-renew and differentiate by symmetrical or asymmetrical cell div- ...progenitor cells ... See full document

... acetylation through prevention of recruitment of a deacetylase-containing complex may be the initial route for epigenetic remodeling in response to inhibition of PAH2 ...embryonic stem cells [47] or ... See full document

... ABSTRACT Epithelial-mesenchymal transition (EMT) is a developmental process defined by loss of epithelial characteristics and acquisition of mesenchymal ...of breast carcinoma to ... See full document

... occurs through the low- affinity lactate transporter MCT4 (Km≈28 mmol/L), the import of lactate occurs through the high- affinity MCT1 transporter (Km≈1– ...EMT-induced mesenchymal cell lines ... See full document

... in epithelial cells undergoing EMT in post-treatment ...breast cancer. A better understanding of the role of EMT and CSCs in breast cancer will lead to more eff ective therapies ... See full document

... of breast carcinoma, both in murine models and in ...the transition from the epithelial to mesenchymal phenotype, and the reverse ...normal-like epithelial cells undergoing ... See full document

... stability through RNF8-mediated K-63 ubiquitination [34, ...or nuclear expression of RNF8 is higher in lymph node metastases than in the corresponding primary ...signaling through shuttling from ... See full document