[PDF] Top 20 B cells from patients with systemic lupus erythematosus display abnormal antigen receptor mediated early signal transduction events
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B cells from patients with systemic lupus erythematosus display abnormal antigen receptor mediated early signal transduction events
... SLE patients (18 women, 3 men) were stud- ...the patients ranged from 20 to 76 yr (mean 6 SD 5 44 6 14.2). Patients who were receiving glucocorticoids were studied at least 24 h after their ... See full document
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Impaired TLR9 responses in B cells from patients with systemic lupus erythematosus
... SLE patients’ treatments were the cause of this defect, as patients without steroids, without hydroxychloroquine, or even untreated patients displayed decreased CD19/CD21 expression (Supplemental ... See full document
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Expression of CXCL12 receptors in B cells from Mexican Mestizos patients with systemic lupus erythematosus
... coupled receptor family ...of B-cell mediated autoimmune diseases including SLE ...main receptor CXCR4, constitutes the chemokine/receptor axis attracting the greatest level of interest ... See full document
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Spontaneous immunoglobulin A secretion and lack of mitogen responsive B cells in systemic lupus erythematosus
... of systemic lupus erythematosus (SLE) patients, B cell abnormalities such as a lack of mitogen-responsive B cells and a predominance of spontaneous IgA-secreting ... See full document
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Original Article Correlation of latent membrane protein (LMP)-1, LMP-2A and early antigen B-cell epitope peptides of Epstein-Barr virus with risk and disease conditions of systemic lupus erythematosus
... SLE patients, no matter adults or pedi- atrics, are EBV seropositive ...autoreactive B-cells, T-cells and NK cells; (2) exacerbated inflammation by in- nate immune responses; (3) acti- ... See full document
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IL-22 production of effector CD4+ T-cells is altered in SLE patients
... Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown ...T-cell-dependent B-cell hyperactivity contributes to the inflammatory pathology of SLE ...and B-cells ... See full document
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Genetic contribution to mesenchymal stem cell dysfunction in systemic lupus erythematosus
... NZM2410 lupus susceptibility locus Sle1a1, with a deletion of DNA binding exon 6 and Hox binding exon 7 ...stem cells and blocks lineage-specific differentiation ...T cells and increased ... See full document
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Flow cytometric assessment of the signaling status of human B lymphocytes from normal and autoimmune individuals
... individual cells has now made it possible to delineate the perturbations that are present in lymphocytes from patients with autoimmune ...human B cells from the Ramos B ... See full document
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SYSTEMIC LUPUS ERYTHEMATOSUS
... Dermatologic symptoms are present in approximately 70-80%of SLE patients. The most characteristic skin lesion is the butterfly rash. The rash usually affects the checks bilaterally involves the bridge of nose and ... See full document
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Failure to achieve lupus low disease activity state (LLDAS) six months after diagnosis is associated with early damage accrual in Caucasian patients with systemic lupus erythematosus
... Retrospective analysis of prospectively collected data was performed, reviewing medical records and clinical files. Baseline was fixed at the time of diagnosis, which corresponded to treatment initiation (T0). No ... See full document
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A study of ocular manifestations of systemic lupus erythematosus
... pathognomonic lupus or butterfly rash across the nose and cheeks occurs in some 30% of patients with systemic lupus ...in systemic lupus erythematosus and discoid ... See full document
109
Oligonucleotide linked to human gammaglobulin specifically diminishes anti DNA antibody formation in cultured lymphoid cells from patients with systemic lupus erythematosus
... obtained from 87 patients with SLE, 55 of whom spontaneously produced anti-DNA antibodies in ...to antigen challenge in ...55 patients' PBL and abrogated the in vitro-induced response in all ... See full document
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Cathepsin G and Its Role in Inflammation and Autoimmune Diseases
... Roles of cathepsin G in vasculaR peRmeability Cathepsin G affects the cell shapes and causes the formation of intercellular gap in the endothelial cells and epithelial cells, which can increase their ... See full document
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Involvement of TLR7 MyD88 dependent signaling pathway in the pathogenesis of adult onset Still's disease
... IL-1 b levels (up to around 22-fold), IL-6 (up to around 28-fold), IL-18 (up to around15-fold), and IFN-a (up to around 17-fold) in AOSD patients compared to those in healthy controls, indicating that the ... See full document
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Circulating Immune Complexes in the Serum in Systemic Lupus Erythematosus and in Carriers of Hepatitis B Antigen QUANTITATION BY BINDING TO RADIOLABELED Clq
... large antigen excess (Ag 2 Ab) can still be detected by this radiolabeled C1q binding ...of antigen-F(ab¢) 2 antibody complexes to lead to a precipitation of [ 125 I]C1q in ... See full document
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Mortality Patterns in Malaysian Systemic Lupus Erythematosus Patients
... Mortality Patterns in Malaysian Systemic Lupus Erythematosus Patients ORIGINAL ARTICLE Mortality Patterns in Malaysian Systemic Lupus Erythematosus Patient~ S S Yeap, MRCP*, S K Chow, MRCP*, M Manivas[.] ... See full document
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Role of endoplasmic reticulum stress in the protective effects of PPARβ/δ activation on endothelial dysfunction induced by plasma from patients with lupus
... endothelial cells (HUVECs) incubated in plasma from patients with systemic lupus erythematosus (SLE) with active nephritis (AN) or healthy controls (Ctrol), or in plasma ... See full document
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Phytohemagglutinin Response in Systemic Lupus Erythematosus: RECONSTITUTION EXPERIMENTS USING HIGHLY PURIFIED LYMPHOCYTE SUBPOPULATIONS AND MONOCYTES
... hypocomplementemic lupus patients and in ...of lupus macrophages was similar to normals when allogeneic normal plasma was used in the culture ...became abnormal in the presence of SLE ...of ... See full document
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Genomic alterations in abnormal neutrophils isolated from adult patients with systemic lupus erythematosus
... Cytogenetic microarray analysis was performed by the Cytogenetics and Chromosomal Microarray core at the Fox Chase Cancer Center, using the Affymetrix 2.7 M Cytogenetics array chip, and genomic alterations were ... See full document
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SYSTEMIC LUPUS ERYTHOMATOUS - A CASE STUDY IN AYURVEDIC SETTING .......
... SLE is autoimmune diseases in which organs and cells undergo damage mediated by tissue binding auto antibodies and im- mune complexes. 1 SLE affects 2 to 8 per- sons per 100,000 in United States. Most cases ... See full document
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