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[PDF] Top 20 PD-L1 expression in papillary renal cell carcinoma

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PD-L1 expression in papillary renal cell carcinoma

PD-L1 expression in papillary renal cell carcinoma

... the PD-L1 staining patterns into three scores according to the percentage of PD-L1-positive cancer cells: score 0, negative or less than 2%; score 1, 2 to 30%; and score 2, more than 30% ... See full document

6

Basal cell carcinoma: PD-L1/PD-1 checkpoint expression and tumor regression after PD-1 blockade

Basal cell carcinoma: PD-L1/PD-1 checkpoint expression and tumor regression after PD-1 blockade

... basal cell carcinoma, however, has largely gone untested. Because PD-Ligand-1 (PD-L1) expression in other tumor types has been associated with response to anti-PD-1, we ... See full document

5

Biomarkers of immunotherapy in urothelial and renal cell carcinoma: PD-L1, tumor mutational burden, and beyond

Biomarkers of immunotherapy in urothelial and renal cell carcinoma: PD-L1, tumor mutational burden, and beyond

... to PD-L1 blockade required specific Bacter- oides - mice which were given oral Bifidobacterium improved tumor control to the same degree as those given an anti-PD-L1 agent ... See full document

10

<p>Mismatch repair status and high expression of PD-L1 in nasopharyngeal carcinoma</p>

<p>Mismatch repair status and high expression of PD-L1 in nasopharyngeal carcinoma</p>

... and PD-L1 expression in nasopha- ryngeal carcinoma (NPC), and investigate whether PD-L1 and MMR status could be used as a biomarker for predicting response of immune checkpoint ... See full document

10

Hereditary papillary renal cell carcinoma primarily diagnosed in a cervical lymph node: a case report of a 30-year-old woman with multiple metastases

Hereditary papillary renal cell carcinoma primarily diagnosed in a cervical lymph node: a case report of a 30-year-old woman with multiple metastases

... and renal cell carcinoma (HLRCC; MIM# 150800), which is characterized by papillary RCC type II with a worse prog- nosis as well as typically cutaneous and uterine leiomyo- mas ... See full document

5

Somatic mutations in renal cell carcinomas from Chinese patients revealed by whole exome sequencing

Somatic mutations in renal cell carcinomas from Chinese patients revealed by whole exome sequencing

... Membranous PD-L1 expression was positive in tumor cells from 6/26 (23%) RCC ...The PD-L1-positive rate was higher in RCC samples with the somatically mutated genes CSPG4, DNAH11, INADL ... See full document

12

Near complete response to Pembrolizumab in microsatellite-stable metastatic sebaceous carcinoma

Near complete response to Pembrolizumab in microsatellite-stable metastatic sebaceous carcinoma

... sebaceous carcinoma with metastases to brain, lungs, liver, bowel, lymph nodes, and ...strong PD-L1 expression he resumed pembrolizumab therapy and showed radiographic evidence of an ongoing ... See full document

7

Elevated PD-L1 expression predicts poor survival outcomes in patients with cervical cancer

Elevated PD-L1 expression predicts poor survival outcomes in patients with cervical cancer

... This meta-analysis was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Anal- yses (PRISMA) Statement [16]. Relevant studies were searched from online databases PubMed, EMBASE, Web of ... See full document

9

&lt;p&gt;Prognostic and clinicopathological value of PD-L1 in colorectal cancer: a systematic review and meta-analysis&lt;/p&gt;

<p>Prognostic and clinicopathological value of PD-L1 in colorectal cancer: a systematic review and meta-analysis</p>

... 42 renal cell cancer, 43 lung cancer, 44 ...of PD-L1 overexpression and poor OS in CRCs (HR ...of PD-L1 had poorer overall survival ...support PD-L1 as an ... See full document

12

Original Article Expression of AKR1C3 in renal cell carcinoma, papillary urothelial carcinoma, and Wilms’ tumor

Original Article Expression of AKR1C3 in renal cell carcinoma, papillary urothelial carcinoma, and Wilms’ tumor

... with expression in Bowman’ capsule, the mesangial cells, proximal and distal tubules, as well as mature urothelial ...the renal tubules for normal function in mature ...widespread expression of ... See full document

9

The Expression of Programmed Death Ligand-1 within Stages of Oral Squamous Cell Carcinoma: Immunohistochemical Analysis

The Expression of Programmed Death Ligand-1 within Stages of Oral Squamous Cell Carcinoma: Immunohistochemical Analysis

... of PD-L1 consisting of a larger sample size and inclusion of a control group would have provided an opportunity to determine and compare the role of PD-L1 in progression of a dysplastic lesion ... See full document

10

EZH2 negatively regulates PD-L1 expression in hepatocellular carcinoma

EZH2 negatively regulates PD-L1 expression in hepatocellular carcinoma

... Next, dual-luciferase reporter assays were performed to examine the effect of IRF1 on the transcriptional ac- tivity of CD274 promoter. The results showed that the luciferase activity of P1 promoter was enhanced by ... See full document

15

Cytomembranic PD-L1 expression in locoregionally advanced nasopharyngeal carcinoma

Cytomembranic PD-L1 expression in locoregionally advanced nasopharyngeal carcinoma

... nancy or other concomitant malignant disease; and 5) PD-L1 staining was detectable in the tumor cells. Therefore, there were 85 patients who qualified for this study. All patients underwent disease staging ... See full document

5

Nivolumab vs investigator&#039;s choice in recurrent or metastatic squamous cell carcinoma of the head and neck: 2-year long-term survival update of CheckMate 141 with analyses by tumor PD-L1 expression.

Nivolumab vs investigator's choice in recurrent or metastatic squamous cell carcinoma of the head and neck: 2-year long-term survival update of CheckMate 141 with analyses by tumor PD-L1 expression.

... across PD-L1 expressors/non-expressors in this patient ...between PD-L1 expressors and non-expressors. Among PD-L1 expressors, OS benefit vs IC was observed at the primary ... See full document

32

Original Article Exosomes derived from hepatocellular carcinoma inhibit CD4 and CD8 T cell function through the PD-1/PD-L1 pathway

Original Article Exosomes derived from hepatocellular carcinoma inhibit CD4 and CD8 T cell function through the PD-1/PD-L1 pathway

... [32] Gabrusiewicz K, Li X, Wei J, Hashimoto Y, Mari- setty AL, Ott M, Wang F, Hawke D, Yu J, Healy LM, Hossain A, Akers JC, Maiti SN, Yamashita S, Shimizu Y, Dunner K, Zal MA, Burks JK, Gu- min J, Nwajei F, Rezavanian A, ... See full document

8

Checkpoint molecule PD-1-assisted CD8&lt;sup&gt;+&lt;/sup&gt; T lymphocyte count in tumor microenvironment predicts overall survival of patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitors

Checkpoint molecule PD-1-assisted CD8<sup>+</sup> T lymphocyte count in tumor microenvironment predicts overall survival of patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitors

... cells PD-L1, were independent prognostic factors (training set [HR ...the PD-1 high/ CD8 low group had shorter survival (16 months) than PD-1 low/CD8 high group (51 months, P< ...Metastatic ... See full document

13

Original Article VEGF/VEGFR2 and PDGF-B/PDGFR-β expression in non-metastatic renal cell carcinoma: a retrospective study in 1,091 consecutive patients

Original Article VEGF/VEGFR2 and PDGF-B/PDGFR-β expression in non-metastatic renal cell carcinoma: a retrospective study in 1,091 consecutive patients

... in papillary type 1 than in clear cell RCC (Table 2), although their mean tumour sizes were similar ...with papillary type 2 RCC included a higher percentage of patients with T3 or higher stage, the ... See full document

9

PD-L1 expression correlated with p53 expression in oral squamous cell carcinoma

PD-L1 expression correlated with p53 expression in oral squamous cell carcinoma

... Furthermore, based on the results of Cancer Genome Atlas exome data analysis, there is a link between P53 status and mutation burden in tumors [18]. That is to say that the evaluation of P53 status could be used as a ... See full document

6

Cell death-related molecules and biomarkers for renal cell carcinoma targeted therapy

Cell death-related molecules and biomarkers for renal cell carcinoma targeted therapy

... : renal cell carcinoma; ccRCC : clear cell renal cell carcinoma; mRCC : metastatic renal cell carcinoma; pRCC : papillary renal ... See full document

15

Predictive role of PD-L1 expression in the response of renal Medullary carcinoma to PD-1 inhibition

Predictive role of PD-L1 expression in the response of renal Medullary carcinoma to PD-1 inhibition

... a PD-L1 inhibitor, has been effective against various malignancies in pre- clinical studies and clinical trials with a relatively favor- able toxicity ...advanced renal cell carcinoma ... See full document

6

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