[PDF] Top 20 Persistence of Antibody to Influenza A/H5N1 Vaccine Virus: Impact of AS03 Adjuvant
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Persistence of Antibody to Influenza A/H5N1 Vaccine Virus: Impact of AS03 Adjuvant
... nonadjuvanted vaccine and then ran- domized into 1 of 3 groups (1:1:1) to receive 2 intramuscular doses of vaccine containing ...monovalent vaccine was manufactured by Sanofi Pasteur, ...2.1.3.2 ... See full document
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Effect on Cellular and Humoral Immune Responses of the AS03 Adjuvant System in an A/H1N1/2009 Influenza Virus Vaccine Administered to Adults during Two Randomized Controlled Trials
... HI antibody response in subjects who had previously received seasonal ...seasonal influenza vaccina- tion was associated with a lower HI GMT after a first dose of nonadjuvanted A/H1N1/2009 ...seasonal ... See full document
9
Long-Term Persistence of Cell-Mediated and Humoral Responses to A(H1N1)pdm09 Influenza Virus Vaccines and the Role of the AS03 Adjuvant System in Adults during Two Randomized Controlled Trials
... HI antibody and CD4 ⫹ T-cell responses elicited by two doses of AS03-adjuvanted or nonadjuvanted A(H1N1)pdm09 influenza vaccine up to day 42 in two populations of adults ⱕ 60 years of age ...long-term ... See full document
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An Adjuvant for the Induction of Potent, Protective Humoral Responses to an H5N1 Influenza Virus Vaccine with Antigen-Sparing Effect in Mice
... good adjuvant (24, ...IgA antibody (1, ...external adjuvant, such as PIKA, allows IgA-secreting antibody secretory cells (ASCs) to be established more readily in the respiratory tract; we have ... See full document
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A DNA Vaccine-Encoded Nucleoprotein of Influenza Virus Fails To Induce Cellular Immune Responses in a Diabetic Mouse Model
... lethal influenza pandemics, such as that of avian-flu A/H5N1 virus, it is evident that new vaccines are needed to ensure optimal protection against all strains of influenza viruses (18, ...of ... See full document
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An Anti-H5N1 Influenza Virus FcDART Antibody Is a Highly Efficacious Therapeutic Agent and Prophylactic against H5N1 Influenza Virus Infection
... vanted H5N1 vaccines, it is likely that a matched vaccine will not be available until at least 6 months after the emergence of a pan- ...matched vaccine, nonpharmaceutical interventions, and ... See full document
13
Comparison of a novel microcrystalline tyrosine adjuvant with aluminium hydroxide for enhancing vaccination against seasonal influenza
... an adjuvant to an existing vaccine, as has been done for influenza [18, 41 – 43], represents a potential and substantial benefit, where seroconversion rates and protective antibody titres in ... See full document
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Usefulness of health registries when estimating vaccine effectiveness during the influenza A(H1N1)pdm09 pandemic in Norway
... against influenza A (H1N1)pdm09 started in Norway with vaccine available from GlaxoSmithKline Biologicals ...GSK’s AS03-adjuvanted monovalent vaccine containing ...The vaccine contained ... See full document
6
Neuraminidase-Inhibiting Antibody Is a Correlate of Cross-Protection against Lethal H5N1 Influenza Virus in Ferrets Immunized with Seasonal Influenza Vaccine
... H3N1 vaccine represented a subimmunogenic dose, with a possible ex- ception in one ...the vaccine (Fig. 3, open FIG 2 Response of ferrets to H5N1 challenge after vaccination with monovalent split or ... See full document
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Assessment of Antigen-Specific and Cross-Reactive Antibody Responses to an MF59-Adjuvanted A/H5N1 Prepandemic Influenza Vaccine in Adult and Elderly Subjects
... A/H5N1 influenza pandemic requires well-tolerated, effective vaccines which provide both vaccine strain-specific and heterologous, cross-clade ...prepandemic influenza vaccine ... See full document
6
H5N1-SeroDetect EIA and Rapid Test: a Novel Differential Diagnostic Assay for Serodiagnosis of H5N1 Infections and Surveillance
... against H5N1 viruses has been described elsewhere ...monoclonal antibody (5F8) targeting a short sequence in HA2 (aa 274 to 281) and has low H5N1 specificity, as some samples from seasonal ... See full document
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Qualification of the Hemagglutination Inhibition Assay in Support of Pandemic Influenza Vaccine Licensure
... (i) Precision testing. Precision testing was designed to determine the variabil- ity, or reproducibility, within an assay by a single operator on the same day and variability for that same operator over multiple days. A ... See full document
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The creation of a contagious H5N1 influenza virus: implications for the education of life scientists
... So it is against that background of widespread ignorance of, and opposition to, biosecurity con- siderations that current concerns about H5N1 have to be understood. And this is so even though in the years after ... See full document
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Assessment of Route of Administration and Dose Escalation for an Adenovirus-Based Influenza A Virus (H5N1) Vaccine in Chickens
... adenovirus-based vaccine, we failed to consistently detect an HI titer in the hatched chickens after egg injection of high doses of ...the vaccine is applied but also on the timing of the injection in ... See full document
6
Immunological adjuvant effect of the peptide fraction from the larvae of Musca domestica
... The cellular immune response plays an important role in the generation of both humoral and cell-mediated responses to vaccination. The mobilized T lymphocytes proliferate to protect the body by activating other immune ... See full document
9
Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus
... broad-spectrum H5N1 neutralizing antibodies. Intriguingly, the antibody loses its neutralization activity against other H5N1 genetic derivatives, such as H5N6 and H5N8, which emerged in recent years, ... See full document
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A Single-Cycle Vaccine Vector Based on Vesicular Stomatitis Virus Can Induce Immune Responses Comparable to Those Generated by a Replication-Competent Vector
... We have noted a consistent trend (although not statistically significant) in our data (Fig. 3; Table 1) that the cellular im- mune responses to HIV Env generated by the single-cycle VSV ⌬ G-EnvG vector were typically ... See full document
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A Duck Enteritis Virus-Vectored Bivalent Live Vaccine Provides Fast and Complete Protection against H5N1 Avian Influenza Virus Infection in Ducks
... DEV vaccine strain was prop- agated in CEFs and then purified by using 20 to 60% sucrose density gradient ...purified virus as described previ- ously (24) and was used to construct the DEV fosmid library ... See full document
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Development and persistence of local and systemic antibody responses in adults given live attenuated or inactivated influenza A virus vaccine
... The present study is the first to evaluate the magnitude and duration of the serum and nasal-wash immunoglobulin A IgA, IgG, and IgM HA antibody responses evoked by vaccination with live[r] ... See full document
7
Cardiac filariosis in migratory Mute swans (Cygnus olor) in Sicily
... emotional impact due to avian influenza risk and the outbreaks registered in wild species caused by virus H5N1-HPAI (High Pathogenicity Strain Avian Influenza), has stressed the ... See full document
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