[PDF] Top 20 The perturbation of thrombin binding to human platelets by anions
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The perturbation of thrombin binding to human platelets by anions
... washed human platelets. We present experiments indicating that thrombin binding correlates withe the release reaction when binding is perturbed by ...of human ... See full document
7
Reduced thrombin binding and aggregation in Bernard Soulier platelets
... bind human thrombin. Thrombin binding studies in the high affinity range showed 1,500 sites for the Bernard-Soulier platelets as against 4,000 for normal ...for thrombin at the ... See full document
5
Interaction of von Willebrand factor with human platelets in the plasma milieu
... The binding of von Willebrand factor (vWf) to stimulated platelets in the plasma milieu was performed using a radiolabeled monoclonal antibody to ...the thrombin- and ADP/epinephrine-induced vWf ... See full document
9
Thromboxane insensitive dog platelets have impaired activation of phospholipase C due to receptor linked G protein dysfunction
... platelet thrombin receptors appear to activate PI-PLC via other unidentified G ...proteins. Platelets from most dogs are TXA2 insensitive (TXA2-); ...(TXA2+) platelets that are responsive to ...TXA2- ... See full document
12
Identification of the thrombin receptor on human platelets by chemical crosslinking
... inhibit thrombin binding to platelets, this was not confirmed by equilibrium binding studies in the presence of vWf and ...all thrombin concentrations binding occurs at the same ... See full document
8
Demonstration and characterization of specific binding sites for factor VIII/von Willebrand factor on human platelets
... platelets. Binding is ristocetin-dependent and increases in proportion to the concentration of ristocetin from ...mg/ml. Binding of 125I-FVIII/vWF to platelets can be competitively inhibited ... See full document
10
Platelets have more than one binding site for von Willebrand factor
... the binding of 125I-vWF to normal platelets stimulated by thrombin or a combination of ADP + EPI, but completely blocked ristocetin- induced ...binding. Binding induced by ... See full document
13
Studies of the seven transmembrane domain thrombin receptor on human platelets and megakaryocytic cells
... of thrombin in haemostasis, it is not surprising that there has been, and still is, a huge amount of research to try and identify specific thrombin ...archetypal thrombin inhibitor of this ...anion ... See full document
276
Protease activated receptors 1 and 4 mediate activation of human platelets by thrombin
... of human platelets by ...in human platelets but were readily detected in Dami ...in platelets must of course be inter- preted with ...in human platelets is concordant with ... See full document
10
Binding of the products of prothrombin activation to human platelets
... to human platelets was tested with 125-I-labeled protein ...of thrombin bound to platelets under conditions in which high affinity binding of thrombin was observed,nor did they ... See full document
6
Inhibition by human thrombomodulin of factor Xa mediated cleavage of prothrombin
... or platelets, calcium, and Factor ...of thrombin generation was not decreased excluding the possibility that the inhibition by thrombomodulin was secondary to the binding of small amounts of ... See full document
6
Thrombin induced exposure and prostacyclin inhibition of the receptor for factor VIII/von Willebrand factor on human platelets
... concentration-dependent binding of 125I-labeled F. VIIIVWF in a steady-state system. The binding induced by thrombin was specific because it was inhibited by a 100-fold molar excess of unlabeled ... See full document
12
Role of hypoxia on platelet function in patients with chronic obstructive pulmonary disease
... experiments. Thrombin was used on washed human platelets suspension and ADP on platelet rich plasma to show that there was raised light transmittance in the presence of platelet ...PAC-1 ... See full document
6
The Effect of Gnidilatimonoein from Daphne mucronata, on the Adhesive Property of Human Platelets
... activated platelets to these cells was than ...attached platelets compared to the 20% in the control ...attached platelets compared to the 20% of the untreated HL- 60 cells in the control ... See full document
5
Distinct platelet thromboxane A2/prostaglandin H2 receptor subtypes A radioligand binding study of human platelets
... platelet binding site by stable TXA2/PGH2 ...two binding sites; a high-affinity site with Kd of 234 +/- 103 pM, Bmax of ...Parallel binding studies using the TXA2/PGH2 receptor antagonist ... See full document
10
Selective release of archidonic acid from the phospholipids of human platelets in response to thrombin
... amongst human platelet fatty acids in that it is the precursor of prostaglandins and ...important. Human platelets have a mechanism for incorporating arachidonic acid from plasma into their ... See full document
7
The Effects of Thrombin on Adenyl Cyclase Activity and a Membrane Protein from Human Platelets
... intact platelets were incubated with ...sonicated platelets or isolated membranes were incubated with these concentrations of ...by thrombin. Prior incubation of platelets with dibutyryl ... See full document
9
Role of Platelet Fibrinogen in the Reactions of Platelets to Thrombin
... Effects of a-chymotrypsin on platelets* Ability to Aggregation Clottable by subsequent support clot a-Chymotrypsin retraction addition of protein concentration Serotonin following thromb[r] ... See full document
9
Effects of Thrombin on the Potassium and ATP Content of Platelets
... In six experiments, twice washed platelets from 3-ml portions of plateletrich plasma were incubated at 370 C in Trisbuffered saline containing radioactive potassium K42 in addition to st[r] ... See full document
8
Thrombin Induced Increase in Intracellular Cyclic 3′,5′ Adenosine Monophosphate in Human Platelets
... on platelets is to cause a decrease in intracellular cyclic 3¢,5¢-adenosine ...Washed human platelets or platelet-rich plasma were incubated at 37°C with human ... See full document
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