[PDF] Top 20 Pharmacogenetic analysis of cinacalcet response in secondary hyperparathyroidism patients

... Korean patients are relatively small for genetic association study and diverse ethnic factors could not be ...included patients were on either hemodialysis or peritoneal dialysis; the Kt/V(K urea × T d /V ... See full document

... enrolled patients who received at least one dose of any study treatment and had at least one intact PTH measurement after the study began but excluded those who did not meet any of the inclusion criteria or fell ... See full document

... the cinacalcet withdrawal cohort from July 2015 to July ...all patients included had no history of prior cinacalcet ...thirteen cinacalcet naïve dia- lysis patients from the historical ... See full document

... bias. Patients in the low-dose group were younger, had higher serum phosphate levels, and had better nutritional conditions com- pared to the ...the response rate for the cinacalcet ...of ... See full document

... measures analysis of variance followed by Tukey’s post hoc ...regression analysis was performed using %ACAI (month 24/month 36/ month - 12/0) = (ACAI [month 36]/ACAI [month 24])/(ACAI [month 0]/ACAI [month ... See full document

... of secondary hyperparathyroidism (2HPT) in the setting of chronic kidney disease-mineral bone disor- der (CKD-MBD), increases with dialysis vintage, and, prior to the calcimimetic era, parathyroidectomy ... See full document

... Although differential diagnoses for an isolated bone lesion are extensive, when confronted with a patient with CKF, an osseous mass and laboratory data that show increased levels of calcium, phosphate, phosphocalcic ... See full document

... We formed two subgroups based on the change in bone mineral density (BMD) values as a result of therapy. The group of responders included all those patients in whom BMD level decreased as compared to the baseline ... See full document

... true response to that ...a response phenotype is heritable can vary depending on which metric is ...a response measurement that is not heritable would plague any genetic study from the ...heritable ... See full document

... in patients with chronic kidney disease, where pos- ...in patients with moderate to severe and severe chronic kidney disease ...in patients with advanced CKD are limited, and studies investigating ... See full document

... five patients. For histological analysis, speci- mens were processed in formalin and embedded in paraffin; we performed hematoxylin and eosin (H&E) ...the analysis of tissues on images acquired ... See full document

... the hyperparathyroidism becomes uncontrolled, the parathyroidectomy remains the ...of hyperparathyroidism secondary to chronic renal failure in the Service of surgery B of the Central Hospital ... See full document

... 40 patients with idiopathic hypercalciuria (IH) before and during reversal of hypercalciuria with thiazide, and in four normal subjects before and during induction of hypercalciuria with ...26 patients with ... See full document

... Among patients with secondary hyperparathyroidism and normal renal function, iPTH was 3- to 8-fold elevated in those with.. rickets, and 1.3- to 2.0-fold above normal in those with.[r] ... See full document

... Furthermore, we investigated the role of preoperative vitamin D therapy on postoperative serum calcium levels, the duration of intravenous vitamin D supplementation, and the incidence of HBS. Regarding the risk for HBS, ... See full document

... This was a retrospective, observational, analytical study, which included patients who are followed at the clinic in Hospital Geral de Fortaleza, Brazil. A files review of the patients diagnosed with HIV ... See full document

... dialysis-dependent patients, one might hypothesize whether a dual therapy with an active vitamin D (calcitriol, alfacalcidol, or analogs) and a vitamin D prohomone could help to reduce the dose of the active ... See full document

... than those who had taken these medications for less than 2 years (32.87±11.00 ng/mL vs. 37.08±10.40 ng/mL; p=0.03). There was no difference in vitamin D levels between pa- tients receiving mono- and polytherapy ... See full document

... Immunocytochemical analyses were performed using the streptavidin-peroxidase method (UltraVision Plus Large Volume Detection System Anti-Polyvalent, HRP immunostaining Kit,Thermo Scientific, UK). Cultured cells were ... See full document

... Thirty-five SHPT patients receiving hemodialysis gave consent, of whom 29 were eligible for participation in the study. Preliminary screenings were conducted on patients who provided consent. The key ... See full document