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[PDF] Top 20 Pharmacogenomics: Applications in Drug Discovery and Pharmacotherapy

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Pharmacogenomics: Applications in Drug Discovery and Pharmacotherapy

Pharmacogenomics: Applications in Drug Discovery and Pharmacotherapy

... of drug on patient with its different ...the drug dose and regimen could be designed personally for the ...patient. Pharmacogenomics can be defined as the study of variation in DNA sequence and its ... See full document

14

Emerging strategies and applications of pharmacogenomics

Emerging strategies and applications of pharmacogenomics

... of pharmacogenomics is currently being applied throughout the drug discovery and development process, as depicted in Figure ...for discovery investment; the comprehensive evaluation of the ... See full document

12

Developments in renal pharmacogenomics and applications in chronic kidney disease

Developments in renal pharmacogenomics and applications in chronic kidney disease

... Abstract: Chronic kidney disease (CKD) has shown an increasing prevalence in the last century. CKD encompasses a poor prognosis related to a remarkable number of comorbidities, and many patients suffer from this disease ... See full document

16

Natural Product in Drug Discovery: Back to Future

Natural Product in Drug Discovery: Back to Future

... The drug discovery from natural source makes use of material that has been found by trial and error over many years in different cultures and systems of ... See full document

6

The science and engineering of stem cell–derived organoids-examples from hepatic, biliary, and pancreatic tissues

The science and engineering of stem cell–derived organoids-examples from hepatic, biliary, and pancreatic tissues

... As we have reviewed here, organoid engineering is an active area of recent research with a wide range of applications, ranging from disease modeling, drug discovery, cell cultiv[r] ... See full document

45

Human pluripotent stem cells as tools for high-throughput and high-content screening in drug discovery

Human pluripotent stem cells as tools for high-throughput and high-content screening in drug discovery

... in drug discovery is the lack of suitable models for sensitive, reliable, and rapid assessment of lead molecules in preclinical stages of drug ...modeling, drug discovery, and ... See full document

14

2012 highlights in translational 'omics

2012 highlights in translational 'omics

... goal of doctors since the Greek founders of medicine. In its modern form, personalized medicine is empowered by technological advances in experimental and compu­ tational platforms, triggering the transition from the ... See full document

5

Personalized antiplatelet and anticoagulation therapy: applications and significance of pharmacogenomics

Personalized antiplatelet and anticoagulation therapy: applications and significance of pharmacogenomics

... underlie drug response, we acknowledge the burgeoning field of other “omic” technologies (eg, transcriptomics, proteomics, and metabolomics) that are increasingly being used to character- ize drug ... See full document

19

A Facile Synthesis of 2 Amino 5 Cyano 4, 6 Disubstitutedpyrimidines under MWI

A Facile Synthesis of 2 Amino 5 Cyano 4, 6 Disubstitutedpyrimidines under MWI

... Microwave Assisted Organic Synthesis (MAOS) is energy efficient and effective tool to speed up the syn- thesis for drug discovery process. In the present study we report a novel protocol for the rapid, high ... See full document

6

Dynamic molecular control of nanoparticle building block assembly

Dynamic molecular control of nanoparticle building block assembly

... Dynamic covalent chemistry has attracted a large amount of interest and has found numerous applications in, for example, self-assembly, molecular recognition, drug discovery and systems [r] ... See full document

241

Pharmacogenomics and modern therapy

Pharmacogenomics and modern therapy

... and drug intersection of pharmaceuticals and ...terms pharmacogenomics and the basis of population averages, rather than individual pharmacogenetics is considered ... See full document

6

Toxins and drug discovery

Toxins and drug discovery

... In the last 30 years, the FDA has approved 1355 new drugs (Newman and Cragg, 2012) and 1453 in all years up to 2013 (Kinch et al., 2014). From the discussions above, it is clear that very few of these are toxins or are ... See full document

8

Drug discovery in jeopardy

Drug discovery in jeopardy

... companies. Reduced productivity in the drug industry is caused mainly by corporate policies that discourage innovation. This is compounded by various consequences of mega-mergers, the obsession for blockbuster ... See full document

7

Formulation Design and Pharmaceutical Considerations for Paediatric Patients: Current Status and Future Dimensions

Formulation Design and Pharmaceutical Considerations for Paediatric Patients: Current Status and Future Dimensions

... of drug in ...forms drug is mixed with waxy substances that liquefies when inserted into rectum because rectum’s wall is rich in blood supply through which the drug is absorbed ... See full document

6

Phytochemical and Pharmacological Assessment of Leucas Aspera (WILLD.) Link Whole Plant

Phytochemical and Pharmacological Assessment of Leucas Aspera (WILLD.) Link Whole Plant

... or crayfish. This name probably comes from the appearance of the cut surface of a solid malignant tumour, with a roundish hard centre surrounded by pointy projections, vaguely resembling the shape of a crab. He later ... See full document

83

Phytochemical Analysis and Pharmacological Screening of  
Quercus Infectoria

Phytochemical Analysis and Pharmacological Screening of Quercus Infectoria

... For drug-targeted bio prospecting an industrial partner is needed, which will be instrumental in converting the discovery into a commercial ...to discovery, on the sharing of benefits as part of the ... See full document

84

Pharmacist-managed clinics for patient education and counseling in Japan: current status and future perspectives

Pharmacist-managed clinics for patient education and counseling in Japan: current status and future perspectives

... about pharmacotherapy, and the outcome of treatment have been repeatedly reported in the United States, the evidence is limited in ...in pharmacotherapy management in PMC will be further appreciated by ... See full document

8

Pharmacogenomics of drug metabolizing enzymes and transporters: implications for cancer therapy

Pharmacogenomics of drug metabolizing enzymes and transporters: implications for cancer therapy

... results on the clinical impact of ABCB1 polymorphisms may reflect the complex disposition pathway of the substrate drugs. For example, the commonly used in-vivo ABCB1 probe drugs such as digoxin, fexofenadine, and ... See full document

23

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... Reports of hepatotoxic effects of diclofenac (36, 48, 49) have raised the question whether the gene variants CYP2C8*3, CYP2C9*2,*3 or UGT2B7*2, which code for low-activity enzymes, could worsen these effects. Aithal et ... See full document

8

Pharmacogenomics of adverse drug reactions

Pharmacogenomics of adverse drug reactions

... by drug discontinuation but can be more serious on rare occasions with a more severe form of disease resulting in rhabdomyolysis followed by possible death (for review, see ... See full document

12

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