[PDF] Top 20 Phylogenetic ctDNA analysis depicts early stage lung cancer evolution
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Phylogenetic ctDNA analysis depicts early stage lung cancer evolution
... C.A., N.J.B., G.A.W., M.J-H., T.C., R.S., and J.L-Q. contributed equally to this work. C.A. and C.S. co-wrote the manuscript. C.A., M.J.H., and C.S. conceived study design. C.A., N.J.B., G.A.W. and R.R. integrated ... See full document
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Predicting Relapse with Circulating Tumor DNA Analysis in Lung Cancer.
... of ctDNA analysis are in early stage cancer, detecting residual disease to predict who is at risk of relapse, and using ctDNA assays to screen for cancer in unaffected ... See full document
5
Identification of tumor-educated platelet biomarkers of non-small-cell lung cancer
... of lung cancer is critical for NSCLC patients, since early-stage patients have much longer survival than late-stage ...conventional lung cancer screening, such as chest ... See full document
9
Next-generation sequencing of circulating tumor DNA for detection of gene mutations in lung cancer: implications for precision treatment
... Background: Lung cancer remains a major global health problem, which causes millions of deaths ...the stage of lung cancer, precise early diagnosis is of great significance to ... See full document
6
Non-invasive diagnosis of early-stage lung cancer using high-throughput targeted DNA methylation sequencing of circulating tumor DNA (ctDNA)
... for lung cancer development ...facilitated ctDNA detection, among which nodule size is the strongest risk factor other than DNA methylation in predicting malignancy (Table S5 and Table ... See full document
15
ctDNA as a cancer biomarker: a broad overview
... The profile of mutations and the behavior of cancer cells change in a dynamic way and may show additional features over time (Brown et al., 2017; Kim et al., 2015; Zheng et al., 2018). Recurrence or metastases are ... See full document
30
Non-invasive urine testing of EGFR activating mutation and T790M resistance mutation in non-small cell lung cancer
... with cancer, plasma ctDNA contains genomic mutations that are concordant with the primary tumor and ctDNA has greater representation of muta- tion burden than single tissue biopsies ...Systemic ... See full document
6
<p>Role of surgery in patients with early stage small-cell lung cancer</p>
... with stage I SCLC. 22,23 A growing number of patients with early stage SCLC receive surgical treatment, resulting in a favorable overall median survival of 29 – 91 ...with early stage ... See full document
13
Forecasting of Survival Rate in Patients with the Early Stage of Non Small Cell Lung Cancer
... comorbidities, stage, type of resection, ...the lung, central/peripheral cancer), neoplasm size, neoplasm size (categorized index), “T” criterion, “N” criterion, stage of ...mor, stage, ... See full document
6
Situation of Lung Cancer among The Population of Mongolia
... of early detection program and development of comprehensive palliative care ...modern early detection and treatment method of lung cancer by cooperation with countries with advanced treatment ... See full document
7
Results from the national sepsis practice survey: predictions about mortality and morbidity and recommendations for limitation of care orders
... Predicted probability of baseline hospital mortality For all patients described in the vignettes, the median baseline mortality (the predicted hospital mortality if no additional ther- apies were added after ICU ... See full document
11
Tufman, Amanda (2013): IL-22 in lavage as a biomarker in patients with lung cancer. Dissertation, LMU München: Medizinische Fakultät
... otherwise early stage disease, and the observation that many of these patients do not go on to develop true clinically relevant metastatic disease despite having received only local therapy suggests that ... See full document
109
Unusual synchronous double primary treatment naïve lung adenocarcinoma harboring T790M and L858R mutations in early stage lung cancer
... lower lung and a faint nodular lesion over the left lower lung ...PCR analysis showed that the right-sided tumor had an epidermal growth factor receptor (EGFR) mutation presenting as point mutation ... See full document
6
<p>Comparative Effectiveness of Radiofrequency Ablation, Surgical Resection and Transplantation for Early Hepatocellular Carcinoma by Cancer Risk Groups: Results of Propensity Score-Weighted Analysis</p>
... Our study is not devoid of limitations. Firstly, our study is limited by the retrospective nature of the entire cohort. In order to overcome this lack, we applied PS score analysis and IVA analysis to ... See full document
12
Comparison of Stereotactic Body Radiotherapy Delivery Techniques for Early Stage Lung Cancer Using Lung Toxicity Modeling
... of lung cancer, normal lung toxicity is a primary concern for treatment complications ...conventional lung cancer RT, commonly used dosimetric quantities include the volume of the ... See full document
14
Phylogenetic analysis of the evolution of lactose digestion in adults
... There are three major hypotheses for the evolution of high adult LDC. The first hypothesis was independently proposed by Simoons (1969, 1970) and Mc- Cracken (1971). They observed that in regions where milk was ... See full document
24
Emerging therapies for non-small cell lung cancer
... The current standard first-line treatment for advanced non-small cell lung cancer harboring ALK rearrange- ment is crizotinib [89]. Despite the rapid response to cri- zotinib, most of the patients would ... See full document
24
Improving Detection Accuracy of Lung Cancer Serum Proteomic Profiling via Two-Stage Training Process
... 118 cancer patients (80 males and 38 females), histologic distribution were 27 squamous cell carcinomas, 71 adenocarcinomas, 9 small cell cancers, and 11 ...no cancer history or acute/chronic inflammatory ... See full document
10
Early ctDNA dynamics as a surrogate for progression-free survival in advanced breast cancer in the BEECH trial.
... this analysis as this gene is commonly mutated in breast cancer, despite also being CHIP associated (supple- mentary Figure S4, available at Annals of Oncology ... See full document
8
Real-world treatment patterns for patients 80 years and older with early lung cancer: a nationwide claims study
... with early-stage lung cancer between 2008 and 2016 in real practice in South ...for early-stage lung cancer is surgical resection with lobec- tomy ...non-operable ... See full document
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