[PDF] Top 20 PIG3 Functions in DNA Damage Response through Regulating DNA-PKcs Homeostasis
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PIG3 Functions in DNA Damage Response through Regulating DNA-PKcs Homeostasis
... The DNA double-strand break (DSB) is consid- ered to be the most severe type of DNA damage in- duced by ionizing radiation, and this form of DNA damage must be repaired immediately to ... See full document
10
Sirtuins and diabetes: optimizing the sweetness in the blood
... in response to calorie restriction and oxidative stress ...logical functions of Sirt4 includes secretion of insulin and metabolism by interacting with ...metabolic homeostasis by regulating ... See full document
8
TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1
... The DNA dependent protein kinase complex (DNA-PK) is a critical component of the NHEJ pathway, which consists of a Ku70/Ku80 heterodimer and the DNA dependent protein kinase catalytic subunit ... See full document
12
Temporal DNA-PK activation drives genomic instability and therapy resistance in glioma stem cells
... of DNA damage response enzymes, including DNA-PK, ATM, and ATR, has emerged as a crucial strategy for sensitizing tumor cells to radiotherapy and chemotherapy over last two decades ... See full document
17
DNA Damage Sensors ATM, ATR, DNA-PKcs, and PARP-1 Are Dispensable for Human Immunodeficiency Virus Type 1 Integration
... Viral DNA integration is an essential step in the retroviral life ...stranded DNA copy of the viral genomic ...initial DNA cutting and joining steps of the integration process are mediated by the ... See full document
6
A Synthetic Circuit For Control Of The Bacterial Dna Damage Response Without Dna Damage
... which DNA photoproducts may lead to cell death, and the timeframe in which DNA repair must occur for an adequate response, are incompletely ...UV-induced DNA damage from activation of ... See full document
135
The DNA damage response promotes polyomavirus JC infection by nucleus to cytoplasm NF kappaB activation
... JCV is a small DNA tumor virus belonging to the polyomavirus family that has a ~5.1 Kbp, circular, closed, supercoiled, double-stranded DNA genome. Both JCV and Polyomavirus BK (BKV), the causative agent of ... See full document
10
Identification of DNA-PKcs as a primary resistance factor of salinomycin in osteosarcoma cells
... including DNA-PKcs and the two Ku hetero- dimer (Ku-70 and Ku-80) [14, ...15]. DNA-PKcs is 460-kDa serine/threonine protein kinase that belongs to phosphatidylinositol 3-kinase (PI3K)-like ... See full document
11
DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway
... Mechanistic details of replication-dependent ICL re- pair emerged from studies in Xenopus egg extracts where replication-coupled ICL repair was reconstituted in vitro by using site-specific ICL templates [27]. When a ... See full document
10
The Smc complexes in DNA damage response
... in DNA repair is the repair of collapsed replication forks ...shaped DNA molecules at damaged replication forks [84], although the relevant substrate of Mms21 in this process is ...for DNA repair ... See full document
11
PRKDC mutations in a SCID patient with profound neurological abnormalities
... for DNA-PKcs for NHEJ in humans; (b) the clinical features arise from a non-NHEJ function of DNA-PKcs in humans, such as a role in telomere maintenance; or (c) there is a greater requirement ... See full document
13
<p>Digital Immune-Related Gene Expression Signatures In High-Grade Serous Ovarian Carcinoma: Developing Prediction Models For Platinum Response</p>
... these studies is the relatively small sample size used in the training cohort. Results of a complex fi eld as host ’ s anti-cancer immune response rendered on 24 subjects must be weighted carefully. We used this ... See full document
13
The role of Plk4 in DNA damage pathways and entry into mitosis.
... Cdc25C, Cyclin B l nuclear accumulation is also necessary for mitotic entry to occur. Interestingly, evidence indicates that the initial activation of the Cdkl/Cyclin B complex occurs at the centrosome (Jackman et al., ... See full document
80
Attenuation of DNA-dependent protein kinase activity and its catalytic subunit by the herpes simplex virus type 1 transactivator ICP0.
... of DNA-PK activity is an im- portant mechanism for increasing the levels of RNAP II tran- scription on viral DNA or on transfected ...DNA. DNA-PK is known to inhibit transcription by RNAP I ... See full document
7
Phosphatases in the cellular response to DNA damage
... of damage that is progressively amplified to relay the signal to a large number of sub- strates in the cell ...the damage by ATM ...the response depends on the activity of phosphatases in order to ... See full document
12
Functions of Saccharomyces cerevisiae 14-3-3 Proteins in Response to DNA Damage and to DNA Replication Stress
... Figure 7.—Recovery from HU arrest in bmh1 mu- tants. Strains were as fol- lows: wild type (wt; K699), bmh1⌬ (YLL138), bmh2⌬ (YLL908), bmh1-103 bmh2⌬ (YLL1082), bmh1-167 bmh2⌬ (YLL1083), bmh1-221 bmh2⌬ (YLL1081), bmh1-42 ... See full document
16
checkpoint following DNA damage by doxorubicin during transient mitotic arrest
... but DNA damage can cause genomic instability by inducing mutations within chromosomal ...against DNA damage. During the checkpoint process, cells recognize DNA damage and stop ... See full document
12
Original Article Prognostic significance of DNA-dependent protein kinase catalytic subunits in patients with nasopharyngeal carcinoma
... of DNA-PKcs on prognosis may derive from the association between DNA-PKcs and lymph node ...of DNA- PKcs tended to have a higher rate of neck lymph node metastasis than those ... See full document
10
Functions of DNA Damage Response Factors in Lymphocyte Development and Transformation
... bind DNA and form a large protein complexe that can accommodate and shepherd the DSB intermediates during the joining ...and DNA-PK, and together form a larger complex to tether cleavage DNA ends and ... See full document
198
Spy1 Regulation of the DNA Damage Response; Checkpoint Activation and Cellular Senescence
... replicated DNA to the next ...mostly through the inhibition of the kinase activity of Chk1 towards Cdc25C ...Cdk1 through removal of inhibitory phosphorylation of the threonine 14 and tyrosine 15 ... See full document
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