[PDF] Top 20 PKC θ knockout mice are protected from fat induced insulin resistance
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PKC θ knockout mice are protected from fat induced insulin resistance
... transgenic mice with muscle-specific expression of dominant- negative PKC-θ showed age-associated increases in adiposity, fasting and fed insulin levels, blunted results of glucose and ... See full document
6
Inactivation of fatty acid transport protein 1 prevents fat induced insulin resistance in skeletal muscle
... protection from fat- induced defects in insulin signaling activities and insulin action in skeletal ...that fat-induced insulin resistance in skeletal muscle ... See full document
9
MGAT2 deficiency ameliorates high-fat diet-induced obesity and insulin resistance by inhibiting intestinal fat absorption in mice
... oral fat tolerance test (OFTT), Mgat2-deficient mice absorbed less fat into the ...Mgat2-deficient mice were protected from HFD-induced obesity and insulin ...) ... See full document
10
Hyposialylated IgG activates endothelial IgG receptor FcγRIIB to promote obesity induced insulin resistance
... muscle insulin delivery (10). Insulin delivery and par- ticipation in skeletal muscle glucose metabolism are intricately influenced by processes occurring in the muscle microvasculature ...endothelium, ... See full document
15
Palmitic acid mediates hypothalamic insulin resistance by altering PKC θ subcellular localization in rodents
... of PKC in peripheral ...isoform, PKC-q, was expressed in critical CNS regions that regulate energy balance and whether it mediated the deleterious effects of diets high in fat, specifically palmitic ... See full document
14
Taubes - 2009 - Prosperitys Plague.pdfView Download
... that insulin resistance can be induced in lean strains of mice by overexpressing NF- κ B in their fat or liver cells and that obese mice can be protected from ... See full document
6
The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice
... null mice to develop obesity and/or insulin resistance (Table ...null mice become more glucose intolerant, whereas Scd1 and Srebp1c null mice are protected against these ... See full document
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Prevention of fat induced insulin resistance by salicylate
... muscle insulin signaling may involve increases in intracellular fatty acid derived metabolites ...(e.g., PKC-θ, IKK- β ...of PKC- θ ...of PKC-θ, which was associated with ... See full document
11
Correlation between brain neurotransmitters and insulin sensitivity: Neuro-preservative role of resveratrol against high fat, high fructose-induced insulin resistance
... in fat and fructose triggers the explosion of free radicals and depletion of the antioxidant levels, thereby generating a redox imbalance, thus resulting in oxidative and nitrosative stresses in all body organs ... See full document
11
Does elevated bilirubin aid weight control by preventing development of hypothalamic leptin resistance?
... body fat, body weight, waist circumference and BMI in overweight subjects placed on a calorie-re- stricted diet; reductions in triglycerides and C reactive protein were also greater in the spirulina ... See full document
7
PKCλ regulates glucose induced insulin secretion through modulation of gene expression in pancreatic β cells
... HNF3β (Foxa-2) is a member of the hepatocyte nuclear factor 3 and forkhead family of transcription factors that also includes HNF3α (Foxa-1) and HNF3γ (Foxa-3). HNF3 proteins play important roles in maintaining glucose ... See full document
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Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation
... Insulin resistance markedly increases cardiovascular disease risk in people with normal glucose tolerance, even after adjustment for known risk factors such as LDL, triglycerides, HDL, and systolic blood ... See full document
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Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARγ
... Insulin resistance is the chief abnormality present in metabolic syndrome, a complex physiological condition in which obesity, hypertension, dyslipidemia, and diabetes mellitus coexist in a single ... See full document
11
Coffee intake mitigated inflammation and obesity-induced insulin resistance in skeletal muscle of high-fat diet-induced obese mice
... C57BL6J mice obtained from Charles River Japan (Tokyo) were housed individually in animal cages in a room with controlled temperature (23 ± 2 °C), humidity (50 ± 10 %), and lighting (lights on from ... See full document
10
c Jun N terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
... Western blot analysis. Synoviocytes were pretreated with medium or MAPK inhibitors for 30 minutes and fur- ther incubated with IL-1 (2 ng/ml) for 15 minutes. Pro- tein samples (25 µg/lane) from FLS were run on a ... See full document
10
Enhanced susceptibility of cyclin kinase inhibitor p21 knockout mice to high fat diet induced atherosclerosis
... the extent to which developing atherosclerotic lesions are stabilized by a collagen-rich fibrous cap and higher levels of TGF-β in SMC of stable lesions compared to the unsta- ble lesions were observed [14]. These ... See full document
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Ablation of AMP-Activated Protein Kinase \(\alpha\)2 Activity Exacerbates Insulin Resistance Induced by High-Fat Feeding of Mice
... TG mice was due to defects in insulin secretion or hepatic glucose production, this seems unlikely because the ablation of AMPK ␣ 2 activity blunted insulin-stimulated glucose trans- port measured in ... See full document
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Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
... High-fat diet shifts the intracellular redox environment to a more oxidized state in skeletal muscle. (A and B) SS31 prevents the increase in GSSG and decrease in GSH/GSSG ratio in response to acute glucose ... See full document
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Loss-of-function phenotype of a PKCθT219A knockin mouse strain
... Nuclear extracts were harvested from 1 × 10 7 cells ac- cording to standard protocols. Briefly, activated CD4 + T cells were harvested and washed in PBS and resuspended in 10 mM HEPES (pH 7.9) 10 mM KCl, 0.1 mM ... See full document
11
Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice
... to insulin resistance and diabetes in humans, but also because Notch1 expres- sion in the subcutaneous adipose tissue of HIV-positive patients treated with antiretrovirals is increased (12) (Supplemental ... See full document
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