[PDF] Top 20 Plasma exosome microRNAs are indicative of breast cancer

... Background: microRNAs are promising candidate breast cancer biomarkers due to their cancer-specific expression ...circulating breast cancer biomarkers are challenged by the ... See full document

... lung cancer cell proliferation and migration via the TGFβRII/ERK pathway, which is indicative of a novel therapy of lung ...to cancer tissues in ...EGFR-expressing breast cancer tissue ... See full document

... as breast tumor biomarkers are centered largely on their non-invasive finding in serum and plasma and on their strong confrontation and steadiness under problematic environmental ...for breast tumor ... See full document

... be indicative of tumour subtype or aid selection of optimal treatment strategies will be key to successful implementation in the clinical ...early breast cancer ... See full document

... in breast cancer cell-secreted exosomes and to investigate the potential of these miRNAs to function as circulating biomarkers for breast ...between exosome- encapsulated miRNAs that were ... See full document

... Circulating miRNAs are protected from ribonuclease degradation by assembly into microvesicles and exosomes. Releasing miRNAs completely from these particles is the key step to quantify the circulating miRNAs. Currently ... See full document

... measure plasma miRNAs without RNA ...metastatic breast cancer patients, indicating miR-106a are a potential biomarker for metastatic breast ... See full document

... the microRNAs in secreted exosomes can be trans- ferred to a recipient cell where they affect post-transcriptional gene regulation and regu- late proliferation, migration, and invasiveness in cancer ... See full document

... showed microRNAs (miRNAs) in plasma are potential biomarkers for colorectal cancer ...for breast cancer ...corresponding plasma from breast cancer patients, and ... See full document

... as breast and prostate cancer 57,58 and it has been shown as a miRNA target in breast cancer cells and primary prostatic epithelial cells 56 ...prostate cancer cell lines and clinical ... See full document

... Conclusions Our results suggest that dormancy and metastasis-related miRNAs are differentially expressed in plasma in patients with early breast cancer who experience disease recur- rence and in ... See full document

... CIRCULATING MICRORNAs AS EARLY DETECTION MARKERS FOR BREAST CANCER Despite improvements in screening techniques and treatment strategies, breast cancer is still one of the leading ... See full document

... in breast cancer breast cancer is the most common cancer in women ...of breast cancer and prolonged patient survival, but they are known to have some limitations for early ... See full document

... of exosome isolation, although similar observa- tions have been made in a clinical setting ...allow exosome isolation and detection from as little as 10 μL of conditioned media (data not ...[5], ... See full document

... of breast CSCs can promote the aggressiveness of cancer cells through nearby immune cells via interaction with toll-like receptors to up-regulate secretion of TNF α and IL-6 ...of breast CSCs which ... See full document

... lung cancer risk in passive smokers using salivary exosome-derived microRNAs ...isolated exosome and washed and spun repeatedly using a filter cartridge to obtain the total ...lung ... See full document

... without breast cancer is therefore of crucial impor- tance in early cancer detection, to improve disease free and overall survival from the ... See full document

... of breast cancer that has limited treatment options ...triple-negative breast cancer but its clinical significance is still unclear [14, ... See full document

... including breast cancer [44,45], and to promote metastasis of tumor cells in a mouse xenograft model ...human breast cancer tissues showing that a decrease in miRNA-200 family miRNAs was ... See full document

... for breast cancer patients, we investigated the effect of high expression of predicted miR-296-5p target genes in basal breast ...human cancer, comprising HMGA1, MMP1, MAP2K3, SCRIB, PUMA, ... See full document