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[PDF] Top 20 Pleomorphism and drug resistant cancer stem cells are characteristic of aggressive primary meningioma cell lines

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Pleomorphism and drug resistant cancer stem cells are characteristic of aggressive primary meningioma cell lines

Pleomorphism and drug resistant cancer stem cells are characteristic of aggressive primary meningioma cell lines

... for stem cell markers, however, NG cell lines showed increased number of CD133+ Sox2+ and AGR2+ BMI1+ co-positive ...NG cell lines are important for tumor dynamic growth and ... See full document

14

MRP1-CD28 bi-specific oligonucleotide aptamers: target costimulation to drug-resistant melanoma cancer stem cells

MRP1-CD28 bi-specific oligonucleotide aptamers: target costimulation to drug-resistant melanoma cancer stem cells

... tumors. Cancer immunotherapy has emerged with strength within the arsenal of therapeutic strategies in oncology upon the success of recent clinical ...and cell differentiation into effector T cells ... See full document

15

Comparative profiling between primary colorectal carcinomas and metastases identifies heterogeneity on drug resistance

Comparative profiling between primary colorectal carcinomas and metastases identifies heterogeneity on drug resistance

... on drug resistance and its underlying mechanism between metastatic and primary ...of cancer stem cells (CSCs) and drug resistance relative proteins between lymph-node metastatic ... See full document

13

Cancer death rates   necessitates a need for natural medicine

Cancer death rates necessitates a need for natural medicine

... chemotherapeutic drug used to treat solid and hematopoietic ...to cell membranes (Mordente et ...small cell lung cancer, pancreas, bladder, over and breast ... See full document

10

5-Fluorouracil Chemotherapy of Gastric Cancer Generates Residual Cells with Properties of Cancer Stem Cells

5-Fluorouracil Chemotherapy of Gastric Cancer Generates Residual Cells with Properties of Cancer Stem Cells

... patient-derived cells to imatinib resulted in the enrichment of a qui- escent CD34+ population [24]; similar results were observed in an independent study by Jorgensen et ...CML cells were sensitized to ... See full document

11

Critical role of androgen receptor level in prostate cancer cell resistance to new generation antiandrogen enzalutamide

Critical role of androgen receptor level in prostate cancer cell resistance to new generation antiandrogen enzalutamide

... enzalutamide resistant cell lines with other drugs that target the AR pathway, such as bicalutamide or ...enzalutamide resistant PC346C cells to abiraterone has been reported in 2013 ... See full document

14

Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells

Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells

... melanoma cells to chemo- therapeutic agents, we tested three different classes of DNA damaging agents: carmustine, cisplatin and DTIC in 9 NRAS mutant and 9 BRAF mutant melanoma cell lines (mutNRAS ... See full document

13

Stem cells: a model for screening, discovery and development of drugs

Stem cells: a model for screening, discovery and development of drugs

... conclusion, stem cells (both normal and cancerous) are a valuable tool in the drug discovery ...tumorigenic stem cell behavior (Figure ...embryonic stem cells are limited ... See full document

9

Patterns of cancer cell sphere formation in primary cultures of human oral tongue squamous cell carcinoma and neck nodes

Patterns of cancer cell sphere formation in primary cultures of human oral tongue squamous cell carcinoma and neck nodes

... temperature (RT), washed in distilled water (DW), treated with microwave heating for 15 min in a citrate buffer (pH 9.0) for antigen retrieval, washed in DW and treated with PBS for 5 min. Non-specific binding was ... See full document

8

Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer

Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer

... AGS cell lines were cultured and main- tained in RPMI - 1640 medium, supplemented with 10 % (v/v) foetal calf serum and 1 % (v/v) penicillin/strepto- mycin (100 000 U/l penicillin, 100 mg/l ...Gastric ... See full document

14

Targeting specificity of dendritic cells on breast cancer stem cells: in vitro and in vivo evaluations

Targeting specificity of dendritic cells on breast cancer stem cells: in vitro and in vivo evaluations

... 4T1 cells were cultured in culture medium supplemented with various levels of verapamil from 0 to 100 µ ...4T1 cells was measured by the xCELLigence Real-Time Cell Analyzer (RTCA) (Hoffmann-La Roche ... See full document

12

Gene expression and pathway analysis of ovarian cancer cells selected for resistance to cisplatin, paclitaxel, or doxorubicin

Gene expression and pathway analysis of ovarian cancer cells selected for resistance to cisplatin, paclitaxel, or doxorubicin

... different drug resistant cell lines (Table ...various cell surface pathways, including ECM-mediated events as altered in cisplatin ...with cell movement were also identified in ... See full document

11

Quantitative phosphoproteomic analysis of acquired cancer drug resistance to pazopanib and dasatinib.

Quantitative phosphoproteomic analysis of acquired cancer drug resistance to pazopanib and dasatinib.

... Drug profiling analysis of in A204 parental and resistant cell lines. 879[r] ... See full document

36

Mechanisms of multidrug resistance in bladder cancer:
the role of the nuclear membrane

Mechanisms of multidrug resistance in bladder cancer: the role of the nuclear membrane

... single cell cultures, ...each cell type per Petri ...MGH-U1-R cells were grown as a single cell culture ...removed, cells were washed with PBS and 1.5mls of 5 x 10 4 cells/ml of ... See full document

327

Transcriptional profiling of NCI/ADR-RES cells unveils a complex network of signaling pathways and molecular mechanisms of drug resistance

Transcriptional profiling of NCI/ADR-RES cells unveils a complex network of signaling pathways and molecular mechanisms of drug resistance

... ovarian cancer cell line relative to ...OVCAR-8 cells revealed 927 differentially expressed genes of 35,377 present in the microarray ...NCI/ADR-RES cells compared to OVCAR-8 (increase ranging ... See full document

17

Paraoxonase 3 is involved in the multi-drug resistance of esophageal cancer

Paraoxonase 3 is involved in the multi-drug resistance of esophageal cancer

... The primary anti-PON3 (17422-1-AP) antibodies and anti- GAPDH (60004-1-lg) antibodies were purchased from Proteintech (San Ying Biotechnology, China) and were recognized with anti-rabbit IgG peroxidase-conjugated ... See full document

11

Dendrosomal curcumin nanoformulation downregulates pluripotency genes via <em>miR-145</em> activation in U87MG glioblastoma cells

Dendrosomal curcumin nanoformulation downregulates pluripotency genes via <em>miR-145</em> activation in U87MG glioblastoma cells

... for cancer therapy because of general lower side ...U87MG cells, a cellular model of glioblastoma, was evaluated by considering master genes of pluripotency and regulatory miRNA (microribonucleic ...U87MG ... See full document

15

NSCLC depend upon YAP expression and nuclear localization after acquiring resistance to EGFR inhibitors

NSCLC depend upon YAP expression and nuclear localization after acquiring resistance to EGFR inhibitors

... with drug resistance in two non-small cell lung cancer (NSCLC) lines (HCC827 and H1975) generated to become resistant to the EGFR tyrosine kinase inhibitors (EGFR TKI) erlotinib, ... See full document

8

Original Article MCT1 promotes the cisplatin-resistance by antagonizing Fas in epithelial ovarian cancer

Original Article MCT1 promotes the cisplatin-resistance by antagonizing Fas in epithelial ovarian cancer

... ovarian cancer were ...the primary antibodies against Fas (1:100, Santa Cruz) and MCT1 (1:100, Santa Cruz) were applied onto the sections which were then incu- bated overnight at ...the primary ... See full document

9

Establishment of lung cancer patient derived xenograft models and primary cell lines for lung cancer study

Establishment of lung cancer patient derived xenograft models and primary cell lines for lung cancer study

... Lung cancer is the leading cause of cancer-related deaths worldwide ...Lung cancer treatments are dominated by chemotherapy, radiotherapy, surgery, even molecular targeted drugs [5, ...lung ... See full document

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