[PDF] Top 20 Mcl1p Is a Polymerase α Replication Accessory Factor Important for S-Phase DNA Damage Survival
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Mcl1p Is a Polymerase α Replication Accessory Factor Important for S-Phase DNA Damage Survival
... to Mcl1p is homologous to the region of mammalian p180 that binds to the simian virus 40 viral replication initiator protein, T antigen, which acts as a dodecameric replicative helicase for viral rep- ... See full document
12
Dna2 Mutants Reveal Interactions with Dna Polymerase α and Ctf4, a Pol α Accessory Factor, and Show That Full Dna2 Helicase Activity Is Not Essential for Growth
... and S phase check- physically and genetically, and the properties of ctf4 points in normal cells to see if these responses were mutants suggest that this binding is biologically relevant ...of S ... See full document
12
Direct removal of RNA polymerase barriers to replication by accessory replicative helicases
... on DNA. For example, the double-stranded DNA translocase activity of ...RNA polymerase (7,8). The formation of RNA-DNA hybrids between the transcript and the template DNA strand ... See full document
27
DNA polymerase α (swi7) and the flap endonuclease fen1 (rad2) act together in the s phase alkylation damage response in S pombe
... for replication pausing and maintenance of the ribonucleotide imprint ...the DNA repair machinery by unknown mechanisms, imprints at other genomic regions could mark sites of DNA damage for ... See full document
14
SMC1-Mediated Intra-S-Phase Arrest Facilitates Bocavirus DNA Replication
... intra-S- phase arrest, endogenous SMC1 was replaced by ectopic expres- sion of a wild-type human SMC1 (hSMC1 wt ) or hSMC1 mutated at serines 957 and ...infection-induced S-phase ...in ... See full document
16
The Genome of Melanoplus sanguinipes Entomopoxvirus
... a photoreactivation repair pathway (cyclobutane pyrimidine dimer photolyase), a LINE-type reverse transcrip- tase, and a mutT homologue. The presence of these specific repair pathways may represent viral adaptation for ... See full document
20
Analysis of the Association of the Human Cytomegalovirus DNA Polymerase Subunit UL44 with the Viral DNA Replication Factor UL84
... (HCMV) DNA synthesis is a virally encoded DNA polymerase that includes a catalytic subunit, UL54, and a homodimeric accessory subunit, UL44, the presumptive HCMV DNA polymerase ... See full document
9
Introduction of Virulence Markers in PB2 of Pandemic Swine-Origin Influenza Virus Does Not Result in Enhanced Virulence or Transmission
... in S-OIVs detected early in the 2009 ...prototype S-OIV A/Netherlands/602/2009, and their effects on virus replication, virulence, and transmission were ...the S-OIV polymerase ...virus ... See full document
7
Direct removal of RNA polymerase barriers to replication by accessory replicative helicases
... of replication products when RNA polymerase is stalled on pPM872 in the absence of ...[ α 32 P] dCTP, the reaction was incubated at 37¡C for 1 minute and a 15 µl sample was removed and ... See full document
13
Cellular Topoisomerase I Modulates Origin Binding by Bovine Papillomavirus Type 1 E1
... origin DNA resulted in an E1-DNA complex ...origin DNA. At higher levels of Topo I, a Topo I-DNA complex that migrated slightly faster than the E1-DNA complex was seen ...origin ... See full document
9
Effects of Substitutions of Arginine Residues on the Basic Surface of Herpes Simplex Virus UL42 Support a Role for DNA Binding in Processive DNA Synthesis
... Full DNA binding by UL42 may depend on all of these residues, although not all of these residues may be in contact with DNA at any one ...on DNA may require that negatively charged phosphates be ... See full document
10
Interactions of the Papovavirus DNA Replication Initiator Proteins, Bovine Papillomavirus Type 1 E1 and Simian Virus 40 Large T Antigen, with Human Replication Protein A
... in DNA replication (7, ...SV40 DNA replication in vitro ...SV40 DNA replication in ...the DNA replication functions of RPA14 and RPA32 may be merely to stabilize ... See full document
9
Dissecting the Fidelity of Bacteriophage RB69 DNA Polymerase: Site-Specific Modulation of Fidelity by Polymerase Accessory Proteins
... gp43 accessory proteins exerted little or no effect on total mutation rates in vitro, they strongly affected mutation rates at many specific sites, increasing some rates and decreasing ... See full document
16
Human cytomegalovirus. IV. Specific inhibition of virus-induced DNA polymerase activity and viral DNA replication by phosphonoacetic acid.
... Specific Inhibition of Virus-Induced DNA Polymerase Activity and Viral DNA Replication by Phosphonoacetic Acid Phosphonoacetic acid specifically inhibited human cytomegalovirus DNA synth[r] ... See full document
6
Tof1p Regulates DNA Damage Responses During S Phase in Saccharomyces cerevisiae
... the S phase branch of the MEC1-dependent DNA damage response ...slowing S phase in response to MMS, inducing RNR3 transcription in response to UV, and phosphorylating Rad53p in ... See full document
11
<p>CDKN3 promotes tumor progression and confers cisplatin resistance via RAD51 in esophageal cancer</p>
... are important factors that in fl uence patient ...5-year survival is about 20%, the standard treatment consists of chemotherapy or chemoradiotherapy with ... See full document
12
Genetic Confirmation that the H5 Protein Is Required for Vaccinia Virus DNA Replication
... double-stranded DNA (dsDNA) ge- nome (⬃195 kb) which is replicated in the cytoplasm of the host cell, exhibiting both physical and genetic autonomy from the cell ...for DNA repli- cation in cultured cells. ... See full document
16
Mi Young Son 1, Chu-Xia Deng2 , Jan H. Hoeijmarkers 3, Vivienne I. Rebel 4,5,6,7,8 Paul Hasty 1,5,6
... inhibit replication fork restart and increase supercoiling upstream of the ...and DNA-PK CS responses to phosphorylate RPA ...repair DNA DSBs and maintain stabile replication ... See full document
15
Regulation and Modulation of Human DNA Polymerase δ Activity and Function
... Discontinuous DNA synthesis at the lagging strand in eukaryotes involves the synthesis of Okazaki fragments of ...allowing DNA ligase action ...by DNA ligase I ... See full document
30
Inhibition of the Herpes Simplex Virus Type 1 DNA Polymerase Induces Hyperphosphorylation of Replication Protein A and Its Accumulation at S-Phase-Specific Sites of DNA Damage during Infection
... the S phase of the cell cycle (11, 30–32, 46; our unpublished results), we propose that these cells were undergoing an S-phase-specific DNA damage response to rep- lication ... See full document
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