The change in arterial bloodpressure and pulse- rate is one of the generally known physiological changes in aging of man. Many factors are responsible for the rise of bloodpressure of which age is one of the factors. Pooling of blood in lower extremities occur due to gravitational effects. It reduces venous return and stroke volume with a fall in systolic bloodpressure.
6. Elissa Wilker, Murray A. Mittleman, Augusto A. Litonjua, Audrey Poon, Andrea Baccarelli, Helen Suh, Robert O, Wright, David Sparrow, Pantel Vokonas, and Joel Schwartz. PosturalChanges in BloodPressure Associated with Interactions between Candidate Genes for Chronic Respiratory Diseases and Exposure to Particulate Matter. Envir Healt Persp. 2009; 117: 935-940
Green tea has become the subject of interest because of its beneficial effects on human health. Green tea (GT) contains catechins which reduces radicals and thereby protects from cardiovascular diseases. Diabetes mellitus and cardiovascular problems are most severe problems which are encountered most frequently in our country. Aim of the study was to study Bloodpressure, Cholesterol and Triglycerides levels changes in short term green tea Consumption persons in south Indian population. The Present study was carried out in the Department of Biochemistry, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry. The analysis of plasma LDL, Cholesterol, triglycerides were evaluated by enzymatic methods, Bloodpressure were calculated by using BP operator. The results indicated that green tea beverages and green tea extract supplementation significantly reduced TC and LDL-cholesterol concentrations and bloodpressure. Green tea intake results in significant reductions in bloodpressure, total cholesterol, and LDL cholesterol. The effect size on systolic bloodpressure is small, but the effects on total and LDL cholesterol appear moderate. Longer-term independent clinical trials evaluating the effects of green tea are warranted.
Non-Caucasian ethnicity predicted a higher BCD (regression coefficient (RC)= -11.32, 95% CI [-17.75, -4.89], p < 0.001) and MCD (RC = -12.20, 95% CI [-19.35, -5.05], p < 0.001) at birth and a more significant percentage reduction in BCD between birth and 3 months (RC = -11.55, 95% CI [-22.85, - 0.25], p = 0.0452). A lower gestational age predicted a significantly higher BCD at birth (RC = -2.98, 95% CI [-4.07, -1.88], p < 0.0001), 3 months (RC = -1.93, 95% CI [-3.33, -0.52], p = 0.0078), and 6 months (RC = -1.41, 95% CI [-2.55, -0.28], p = 0.0155) but only predicted a higher MCD at birth (RC = - 2.24, 95% CI [-3.46, -1.03], p < 0.001) and 6 months (RC = -2.14, 95% CI [-3.55, -0.73], p < 0.005). All other maternal parameters or predefined measures of infants’ growth (including maternal BMI at booking, antenatal history of gestational diabetes mellitus, family history of hypertension, gestational age of the infant at birth (weeks), maternal age at time of baby’s birth, and smoking history before pregnancy) were not found to be statistically significant predictors of CD changes. BP results:
preceding period of asphyxia. Given the distensibil- ity of the neonatal skull, variations in vascular trans- mural pressure may occur with the changes in blood volume; this effect will be larger with smaller in- creases in intracranial pressure in the case of highly compliant skulls. Obstruction of venous return by an unfavorable head position thus may expose the infant to increased venous volume and pressure, and increase the risk of intracranial bleeding. Al- though we have not found a correlation between posturalchanges in ⌬ CBV and birth weight, the (⌬CBVlat⫺CBV) changes seemed to be higher in the smallest patients (Fig 4). This may be attributed to their more compliant neck structures, but they also would have more compliant skulls. Changes in ve- nous transmural pressure may be broader in range and the risk of intracranial bleeding could be greater. In our study, there were no simultaneous varia- tions in SaO 2 31 or Pco 2 , 17,32 that could have affected
BACKGROUND: Early detection of proneness to hypertension may help an individual to lead a healthy life by altering the lifestyle. Individuals having the predisposing factors of hypertension tend to show higher and prolonged responsiveness to bloodpressure following stress. With this hypothesis, in present study an attempt has been made to explore the cardiovascular reactivity to stress (cold stress) and the recovery time after the withdrawal of the stressor in normotensive young adults. MATERIAL AND METHODS: The study group comprised of asymptomatic normotensive participants (18-25 years) of either sex (n=50). These individuals were selected based on a positive family history of hypertension (either or both parents). The control group was comprised of similar group of individuals (n=50) but with no history of hypertension in the family. The cold pressor test was carried out. The changes in bloodpressure among the participants of the hypertensive and normotensive families were compared using Student‟s t-test. RESULTS: The present study has shown that the increase in the response of the bloodpressure profile is more in participants with positive family history of hypertension compared to participants with negative family history of hypertension. Recovery to the baseline after cold pressor test also was slow amongst the positive family history groups compared to participants with negative family history of hypertension. CONCLUSION: The present study suggests that a state of hyper-responsiveness may precede essential hypertension and that the cold pressor test could be useful as a predictor of future hypertension in a young study population. The cold pressor tests may thus identify a subgroup of individuals with an occult physiological abnormality that predisposes them to hypertension decades later.
Abstract: Non-functional adrenal adenomas (NFAs) are associated with increased incidence of hypertension. The aim of this follow-up study was to assess the efficacy of adrenalectomy in the treatment of NFA patients with hyper- tension, and determine whether the surgical outcomes were associated with endocrinological changes. Between March 2002 and March 2013, 126 consecutive patients with NFA underwent adrenalectomy in our hospital. Of these, 90 (71.4%) individuals had preoperative hypertension, while 36 were normotensive. The patients with hyper- tension were reevaluated for bloodpressure after a mean follow-up time of 59.2 (6-144) months. There were no statistically significant differences in clinical and endocrinological parameters between the hypertensive and nor- motensive groups. A total of 57/90 (63.3%) hypertensive patients showed hypertension control improvement after operation. However, there were no significant changes in endocrinological properties before and after operation, in both patient groups with improved and unimproved hypertension control. Multivariable analysis showed that age, pre-surgery hypertension grade, pre-surgery hypertension duration were significantly associated with an increased risk of non-effect after surgery in NFA patients (P<0.05). After adjusting age and pre-surgery antihypertensive medi- cation, the RR value of pre-surgery hypertension grade was 2.525 (95% CI: 1.208-5.278), and the RR value of pre-surgery hypertension duration was 3.406 (95% CI: 1.257-9.226). These data suggested that adrenalectomy could be considered in NFA patients with hypertension, especially those with low hypertension grade and/or short hypertension course. Further studies are needed to clarify the underlying mechanisms.
In normotensive endurance trained men, high intensity interval exercise resulted in a similar magnitude of decrease in bloodpressure to steady-state aerobic exercise (cycling) , although differential changes in stroke volume and total peripheral resistance were observed in the two exercise modes. Only a few studies used intermittent exercise in hypertensive individuals, since continuous aerobic exercise has been traditionally, recommended . However, recent data showed that intermittent exercise (1min at 80% of heart rate reserve with 2min at 50%) exerted beneficial effects in medicated hypertensive patients, increasing the percentage of time with normal ambulatory bloodpressure values over 24 hours after the exercise session . A study by Lacombe et al.  also showed that older prehypertensive adults experienced similar PEH following equicaloric bouts of intermittent (5×2:2min at 85% and 40% of VO2 peak) and steady state (21min at 60% maximal oxygen uptake) exercise, despite differences in the regulation of bloodpressure during exercise between the two exercise modes (i.e. larger alterations in heart rate variability and baroreceptor sensitivity elicited by the intermittent exercise) Future studies should, however, examine the effects of isoeffort or isostrain exercise when comparing the effects of intermittent and steady state exercise, to isolate the effects of the exercise mode (continuous vs. intermittent) from those of the effects of exercise intensity.
All patients in the designated lists were interviewed on the day before operation. A standard proforma data collection sheet (Appendix) was used to collect the demographic data, medical history, pharmacological therapy, systolic bloodpressure (SBP), diastolic bloodpressure (DBP) and pulse rate (PR) readings. The pre-operative bloodpressure was defined as the mean of the last 5 awake BP readings taken on the day before surgery. All the BP and pulse rate readings in the operation theatre (OT) were taken by the same researcher (KSP), using a standard non-invasive bloodpressure monitoring device. The first BP reading taken when the patient entered the operation room was recorded as the BP ‘On Arrival’.
compared to diastolic blood in standing position as well as sitting position. After doing statistical analysis, it was found that there is significant correlation in between bloodpressure varies in lying position than in standing position in hypertensive patients (p < 0.01) with less error in bloodpressure recording (p < 0.05).
In this study we show that aqueous extract of R. chalepensis and its methanol fraction, when tested on bloodpressure of normotensive rats and L-NAME-treated rats induced a dose-dependent reduction the bloodpressure, which is in line with its traditional use in hypertension (5). The hypotensive effect of the RCAE was brief in normotensive rats. We have observed in our earlier studies that the duration of action of the plant extracts or pure chemicals even with other action mechanism such as Ca +2 channel blockade, is usually brief when tested in normotensive animals (16, 17) mainly because of intact physiological compensatory mechanisms in these animals. RCMF showed a greater hypotensive effect that RCAE, suggesting the enrichment of the active compounds. The observation that RCAE reduced the hypertension produced by the acute administration of phenylephrine suggest that the hypotensive effect of RCAE could, partially at least, be mediated through α-adrenergic mechanisms.
positive subjects between December 2015 and August 2016. Patients attending Hematology Clinic of Enugu State University Teaching Hospital Parklane, Enugu, were enrolled for the study. Ninety subjects were included into the study consisting of sixty HIV positive patients and thirty apparently healthy HIV negative individuals. HIV positive patients were further grouped into those that are antiretroviral naïve and those on drugs. Peripheral blood samples were collected by venepunture from all participants into sodium citrate; for the determination of prothrombin time and activated partial thromboplastin time, ethylene diamine tetra- acetic acid(EDTA); for the measurement of platelet and CD4+ count and plane tube; serum was expressed for the measurement of endothelial specific molecule -1(endocan). The study was performed according to the guidelines as stipulated by the Helsinki declaration.
Three separate bloodpressure (BP) readings were taken per subject, at two minutes intervals, after an initial 10 minutes rest, in a seated position, using an automated digital monitor (Omron HEM-741 CINT), and appropriate cuff sizes. The device has an error of measurement of ± 3 mmHg, according to the manufac- turers. The average of the last two readings was recorded for both systolic and diastolic blood pressures of each student. Each subject was thereafter asked if he/ she ever had a BP measurement in the past, and the response recorded. The same trained personnel took all bloodpressure measurements.
Both systolic and diastolic bloodpressure of normal guinea pigs was reduced (p=0.05, p=0.001) in when guinea pigs were intravenously treated with ethanol extract of P. guava leaf (Figures 1 and 2). The reduction of bloodpressure in normotensive guinea pigs was might be due to different phytochemical compounds. Similarly study done by [8, 32] phytochemicals such as lycopene and quercetin have potential to induce vasodilation by stimulating production of nitric oxide that can cause relaxation of smooth blood vessels. Another study also described that on aqueous leaf extract of Anona muricata showed that there was decreased bloodpressure in normotensive Sprague Dawley rats . This is might be by the mechanisms of antagonism of Ca 2+ which results vasodilation of blood vessels. Similarly researches done [14, 18] on fruits of lemongrass and chayote showed antihypertensive effect.
Background: Orthostatic hypotension (OH), a bloodpressure drop after postural change, is associated with impaired standing balance and falls in older adults. This study aimed to assess the association between bloodpressure (BP) and a measure of quality of standing balance, i.e. Center of Pressure (CoP) movement, after postural change from supine to standing position in geriatric outpatients, and to compare CoP movement between patients with and without OH. Methods: In a random subgroup of 75 consecutive patients who were referred to a geriatric outpatient clinic, intermittent BP measurements were obtained simultaneously with CoP measurements in mediolateral and anterior-posterior direction directly after postural change during 3 min of quiet stance with eyes open on a force plate. Additional measurements of continuous BP were available in n = 38 patients. Associations between BP change during postural change and CoP movement were analyzed using Spearman correlation. Mann- Whitney-U tests were used to compare CoP movement between patients with OH and without OH, in which OH was defined as a BP drop exceeding 20 mmHg of systolic BP (SBP) and/or 10 mmHg of diastolic BP (DBP) within 3 min after postural change.
protentiation by this peptide. A similar pattern of bloodpressure decrement and potentiation was seen in genetically hypertensive rats when propranolol or saralasin treatment preceded hydralazine. Propranolol was demonstrated to block hydralazine-induced increases in serum renin activity in genetically hypertensive rats. We conclude that hypotensive potentiation of vasocilating drugs by propranolol in these animal models is mediated to a large extent by impairment of renin release. Persistence of hypotensive tachycardia after nephrectomy and after […]
CVD is the number one global cause of death. In 2008, CVD accounted for 17.3 million deaths and this number is projected to increase to 23.3 million deaths in the year 2030 (WHO, 2013). Fortunately, due to advancements in treatment many individuals who may have died from CVD are able to live with the disease. Consequently, the persistence of individuals with CVD poses strains on the economy. In Canada, coronary heart disease, stroke, and heart disease due to high bloodpressure incur $21 billion in expenses to provide medication, hospitalization and disability compensation (Theriault et al., 2010). Individuals living with CVD often miss work due to hospitalization and experience lower productivity than non-afflicted individuals (Theriault et al., 2010). In addition, patients living with CVD experience a significant reduction in their quality of life due to the strain of coping with illness (Juenger et al., 2002). Accordingly, the World Health Organization (WHO) has deemed CVD a global health crisis with emphasis on primary prevention as the key to slowing its deadly progression (WHO, 2013).
The correlations of baseline clinical variables with changes in HbA1c after onset of dapagliflozin treatment were investigated using linear regression. Only baseline HbA1c was statistically significantly inversely related to change in HbA1c after both 3 and 6 months, indicating that higher HbA1c values were related to a greater decrease after onset of dapagliflozin treatment (P< 0.0001). Furthermore, age was positively correlated with the HbA1c decrease observed at 3 months, indicating that HbA1c increased with age after the index date (Table 4). Finally, diabetologist treatment Table 1 Baseline characteristics of type 2 diabetes patients who