[PDF] Top 20 B-cell precursor acute lymphoblastic leukemia and stromal cells communicate through Galectin-3

... ALL cells with extracellular Galectin-3 modulates ...higher Galectin-3 protein levels than OP9 cells alone, we considered the possibility that Galectin-3 may be ... See full document

... mouse B-cell development, high expression levels of Galectin-1 (also known as L14 lectin) mRNA in the pre-B cell stage decrease notably as the cells further mature, and thus high ... See full document

... a cell‑mediated hypersensitivity mechanism in bronchial asthma ...lineage cells have been recurrently reported in association with clonal hematopoietic disorders [40, ... See full document

... with B cell precursor acute lymphoblastic leukemia ...progenitor cells. Notably, the mean PE of leukemic B cell precursors from patients with a pseudodiploid ... See full document

... Pathology confirmed the presence of multiple BCCs and in addition the three biopsy sites showed diffuse infiltra- tion of the dermis by large, atypical cells with blastic mor- phology and displaying perineural and ... See full document

... (DS-associated) B-ALL cases (71, 72) and are also present in up to 50% of a novel subtype of high-risk B-ALL, BCR-ABL1–like ALL (see below) ...in B-ALL. The JAK mutations in B-ALL most ... See full document

... (R/R) acute lymphoblastic leukemia (ALL) have a dismal prognosis of around 5% long-term survival when treated with cytotoxic chemotherapy and allogenic stem cell ...CD19-positive ... See full document

... In order to investigate the concordance in CIMP status between diagnosis and relapse samples we compared CIMP status in 23 paired samples from patients with available DNA at both time points. This analysis showed an ... See full document

... human leukemia cells would be mediated via its CD19L domain, the use of the fusion protein was also anticipated to result in a much higher and more stable accumulation of the sTRAIL domains on the surface ... See full document

... between cell lines and cytostatic ...BCP-ALL cells in regard to sequence of drug exposure including ...ALL cells differently [36, ...when cells were exposed sequentially with DEC followed by ... See full document

... blood cells (WBC) at 123×10 9 /l, consisting of 12% neutrophils, 75% lymphocytes, 11% monocytes and 1% ...blood cell (RBC) count was 3.26×10 6 /mm 3 , hemoglobin level ... See full document

... With regard to other CNAs and in concordance with previous findings in PAX5-rearranged leukemias, few dele- tions and/or gains are observed [3, 4]. Here, we detected a heterozygous deletions affecting ... See full document

... resistance at the level of B-lineage LPC. The highest CD34 expression group (> or = 75% positivity) had 1.4-fold higher SF2 (P = 0.05) and twofold lower alpha values (P = 0.06) than the lowest group (< 30% ... See full document

... pediatric B cell acute lymphoblastic leukemia, representing 25% of the ...human leukemia cell lines AT-2 and REH, which express ETV6-RUNX1, suggested that SPIB was one of ... See full document

... Case 1 was an otherwise healthy 5-year-old boy with left-sided exophthalmos, a swollen lacrimal gland and a bluish-red discolouration of the eyelid. The eye examination, including visual acuity, was normal. A CT scan ... See full document

... advances, leukemia relapse remains the main prob- lem that reduces the cure rates after alloHSCT ...patient-derived cells survived the myeloablative therapy and the original leukemic cell reappears ... See full document

... share cell antigens which characterize T- and myeloid phenotypes, we wanted to test if molecular aberrations frequently found in T-ALL and AML would help in the distinction of ETP-ALL from T/ M-MPAL in our ... See full document

... (ES) cells using Hi-C data. Acknowl- edging limitations that these cell types may not fully reflect ALL biology, the regions containing rs28665337 and rs17481869 show significant chromatin looping ... See full document

... was no definitive involvement in other craniofacial bones. A panoramic radiograph taken 4 months before had indicated no bony involvement. In this case a CBC count showed a slightly decreased red blood cell count, ... See full document

... contains B cell follicles and paracortical T-0cell zones and the medulla contains medullary cords and ...venules through which T and B cells and the antigen presenting cells ... See full document