[PDF] Top 20 Prediction of genetic contributions to complex traits using whole genome sequencing data
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Prediction of genetic contributions to complex traits using whole genome sequencing data
... additive genetic variance ( σ g 2 ), repeated environmental variance ( σ c 2 ), and error var- iance ( σ e 2 ), of model (1) were ...0.18 using formula (2), which means that 18% of phenotypic variance was a ... See full document
6
A goodness of fit association test for whole genome sequencing data
... many genetic factors have been successfully identified for human diseases in genome-wide association studies, genes discovered to date only account for a small proportion of overall genetic ... See full document
6
Host Genome Influence on Gut Microbial Composition and Microbial Prediction of Complex Traits in Pigs
... and complex traits in pigs using extended quantitative-genetic ...SNP data and the microbiota composition were used to predict the complex traits using genomic best ... See full document
8
Higher criticism approach to detect rare variants using whole genome sequencing data
... Whole genome sequencing (WGS) is able to reveal complete genetic variations across the entire ...of genetic pathology to complex traits ...detecting genetic factors ... See full document
6
An epidemiological perspective on the future of direct-to-consumer personal genome testing
... Personal genome testing is offered via the internet directly to ...use data from genome-wide scans to predict risks for multiple common diseases and ...for genetic risk groups. In the near ... See full document
5
Genome sequencing of the extinct Eurasian wild aurochs, Bos primigenius, illuminates the phylogeography and evolution of cattle
... with data from autosomal poly- ...aurochs genome with genome information from modern animals highlights the complex domestic history of cattle, most notably a Northern Eurasian aurochs com- ... See full document
15
Genome sequencing and crop improvement
... unassembled genome sequence data and expressed sequence tags (EST). This data can also be applied for SNP and simple sequence repeats (SSR) molecular marker discovery, though without a reference ... See full document
5
Genetic Control of Environmental Variation of Two Quantitative Traits of Drosophila melanogaster Revealed by Whole-Genome Sequencing
... weak genetic marker-based relationships among ...additive genetic variance or to narrow sense ...populations, using genomic best lin- ear unbiased ...obtained using pedigree-based or ... See full document
21
Population Genetic Methods for Detecting Genetic Contributions to Complex Traits.
... to genome-wide scans rather than candidate gene ...recent whole-genome sequencing of a single quartet, with both offspring affected with Miller’s syndrome and primary ciliary dyskinesia, ... See full document
208
A dual clustering framework for association screening with whole genome sequencing data and longitudinal traits
... Current sequencing technology enables generation of whole genome sequencing data sets that contain a high density of rare variants, each of which is carried by, at most, 5% of the ... See full document
5
A multi level model for analyzing whole genome sequencing family data with longitudinal traits
... Longitudinal genetic studies enable a close investigation of both genetic factors that lead to a disease and envir- onmental determinants that modulate the subsequent progression of the ...family ... See full document
5
An exploration of heterogeneity in genetic analysis of complex pedigrees: linkage and association using whole genome sequencing data in the MAP4 region
... Whole genome sequencing holds out the promise of being able to more effectively map the effects of genetic variants on complex traits, and thereby identify the causal variants ... See full document
6
Genetic Analysis and Prediction of Complex Traits in Drosophila melanogaster.
... error) prediction accuracy than the other two traits with any of the models ...more complex genetic architecture of this trait, with a large number of epistatic interactions (Huang et ...that ... See full document
149
Application of resequencing to rice genomics, functional genomics and evolutionary analysis
... constructed using a novel data-imputation ...cultivars using 1,917 SNPs to clarify the dynamics of the pedigree haplotypes (Yamamoto et ...on genome-wide SNP ana- lysis, these studies revealed ... See full document
10
On the SNP-based and Sequence-based Whole Genome Studies for Complex Traits.
... upweights the contribution from rare variants. As expected, the relative performance between rare-variant and all-variant approaches depends on the underlying causal allele frequencies. When causal allele frequencies are ... See full document
158
Molecular epidemiology, cluster analysis, and drug resistance prediction of Mycobacterium tuberculosis complex in Ireland using conventional methods and Whole Genome Sequencing
... 52 possibly broken. More clusters appear to be present, but for the most part, their numbers are low. Eighteen clusters were found within Euro-American lineage 4 in the original IMRL paper, involving 63 TB cases; 114 ... See full document
322
Genome sequence of Coxiella burnetii strain Namibia
... BGM cells (Flow Laboratories, Rockville, MD, USA) were grown in Eagles minimal essential medium (MEM) supple- mented with Earls salts, 2 mM L-glutamax, 5% Fetal Calf Serum (FCS), 1% Non-Essential Amino acids (NEA) and ... See full document
9
<p>From Clinical Phenotype to Genotypic Modelling: Incidence and Prevalence of Recessive Dystrophic Epidermolysis Bullosa (RDEB)</p>
... a training set. The pathogenicity of splice site mutations is also dif fi cult to predict, making them particularly susceptible to misclassi fi cation; even though a conservative threshold was used, some benign variants ... See full document
10
A protocol for the identification and validation of novel genetic causes of kidney disease
... parallel sequencing (MPS) from ap- proximately 2005 [14] has arguably been the next greatest advance since the development of Sanger sequencing in the late 1970s [15, ...generation sequencing (NGS) ... See full document
10
Genetic mapping and evolutionary analyses of the black grain trait in barley
... In addition to the exceptional health benefit, black barley also has important biological significance. Earlier study has indicated black barley is significantly less affected by Fusarium disease (Choo et al., 2015), ... See full document
11
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