[PDF] Top 20 Predictive Modeling for Developmental Toxicity of Engineered Nanomaterials.
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Predictive Modeling for Developmental Toxicity of Engineered Nanomaterials.
... of toxicity prediction, where the primary theory is that similarly characterized materials will behave in a similar manner in regards to toxic ...described predictive models utilize data from various ... See full document
122
Structure-activity relationship models for hazard assessment and risk management of engineered nanomaterials
... of engineered nanomaterials (ENMs) for commercial purposes made human exposure to these materials almost ...(Q)SAR modeling of potential hazards of ENMs and demonstrating the use of (Q)SAR to predict ... See full document
11
Identifying the Potential Environmental Impacts of Engineered Nanomaterials
... of nanomaterials better and advance these methods the following research questions are ...of nanomaterials that drive ...of nanomaterials themselves and have therefore underestimate the total ...with ... See full document
120
In vitro detection of in vitro secondary mechanisms of genotoxicity induced by engineered nanomaterials
... of engineered nanomaterials (NMs) is vital to ensure the health and safety of those exposed to ...limited predictive power of current in vitro models and the unsustainability of conducting ... See full document
14
Cellular Toxicity and Immunological Effects of Carbon-based Nanomaterials
... Carbon nanomaterials reportedly exhibit harmful ef- fects on macrophages. Macrophages play a key role in the ingestion of microorganisms and tissue homeostasis. One study revealed that the function of human ... See full document
27
Innate Immune Responses to Engineered Nanomaterials During Allergic Airway Inflammation
... (PAMP) binding to a pattern recognition receptor (PRR), and 2) phagocytosis of a foreign agent that disrupts the lysosomal membrane and releases cathepsin B to trigger assembly of the inflammasome components (NLRP3, ASC, ... See full document
185
Safer-by-design flame-sprayed silicon dioxide nanoparticles: the role of silanol content on ROS generation, surface activity and cytotoxicity
... Although this ENM is classified as Generally Regarded as Safe (GRAS) by the Food and Drug Administration (FDA), and used extensively in consumer products, in- cluding as a food additive in numerous food products [12], ... See full document
15
Usefulness of myeloperoxidase as a biomarker for the ranking of pulmonary toxicity of nanomaterials
... pulmonary toxicity of nanoparticles, using inhaled che- micals including nanomaterials which were classified as having pulmonary ...pulmonary toxicity in both intratracheal instillation and ... See full document
14
CAESAR models for developmental toxicity
... For the AFP model Hybrid Selection Algorithm (HSA) was used to select the best parameters out of the 790 molecular descriptors for classifying the chemicals by their toxicity potency. This method combines the ... See full document
11
Artificially controlled degradable nanoparticles for contrast switch MRI and programmed cancer therapy
... low toxicity, it can be claimed that the artificially controlled degradable nanomaterials can be a promising candidate for controllable drug release and also provide a novel strategy for designation of the ... See full document
13
Comparing Predictive Values of Two diagnostic tests
... the predictive values of the diagnostic test is likely to be biased which is called verification bias ...the predictive value from the observed data may not be biased by the definition ... See full document
75
The predictive value of cumulative toxicity for quality of life in patients with metastatic colorectal cancer during first-line palliative chemotherapy
... When interpreting the results of this study, it is impor- tant to consider the following points. First, we tested our hypotheses with a primary focus on treatment-related AEs, even though these are sometimes hard to ... See full document
7
Ingested engineered nanomaterials: state of science in nanotoxicity testing and future research needs
... different nanomaterials in multi-nanomaterial in vitro studies [61, 64, ...iENM toxicity studies, we recommend using a mathematical approach for calculation of nominal doses based on published esti- mated ... See full document
31
Application of dental nanomaterials: potential toxicity to the central nervous system
... dental nanomaterials have created more exposure opportunities to these NPs in both dental staff and ...of nanomaterials, it is essen- tial to determine the neurotoxic effects of ... See full document
19
Particle length-dependent titanium dioxide nanomaterials toxicity and bioactivity
... Similarly, AM were loaded with dihydoethidium (DHE) to measure intracellular ROS directly and the results are presented in the Figure 5e. All of the TiO2 nanoparticles caused statistically significant increases in ... See full document
11
Potential toxicity and safety evaluation of nanomaterials for the respiratory system and lung cancer
... Toxic effects of ENPs may be attributed to two different actions: chemical toxicity based on the chemical com- position (eg, release of toxic ions), and particle surface catalyzed reactions that generate damaging ... See full document
12
Multidisciplinary Approaches and Insights into the Ecotoxicology of Engineered Nanomaterials by the UC CEIN
... Foundation Institute for Materials Science, University Bremen, Germany; University College Dublin; Nanyang Technological University; Cardiff University Wales, University of British Col[r] ... See full document
26
An integrated approach for the in vitro dosimetry of engineered nanomaterials
... flame-generated nanomaterials to translocate across alveolar epithelial monolayers in vitro ...the toxicity of low aspect ratio ENMs reported ratios of slopes for delivered dose vs administered dose varying ... See full document
12
The current state of engineered nanomaterials in consumer goods and waste streams: the need to develop nanoproperty-quantifiable sensors for monitoring engineered nanomaterials
... Exposure to high levels of nanosilver can be toxic and the toxicity profile is different from that of ionic silver. Our level of concern should be based on current and projected environmental concentrations and ... See full document
14
Engineered nanomaterials: exposures, hazards, and risk prevention
... most predictive dose metric; the rate and nature of interacting proteins and effect of opsonization on uptake, translocation and effects; the influence of size, shape, charge, and surface reactivity on the extent ... See full document
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