[PDF] Top 20 Predictive value of C-reactive protein in patients treated with sunitinib for metastatic clear cell renal cell carcinoma

... 77 patients with mRCC was screened for in- clusion in this prospective study at Haukeland University Hospital, Bergen, ...Forty-six patients were enrolled after signing the informed consent sheet (CONSORT ... See full document

... of sunitinib, pazopanib, or bevacizumab plus interferon as first-line treatment for favorable- or intermediate-risk patients with metastatic, clear cell RCC ...files, sunitinib ... See full document

... ccRCC patients treated with PD-1 or PD-L1 inhibitor alone or combined with anti-CTLA-4 therapies was correlated with the loss of PBRM1, which may alter responsiveness upon immune checkpoint therapy ... See full document

... non-clear cell RCC and have found evidence suggestive that VEGF TKIs have therapeutic value in the treatment of ...particular, sunitinib and the mTOR inhibitor everolimus, have been ... See full document

... of patients are currently diagnosed: i) M0 patients that have good prognosis although some patients progress toward a M1 phase without any robust method to predict such a pejorative evolution, and ... See full document

... cut-off value of ...CCRCC patients with only small lung metastatic lesions ...CCRCC patients, especially in Japan, because of their low toxicity and ability to achieve long-term stable disease ... See full document

... prognostic value in clear cell renal cancer (ccRCC) have not been ...176 patients who had undergone surgery in hospital for histologically proven ...Prognostic value and ... See full document

... 40 patients treated with sorafenib was ...26 patients treated with sunitinib was not ...the sunitinib group was higher than the sorafenib ...(57.6%) patients classified ... See full document

... of sunitinib in the Japanese population ...line-treated patients were ...treatment-naïve patients and those receiving first-line treatment with molecular-targeted therapy were included; ... See full document

... in renal cell carcinoma [24, ...for patients with metastatic renal cell carcinoma ...predictive value. Numbers of arti- cles had indicated the ... See full document

... with metastatic RCC after nephrectomy and IL-2-based ...in patients with metastatic RCC treated with different subcutaneous recombinant cytokine-based home therapies in consecutive ... See full document

... Twenty-nine patients with long-term clinical benefit from sunitinib were identified between September 2005 and August ...Nine patients (the total number of patients treated with ... See full document

... Akt protein phosphorylation, result in tumor cells arrest in G1 phase and induce apoptosis ...NSCLC patients with EGFR mutation and who received EGFR-TKIs ...NSCLC patients who received EGFR-TKIs as ... See full document

... associated with poor OS and DFS (Figure 1A, 1B). In univariate Cox proportion hazard ratio analysis, age, T stage, positive lymph nodes, metastasis, tumor stage and high COL6A1 expression were significantly associated ... See full document

... fi c guidelines for the treatment of immune-related myocarditis and the recommended approach consists of immunosuppression and classical heart failure man- ...when patients have not achieved a successful ... See full document

... addition, patients with RCC of sarcoma- toid differentiation historically have had a worse prognosis, with poor response to VEGF therapy ...these patients have promising options with immune-based ... See full document

... during cell cycle and its protein expression support that Plk5 is a tumor ...a cell cycle. The mRNA perturbation of Plks (Plk1-5) during a cell cycle is plotted along a cell ...Plk5 ... See full document

... for metastatic disease was cytokine-based treatment with high dose interleukin-2 (IL-2) and interferon-alpha (IFN-α) after their FDA approval in the 1990s ...of patients, and outcome for the majority of ... See full document

... of sunitinib on mutation and methylation of these driver genes to provide evidence for predictive biomarkers and mechanisms of ...after sunitinib therapy, from mccRCC patients within a ... See full document

... In order to evaluate the potential of DNA methylation as a more stable readout in the process of response and acquisition of resistance to targeted therapy, the change in methylation status of the 48 ccRCC related genes ... See full document